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    RPL4A ribosomal 60S subunit protein L4A [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852319, updated on 9-Dec-2024

    Summary

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    Official Symbol
    RPL4A
    Official Full Name
    ribosomal 60S subunit protein L4A
    Primary source
    SGD:S000000235
    Locus tag
    YBR031W
    See related
    AllianceGenome:SGD:S000000235; FungiDB:YBR031W; VEuPathDB:YBR031W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable RNA binding activity. Predicted to be a structural constituent of ribosome. Predicted to be involved in cytoplasmic translation. Part of cytosolic large ribosomal subunit. Orthologous to human RPL4 (ribosomal protein L4). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See RPL4A in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (300166..301254)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene phosphatidate cytidylyltransferase Neighboring gene protein-lysine N-methyltransferase Neighboring gene uncharacterized protein Neighboring gene Eds1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Deletion of L4 domains reveals insights into the importance of ribosomal protein extensions in eukaryotic ribosome assembly. Gamalinda M, et al. RNA, 2014 Nov. PMID 25246649, Free PMC Article
    2. The ribosomal protein L2 in S. cerevisiae controls the level of accumulation of its own mRNA. Presutti C, et al. EMBO J, 1991 Aug. PMID 2065661, Free PMC Article
    3. Ribosomal protein L2 in Saccharomyces cerevisiae is homologous to ribosomal protein L1 in Xenopus laevis. Isolation and characterization of the genes. Presutti C, et al. J Biol Chem, 1988 May 5. PMID 2834365
    4. Gene dosage alteration of L2 ribosomal protein genes in Saccharomyces cerevisiae: effects on ribosome synthesis. Lucioli A, et al. Mol Cell Biol, 1988 Nov. PMID 3062369, Free PMC Article
    5. Identification of the cis-elements mediating the autogenous control of ribosomal protein L2 mRNA stability in yeast. Presutti C, et al. EMBO J, 1995 Aug 15. PMID 7664741, Free PMC Article

    See all (177) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results show that the internal loop of L4 is important for efficient formation of large subunits; deleting this loop affects very late stages in pre-60S ribosome assembly.
      Title: Deletion of L4 domains reveals insights into the importance of ribosomal protein extensions in eukaryotic ribosome assembly.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome IC
    Inferred by Curator
    more info
    		 PubMed 
    enables structural constituent of ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoplasmic translation IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of cytosolic large ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytosolic large ribosomal subunit IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ribosomal 60S subunit protein L4A
    NP_009587.1
    • Ribosomal 60S subunit protein L4A; N-terminally acetylated; homologous to mammalian ribosomal protein L4 and bacterial L4; RPL4A has a paralog, RPL4B, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      300166..301254
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178379.1 → NP_009587.1  TPA: ribosomal 60S subunit protein L4A [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009587.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQ32, P10664
      UniProtKB/TrEMBL
      A6ZKX6, B3LNB3, C7GXY0, D3UEC7, G2W937
      Conserved Domains (1) summary
      PTZ00428
      Location:2 → 350
      PTZ00428; 60S ribosomal protein L4; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P10664.4

    Gene LinkOut

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