Trim12c tripartite motif-containing 12C [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Trim12cprovided by MGI
Official Full Name: tripartite motif-containing 12Cprovided by MGI
Primary source: MGI:MGI:4821183
See related: Ensembl:ENSMUSG00000057143 AllianceGenome:MGI:4821183
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Trim12-2; 9230105E10Rik
Summary: Predicted to enable several functions, including protein homodimerization activity; transcription coactivator activity; and ubiquitin protein ligase activity. Predicted to be involved in several processes, including defense response to symbiont; positive regulation of NF-kappaB transcription factor activity; and regulation of signal transduction. Predicted to be located in P-body. Predicted to be active in cytosol and nucleoplasm. Predicted to colocalize with omegasome. Is expressed in genitourinary system. Orthologous to human TRIM5 (tripartite motif containing 5). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in bladder adult (RPKM 5.3), thymus adult (RPKM 3.9) and 28 other tissues See more
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Genomic context

Location:: 7 E3; 7 55.69 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (103987961..104002649, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (104338754..104353358, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This study identifies TRIM12c as a mouse TRIM5 equivalent, critical for host innate immunity.
Title: Tripartite Motif (TRIM) 12c, a Mouse Homolog of TRIM5, Is a Ubiquitin Ligase That Stimulates Type I IFN and NF-κB Pathways along with TNFR-Associated Factor 6.
describe an expanded paralogous cluster of at least eight Trim5-like genes in mice
Title: An expanded clade of rodent Trim5 genes.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

General gene information

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Markers

D7Mit217 (e-PCR), detects polymorphism
- UniSTS:131109

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables pattern recognition receptor activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein-macromolecule adaptor activity	ISO Inferred from Sequence Orthology more info
enables transcription coactivator activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin-protein transferase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in activation of innate immune response	ISO Inferred from Sequence Orthology more info
involved_in autophagy	ISO Inferred from Sequence Orthology more info
involved_in innate immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in innate immune response	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of viral entry into host cell	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical NF-kappaB signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in protein K63-linked ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of lipopolysaccharide-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein localization	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of protein localization	ISO Inferred from Sequence Orthology more info
involved_in regulation of viral entry into host cell	IBA Inferred from Biological aspect of Ancestor more info
involved_in suppression of viral release by host	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in P-body	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
colocalizes_with omegasome	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: tripartite motif-containing 12C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001146007.1 → NP_001139479.1 tripartite motif-containing 12C

See identical proteins and their annotated locations for NP_001139479.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.

Source sequence(s)

AC142110, AK050485

Consensus CDS

CCDS52344.1

UniProtKB/TrEMBL

D3Z3L3, E9Q987, Q8CHU6

Related

ENSMUSP00000060100.9, ENSMUST00000059037.15

Conserved Domains (4) summary

smart00336
Location:96 → 132

BBOX; B-Box-type zinc finger

pfam14265
Location:164 → 234

DUF4355; Domain of unknown function (DUF4355)

pfam15227
Location:15 → 58

zf-C3HC4_4; zinc finger of C3HC4-type, RING

cd15822
Location:289 → 493

SPRY_PRY_TRIM5; PRY/SPRY domain in tripartite motif-binding protein 5 (TRIM5), also known as RING finger protein 88 (RNF88)
NM_175677.4 → NP_783608.3 tripartite motif-containing 12C

See identical proteins and their annotated locations for NP_783608.3

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.

Source sequence(s)

AC142110, AK050485, BU923784

Consensus CDS

CCDS52344.1

UniProtKB/TrEMBL

D3Z3L3, E9Q987, Q8CHU6

Related

ENSMUSP00000116775.3, ENSMUST00000130139.3

Conserved Domains (4) summary

smart00336
Location:96 → 132

BBOX; B-Box-type zinc finger

pfam14265
Location:164 → 234

DUF4355; Domain of unknown function (DUF4355)

pfam15227
Location:15 → 58

zf-C3HC4_4; zinc finger of C3HC4-type, RING

cd15822
Location:289 → 493

SPRY_PRY_TRIM5; PRY/SPRY domain in tripartite motif-binding protein 5 (TRIM5), also known as RING finger protein 88 (RNF88)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

103987961..104002649 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036153162.1 → XP_036009055.1 tripartite motif-containing 12C isoform X1

UniProtKB/TrEMBL

Q8CC73

Conserved Domains (4) summary

COG4372
Location:119 → 308

COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]

cd00162
Location:15 → 58

RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]

cd19761
Location:96 → 133

Bbox2_TRIM5-like; B-box-type 2 zinc finger found in tripartite motif-containing proteins, TRIM5, TRIM6, TRIM22, TRIM34, TRIM38 and similar proteins

cl17238
Location:12 → 59

RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain