Nlrp4b NLR family, pyrin domain containing 4B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nlrp4bprovided by MGI
Official Full Name: NLR family, pyrin domain containing 4Bprovided by MGI
Primary source: MGI:MGI:3056570
See related: Ensembl:ENSMUSG00000034087 AllianceGenome:MGI:3056570
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Nalp4b; E330024M09; Nalp-gamma
Summary: Predicted to enable molecular adaptor activity. Predicted to be involved in negative regulation of innate immune response and regulation of inflammatory response. Predicted to be active in cytoplasm. Is expressed in ovary. Orthologous to human NLRP4 (NLR family pyrin domain containing 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Low expression observed in reference dataset See more
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Genomic context

Location:: 7 A1; 7 6.58 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (10421720..10464095)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (10687793..10730168)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

D7Ertd595e (e-PCR), detects polymorphism
- UniSTS:167531

Nlrp4b (e-PCR), detects polymorphism
- UniSTS:526826

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables molecular adaptor activity	ISO Inferred from Sequence Orthology more info
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of innate immune response	ISO Inferred from Sequence Orthology more info
involved_in regulation of inflammatory response	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: NACHT, LRR and PYD domains-containing protein 4B

Names: NACHT, leucine rich repeat and PYD containing 4B; NACHT/LRR/pyrin domain-containing protein 4b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001355151.1 → NP_001342080.1 NACHT, LRR and PYD domains-containing protein 4B

Status: VALIDATED

Source sequence(s)

AC151720

Consensus CDS

CCDS20795.1

UniProtKB/Swiss-Prot

Q66X16, Q8C6J9

UniProtKB/TrEMBL

Q6NY05

Related

ENSMUSP00000113095.2, ENSMUST00000117413.9

Conserved Domains (4) summary

cd08320
Location:10 → 93

Pyrin_NALPs; Pyrin death domain found in NALP proteins

sd00033
Location:715 → 742

LRR_RI; leucine-rich repeat [structural motif]

pfam05729
Location:145 → 311

NACHT; NACHT domain

cl26161
Location:601 → 834

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
NM_172481.2 → NP_766069.1 NACHT, LRR and PYD domains-containing protein 4B

See identical proteins and their annotated locations for NP_766069.1

Status: VALIDATED

Source sequence(s)

AK054426

Consensus CDS

CCDS20795.1

UniProtKB/Swiss-Prot

Q66X16, Q8C6J9

UniProtKB/TrEMBL

Q6NY05

Related

ENSMUSP00000043881.5, ENSMUST00000047809.11

Conserved Domains (4) summary

cd08320
Location:10 → 93

Pyrin_NALPs; Pyrin death domain found in NALP proteins

sd00033
Location:715 → 742

LRR_RI; leucine-rich repeat [structural motif]

pfam05729
Location:145 → 311

NACHT; NACHT domain

cl26161
Location:601 → 834

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...