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    Hmgxb3 HMG box domain containing 3 [ Mus musculus (house mouse) ]

    Gene ID: 106894, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Hmgxb3provided by MGI
    Official Full Name
    HMG box domain containing 3provided by MGI
    Primary source
    MGI:MGI:2441817
    See related
    Ensembl:ENSMUSG00000024622 AllianceGenome:MGI:2441817
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA0194; 2510002C16Rik; A630042L21Rik
    Summary
    Is expressed in central nervous system; early conceptus; female reproductive system; and urinary system. Orthologous to human HMGXB3 (HMG-box containing 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in ovary adult (RPKM 11.8), adrenal adult (RPKM 11.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Hmgxb3 in Genome Data Viewer
    Location:
    18 E1; 18 34.41 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (61264349..61310122, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (61131277..61177050, complement)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene platelet derived growth factor receptor, beta polypeptide Neighboring gene Csf1r promoter/intronic regulatory region Neighboring gene colony stimulating factor 1 receptor Neighboring gene microRNA 6983 Neighboring gene predicted gene, 26403 Neighboring gene predicted gene, 50614 Neighboring gene STARR-positive B cell enhancer ABC_E7591 Neighboring gene solute carrier family 26 (sulfate transporter), member 2 Neighboring gene STARR-seq mESC enhancer starr_44740 Neighboring gene predicted gene, 52353 Neighboring gene phosphodiesterase 6A, cGMP-specific, rod, alpha Neighboring gene ribosomal protein S2, pseudogene 10

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The ROQ domain of Roquin recognizes mRNA constitutive-decay element and double-stranded RNA. Tan D, et al. Nat Struct Mol Biol, 2014 Aug. PMID 25026078, Free PMC Article
    2. Accelerating functional gene discovery in osteoarthritis. Butterfield NC, et al. Nat Commun, 2021 Jan 20. PMID 33473114, Free PMC Article
    3. Placentation defects are highly prevalent in embryonic lethal mouse mutants. Perez-Garcia V, et al. Nature, 2018 Mar 22. PMID 29539633, Free PMC Article
    4. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295
    5. A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract. Wiese CB, et al. Front Neurosci, 2012. PMID 22988430, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    HMG domain-containing protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_134134.2 → NP_598895.2  HMG domain-containing protein 3 isoform 2

      See identical proteins and their annotated locations for NP_598895.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame segment in the 5' coding region, compared to variant 1, resulting in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AB045322, AK041866, AK132529, BC025148, BG061435, BU611563
      Consensus CDS
      CCDS50301.1
      UniProtKB/TrEMBL
      G3X9M3, Q6PEF4
      Related
      ENSMUSP00000089498.5, ENSMUST00000091884.6
      Conserved Domains (1) summary
      smart00398
      Location:40 → 99
      HMG; high mobility group

    2. NM_178277.1 → NP_840061.1  HMG domain-containing protein 3 isoform 1

      See identical proteins and their annotated locations for NP_840061.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. It encodes the longer protein (isoform 1).
      Source sequence(s)
      AB045322, BC025148, BC058089
      Consensus CDS
      CCDS89249.1
      UniProtKB/TrEMBL
      Q6AXF8, Q6PEF4
      Related
      ENSMUSP00000158376.2, ENSMUST00000235480.2
      Conserved Domains (1) summary
      smart00398
      Location:40 → 99
      HMG; high mobility group

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      61264349..61310122 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017317779.1 → XP_017173268.1  HMG domain-containing protein 3 isoform X1

      UniProtKB/TrEMBL
      Q6NZP6, Q9JJ64
      Conserved Domains (1) summary
      pfam18717
      Location:318 → 392
      CxC4; CxC4 like cysteine cluster associated with KDZ transposases
    Nucleotide Protein Strain
    Heading Accession and Version

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