Meis1 Meis homeobox 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Meis1provided by MGI
Official Full Name: Meis homeobox 1provided by MGI
Primary source: MGI:MGI:104717
See related: Ensembl:ENSMUSG00000020160 AllianceGenome:MGI:104717
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Evi8; C530044H18Rik
Summary: Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Involved in negative regulation of myeloid cell differentiation and positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including angiogenesis; hemopoiesis; and lens morphogenesis in camera-type eye. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; genitourinary system; and sensory organ. Used to study restless legs syndrome. Orthologous to human MEIS1 (Meis homeobox 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in bladder adult (RPKM 25.6), CNS E11.5 (RPKM 9.3) and 19 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 A3.1; 11 11.11 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (18830428..18968992, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (18880428..19019651, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Meis1 Targets Protein Tyrosine Phosphatase Receptor J in Fibroblast to Retard Chronic Kidney Disease Progression.
Title: Meis1 Targets Protein Tyrosine Phosphatase Receptor J in Fibroblast to Retard Chronic Kidney Disease Progression.
A patient-enriched MEIS1 coding variant causes a restless legs syndrome-like phenotype in mice.
Title: A patient-enriched MEIS1 coding variant causes a restless legs syndrome-like phenotype in mice.
Npm1 haploinsufficiency in collaboration with MEIS1 is sufficient to induce AML in mice.
Title: Npm1 haploinsufficiency in collaboration with MEIS1 is sufficient to induce AML in mice.
A pro B cell population forms the apex of the leukemic hierarchy in Hoxa9/Meis1-dependent AML.
Title: A pro B cell population forms the apex of the leukemic hierarchy in Hoxa9/Meis1-dependent AML.
Transcription factor Meis1 act as a new regulator of ischemic arrhythmias in mice.
Title: Transcription factor Meis1 act as a new regulator of ischemic arrhythmias in mice.
Meis1 plays roles in cortical development through regulation of cellular proliferative capacity in the embryonic cerebrum.
Title: Meis1 plays roles in cortical development through regulation of cellular proliferative capacity in the embryonic cerebrum.
Homeobox transcription factor Meis1 is crucial to Sertoli cell mediated regulation of male fertility.
Title: Homeobox transcription factor Meis1 is crucial to Sertoli cell mediated regulation of male fertility.
Investigation of dopaminergic signalling in Meis homeobox 1 (Meis1) deficient mice as an animal model of restless legs syndrome.
Title: Investigation of dopaminergic signalling in Meis homeobox 1 (Meis1) deficient mice as an animal model of restless legs syndrome.
MEIS-WNT5A axis regulates development of fourth ventricle choroid plexus.
Title: MEIS-WNT5A axis regulates development of fourth ventricle choroid plexus.
Control of mouse limb initiation and antero-posterior patterning by Meis transcription factors.
Title: Control of mouse limb initiation and antero-posterior patterning by Meis transcription factors.

Submit: New GeneRIF Correction See all GeneRIFs (79)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5) 1 citation
Targeted (12) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC343796P1 (e-PCR)
- UniSTS:273190

MEIS1_7825 (e-PCR)
- UniSTS:466310

NIB1519 (e-PCR)
- UniSTS:23259

Meis1 (e-PCR), detects polymorphism
- UniSTS:143855

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific DNA binding	IGI Inferred from Genetic Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in angiogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in animal organ morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within blood vessel morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in brain development	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell growth involved in cardiac muscle cell development	IEA Inferred from Electronic Annotation more info
involved_in cell growth involved in cardiac muscle cell development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within definitive hemopoiesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryonic pattern specification	IBA Inferred from Biological aspect of Ancestor more info
involved_in eye development	IBA Inferred from Biological aspect of Ancestor more info
involved_in hemopoiesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within hemopoiesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lens morphogenesis in camera-type eye	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within megakaryocyte development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of myeloid cell differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of neuron differentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	IC Inferred by Curator more info	PubMed

Component	Evidence Code	Pubs
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
part_of transcription regulator complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: homeobox protein Meis1

Names: myeloid ecotropic viral integration site 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001193271.1 → NP_001180200.1 homeobox protein Meis1 isoform B

See identical proteins and their annotated locations for NP_001180200.1

Status: VALIDATED

Description

Transcript Variant: : This variant (B) includes an alternate exon in the 3' coding region, which results in a frameshift, compared to variant A. The resulting protein (isoform B) has a shorter and distinct C-terminus, compared to isoform A.

Source sequence(s)

AK140748, AL645570

Consensus CDS

CCDS56760.1

UniProtKB/Swiss-Prot

B1ARH5, Q5SVC8, Q60954, Q60955, Q8CIL0

UniProtKB/TrEMBL

H3BLB6

Related

ENSMUSP00000069277.8, ENSMUST00000068264.14

Conserved Domains (2) summary

pfam05920
Location:290 → 329

Homeobox_KN; Homeobox KN domain

pfam16493
Location:108 → 192

Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
NM_010789.3 → NP_034919.1 homeobox protein Meis1 isoform A

See identical proteins and their annotated locations for NP_034919.1

Status: VALIDATED

Description

Transcript Variant: This variant (A) encodes the longer isoform (A).

Source sequence(s)

AL603984, AL645570

Consensus CDS

CCDS24453.1

UniProtKB/TrEMBL

H3BLB6

Related

ENSMUSP00000139219.2, ENSMUST00000185131.8

Conserved Domains (2) summary

pfam05920
Location:290 → 329

Homeobox_KN; Homeobox KN domain

pfam16493
Location:108 → 191

Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

18830428..18968992 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017314312.3 → XP_017169801.1 homeobox protein Meis1 isoform X2

UniProtKB/TrEMBL

H3BLB6

Conserved Domains (2) summary

pfam05920
Location:241 → 280

Homeobox_KN; Homeobox KN domain

pfam16493
Location:108 → 161

Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
XM_006514559.5 → XP_006514622.1 homeobox protein Meis1 isoform X1

Conserved Domains (3) summary

TIGR01628
Location:277 → 408

PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family

pfam05920
Location:241 → 280

Homeobox_KN; Homeobox KN domain

pfam16493
Location:108 → 161

Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
XM_030245628.2 → XP_030101488.1 homeobox protein Meis1 isoform X3

UniProtKB/TrEMBL

Q3UJ00

Related

ENSMUST00000118661.8

Conserved Domains (2) summary

pfam05920
Location:146 → 185

Homeobox_KN; Homeobox KN domain

pfam16493
Location:1 → 48

Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1