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    Wdr73 WD repeat domain 73 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 308751, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Wdr73provided by RGD
    Official Full Name
    WD repeat domain 73provided by RGD
    Primary source
    RGD:1306429
    See related
    EnsemblRapid:ENSRNOG00000010664 AllianceGenome:RGD:1306429
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in cytoplasmic microtubule organization; negative regulation of apoptotic process; and nucleus organization. Predicted to be located in cleavage furrow. Predicted to colocalize with cytosol and spindle pole. Human ortholog(s) of this gene implicated in Galloway-Mowat syndrome 1. Orthologous to human WDR73 (WD repeat domain 73). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 55.0), Brain (RPKM 46.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Wdr73 in Genome Data Viewer
    Location:
    1q31
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (144269561..144277707, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (134860329..134868475, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (142711955..142720292, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene IQ motif containing GTPase activating protein 1 Neighboring gene zinc finger and SCAN domain containing 2 Neighboring gene ribosomal protein L26-like 1, pseudogene 1 Neighboring gene neuromedin B Neighboring gene SEC11 homolog A, signal peptidase complex subunit

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Loss-of-function mutations in WDR73 are responsible for microcephaly and steroid-resistant nephrotic syndrome: Galloway-Mowat syndrome. Colin E, et al. Am J Hum Genet, 2014 Dec 4. PMID 25466283, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in cytoplasmic microtubule organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cytoplasmic microtubule organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nucleus organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cleavage furrow ISO
    Inferred from Sequence Orthology
    more info
    		  
    colocalizes_with cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    colocalizes_with spindle pole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in spindle pole ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    WD repeat-containing protein 73

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107525.2 → NP_001100995.1  WD repeat-containing protein 73

      See identical proteins and their annotated locations for NP_001100995.1

      Status: PROVISIONAL

      Source sequence(s)
      BC158658
      UniProtKB/TrEMBL
      B0BN27, F7EST6
      Related
      ENSRNOP00000029102.5, ENSRNOT00000032294.6
      Conserved Domains (2) summary
      COG2319
      Location:43 → 364
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:279 → 325
      7WD40; WD40 repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      144269561..144277707 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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