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    ICL1 isocitrate lyase 1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856794, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ICL1
    Official Full Name
    isocitrate lyase 1
    Primary source
    SGD:S000000867
    Locus tag
    YER065C
    See related
    AllianceGenome:SGD:S000000867; FungiDB:YER065C; VEuPathDB:YER065C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables isocitrate lyase activity. Involved in glyoxylate cycle. Located in cytoplasm. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ICL1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    1
    Sequence:
    Chromosome: V; NC_001137.3 (285241..286914, complement)

    Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene Tho1p Neighboring gene Vhr2p Neighboring gene tRNA-Ser Neighboring gene Rrt13p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001137.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The ICL1 gene from Saccharomyces cerevisiae. Fernández E, et al. Eur J Biochem, 1992 Mar 15. PMID 1551398
    2. A 27 kDa protein binds to a positive and a negative regulatory sequence in the promoter of the ICL1 gene from Saccharomyces cerevisiae. Ordiz I, et al. Biochem J, 1998 Jan 15. PMID 9425123, Free PMC Article
    3. Isocitrate lyase localisation in Saccharomyces cerevisiae cells. Chaves RS, et al. Gene, 1997 Oct 1. PMID 9370278
    4. Localization and targeting of isocitrate lyases in Saccharomyces cerevisiae. Taylor KM, et al. Biochem J, 1996 Oct 1. PMID 8870676, Free PMC Article
    5. PTS1-independent targeting of isocitrate lyase to peroxisomes requires the PTS1 receptor Pex5p. Parkes JA, et al. Mol Membr Biol, 2003 Jan-Mar. PMID 12745927

    See all (73) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables isocitrate lyase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables isocitrate lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables isocitrate lyase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methylisocitrate lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in carboxylic acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glyoxylate cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glyoxylate cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in monocarboxylic acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tricarboxylic acid cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuole IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    isocitrate lyase 1
    NP_010987.3
    • Isocitrate lyase; catalyzes the formation of succinate and glyoxylate from isocitrate, a key reaction of the glyoxylate cycle; expression of ICL1 is induced by growth on ethanol and repressed by growth on glucose

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001137.3 Reference assembly

      Range
      285241..286914 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178956.3 → NP_010987.3  TPA: isocitrate lyase 1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010987.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DLX0, P28240
      UniProtKB/TrEMBL
      A6ZR19, B3LRI2, C7GTD3, C8Z771, G2WCV4
      Conserved Domains (1) summary
      pfam00463
      Location:22 → 550
      ICL; Isocitrate lyase family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P28240.1

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