Cckbr cholecystokinin B receptor [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cckbrprovided by MGI
Official Full Name: cholecystokinin B receptorprovided by MGI
Primary source: MGI:MGI:99479
See related: Ensembl:ENSMUSG00000030898 AllianceGenome:MGI:99479
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CCK2R; CCK-BR; CCK2-R; CCKR-2
Summary: This gene encodes a multipass transmembrane receptor protein expressed in the central nervous system and gastrointestinal tract. Cholecystokinin and gastrin bind to the encoded protein to stimulate gastric acid secretion and mucosal growth in the gastrointestinal tract, and anxiety, pain sensation and memory in the brain. Mice lacking the encoded protein exhibit an increase in the basal gastric pH and gastrin levels in the bloodstream as well as mild hypocalcemia, secondary hyperparathyroidism and increased bone resorption. [provided by RefSeq, Apr 2015]
Expression: Biased expression in cortex adult (RPKM 23.1), frontal lobe adult (RPKM 18.4) and 3 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 E3; 7 55.86 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (105075201..105085546)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (105425676..105436339)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Implicating the cholecystokinin B receptor in liver stem cell oncogenesis.
Title: Implicating the cholecystokinin B receptor in liver stem cell oncogenesis.
CCK2-receptor deficiency impairs immune balance by influencing CD4[+] T cells development by inhibiting cortical-thymic-epithelial-cells.
Title: CCK2-receptor deficiency impairs immune balance by influencing CD4(+) T cells development by inhibiting cortical-thymic-epithelial-cells.
Deterioration of apatite orientation in the cholecystokinin B receptor gene (Cckbr)-deficient mouse femurs.
Title: Deterioration of apatite orientation in the cholecystokinin B receptor gene (Cckbr)-deficient mouse femurs.
Effect of GRK4 on renal gastrin receptor regulation in hypertension.
Title: Effect of GRK4 on renal gastrin receptor regulation in hypertension.
Intestinal Gastrin/CCKBR (Cholecystokinin B Receptor) Ameliorates Salt-Sensitive Hypertension by Inhibiting Intestinal Na(+)/H(+) Exchanger 3 Activity Through a PKC (Protein Kinase C)-Mediated NHERF1 and NHERF2 Pathway.
Title: Intestinal Gastrin/CCKBR (Cholecystokinin B Receptor) Ameliorates Salt-Sensitive Hypertension by Inhibiting Intestinal Na(+)/H(+) Exchanger 3 Activity Through a PKC (Protein Kinase C)-Mediated NHERF1 and NHERF2 Pathway.
weevaluated the chemopreventive potential of two CCK2R antagonists,JNJ-26070109 and YF476, against pancreatic cancer using the genetically engineered mice
Title: Targeting cholecystokinin-2 receptor for pancreatic cancer chemoprevention.
Our data suggest a progression model for BE to EAC in which CCK2R+ progenitor cells, stimulated by hypergastrinemia, proliferate to give rise to metaplasia and dysplasia.
Title: Gastrin stimulates a cholecystokinin-2-receptor-expressing cardia progenitor cell and promotes progression of Barrett's-like esophagus.
CCKBR and D5R synergistically interact in the kidney, which may contribute to the maintenance of normal sodium balance following an increase in sodium intake
Title: The Synergistic Roles of Cholecystokinin B and Dopamine D5 Receptors on the Regulation of Renal Sodium Excretion.
findings provide novel evidence that Cnr1 contributes to cued fear expression via an interaction with the CCKB receptor.
Title: Interaction between the cholecystokinin and endogenous cannabinoid systems in cued fear expression and extinction retention.
There is functional synergy between cholecystokinin receptors CCKAR and CCKBR in mammalian brain development.
Title: Functional synergy between cholecystokinin receptors CCKAR and CCKBR in mammalian brain development.

Submit: New GeneRIF Correction See all GeneRIFs (39)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5)
Targeted (3) 1 citation

General gene information

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Markers

Cckbr (e-PCR), detects polymorphism
- UniSTS:265053

Cckbr (e-PCR), detects polymorphism
- UniSTS:265054

Cckbr (e-PCR), detects polymorphism
- UniSTS:265055

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cholecystokinin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables cholecystokinin receptor activity	IEA Inferred from Electronic Annotation more info
enables gastrin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables gastrin receptor activity	ISO Inferred from Sequence Orthology more info
enables gastrin receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables neuropeptide receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables peptide hormone binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables type B gastrin/cholecystokinin receptor binding	IEA Inferred from Electronic Annotation more info
enables type B gastrin/cholecystokinin receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in behavioral defense response	ISO Inferred from Sequence Orthology more info
involved_in cholecystokinin signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within digestive tract development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in estrous cycle	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within gastric acid secretion	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within gastric acid secretion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within gland development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in histamine secretion	ISO Inferred from Sequence Orthology more info
involved_in neuropeptide signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within pH reduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of behavioral fear response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytosolic calcium ion concentration	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of somatostatin secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of synaptic transmission, GABAergic	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of synaptic transmission, glutamatergic	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in intracellular membrane-bounded organelle	IEA Inferred from Electronic Annotation more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: gastrin/cholecystokinin type B receptor

Names: CCK-B receptor; CCK-B/gastrin receptor; CCK2/gastrin receptor; cholecystokinin-2 receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001412224.1 → NP_001399153.1 gastrin/cholecystokinin type B receptor isoform 2

Status: REVIEWED

Source sequence(s)

AC125055
NM_007627.6 → NP_031653.1 gastrin/cholecystokinin type B receptor isoform 1

See identical proteins and their annotated locations for NP_031653.1

Status: REVIEWED

Source sequence(s)

AC125055

Consensus CDS

CCDS21651.1

UniProtKB/Swiss-Prot

P56481

UniProtKB/TrEMBL

Q3ZB46, Q8BKF6

Related

ENSMUSP00000033189.4, ENSMUST00000033189.6

Conserved Domains (2) summary

pfam00001
Location:71 → 396

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:60 → 191

7tm_4; Olfactory receptor