Mast1 microtubule associated serine/threonine kinase 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mast1provided by MGI
Official Full Name: microtubule associated serine/threonine kinase 1provided by MGI
Primary source: MGI:MGI:1861901
See related: Ensembl:ENSMUSG00000053693 AllianceGenome:MGI:1861901
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: SAST; SAST170; 9430008B02Rik
Summary: Enables microtubule binding activity. Involved in brain development and cytoskeleton organization. Located in membrane; neuron projection; and neuronal cell body. Is expressed in nervous system; neural retina; and skeletal muscle. Used to study mega-corpus-callosum syndrome with cerebellar hypoplasia and cortical malformations. Human ortholog(s) of this gene implicated in female breast cancer and mega-corpus-callosum syndrome with cerebellar hypoplasia and cortical malformations. Orthologous to human MAST1 (microtubule associated serine/threonine kinase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in whole brain E14.5 (RPKM 40.5), CNS E18 (RPKM 36.2) and 6 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 C3; 8 41.32 cM

Exon count:: 27

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (85638482..85672811, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (84911853..84946177, complement)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mast1 mediates radiation-induced gastric injury via the P38 MAPK pathway.
Title: Mast1 mediates radiation-induced gastric injury via the P38 MAPK pathway.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 3-phosphoinositide-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	ISS Inferred from Sequence or Structural Similarity more info
enables DNA-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables Rho-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables eukaryotic translation initiation factor 2alpha kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS121 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AT120 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS139 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS14 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS36 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S28 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S57 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T11 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T3 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T45 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T6 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H4S1 kinase activity	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables microtubule binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables ribosomal protein S6 kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in brain development	IBA Inferred from Biological aspect of Ancestor more info
involved_in brain development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in brain development	ISO Inferred from Sequence Orthology more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in cytoskeleton organization	IDA Inferred from Direct Assay more info	PubMed
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein phosphorylation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in axon	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in dendrite	IEA Inferred from Electronic Annotation more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in neuron projection	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: microtubule-associated serine/threonine-protein kinase 1

Names: syntrophin associated serine/threonine kinase; syntrophin-associated serine-threonine protein kinase

NP_064329.2

EC 2.7.11.1

XP_006531279.1

EC 2.7.11.1

XP_006531280.1

EC 2.7.11.1

XP_030099555.1

EC 2.7.11.1

XP_036010090.1

EC 2.7.11.1

XP_036010091.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019945.2 → NP_064329.2 microtubule-associated serine/threonine-protein kinase 1

Status: VALIDATED

Source sequence(s)

AY312167, BC054524, BU701555

Consensus CDS

CCDS40415.1

UniProtKB/Swiss-Prot

Q7TQG9, Q80TN0, Q9R1L5

Related

ENSMUSP00000105363.3, ENSMUST00000109741.9

Conserved Domains (4) summary

PHA03247
Location:1205 → 1566

PHA03247; large tegument protein UL36; Provisional

cd00992
Location:970 → 1052

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd05609
Location:375 → 654

STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase

pfam08926
Location:61 → 337

DUF1908; Domain of unknown function (DUF1908)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

85638482..85672811 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036154197.1 → XP_036010090.1 microtubule-associated serine/threonine-protein kinase 1 isoform X1

UniProtKB/Swiss-Prot

Q7TQG9, Q80TN0, Q9R1L5

Conserved Domains (4) summary

PHA03247
Location:1205 → 1566

PHA03247; large tegument protein UL36; Provisional

cd00992
Location:970 → 1052

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd05609
Location:375 → 654

STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase

pfam08926
Location:61 → 337

DUF1908; Domain of unknown function (DUF1908)
XM_006531216.5 → XP_006531279.1 microtubule-associated serine/threonine-protein kinase 1 isoform X3

Conserved Domains (4) summary

PHA03247
Location:1201 → 1562

PHA03247; large tegument protein UL36; Provisional

cd00992
Location:966 → 1048

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd05609
Location:371 → 650

STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase

pfam08926
Location:57 → 333

DUF1908; Domain of unknown function (DUF1908)
XM_006531217.5 → XP_006531280.1 microtubule-associated serine/threonine-protein kinase 1 isoform X2

Conserved Domains (4) summary

PHA03247
Location:1200 → 1561

PHA03247; large tegument protein UL36; Provisional

cd00992
Location:965 → 1047

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd05609
Location:370 → 649

STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase

pfam08926
Location:56 → 332

DUF1908; Domain of unknown function (DUF1908)
XM_030243695.1 → XP_030099555.1 microtubule-associated serine/threonine-protein kinase 1 isoform X4

Conserved Domains (2) summary

PHA03247
Location:497 → 858

PHA03247; large tegument protein UL36; Provisional

cd00992
Location:262 → 344

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
XM_036154198.1 → XP_036010091.1 microtubule-associated serine/threonine-protein kinase 1 isoform X4

Conserved Domains (2) summary

PHA03247
Location:497 → 858

PHA03247; large tegument protein UL36; Provisional

cd00992
Location:262 → 344

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...