Pglyrp1 peptidoglycan recognition protein 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pglyrp1provided by RGD
Official Full Name: peptidoglycan recognition protein 1provided by RGD
Primary source: RGD:621429
See related: EnsemblRapid:ENSRNOG00000013395 AllianceGenome:RGD:621429
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Pgrp; Pglyrp
Summary: Predicted to enable several functions, including Hsp70 protein binding activity; peptidoglycan binding activity; and peptidoglycan immune receptor activity. Involved in regulation of circadian sleep/wake cycle, sleep. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Orthologous to human PGLYRP1 (peptidoglycan recognition protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Adrenal (RPKM 32.1), Spleen (RPKM 28.7) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q21

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (87659863..87665048)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (78531815..78537001)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (79790879..79796064)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables Hsp70 protein binding	ISO Inferred from Sequence Orthology more info
enables N-acetylmuramoyl-L-alanine amidase activity	IEA Inferred from Electronic Annotation more info
enables molecular adaptor activity	ISO Inferred from Sequence Orthology more info
enables peptidoglycan binding	IBA Inferred from Biological aspect of Ancestor more info
enables peptidoglycan binding	IEA Inferred from Electronic Annotation more info
enables peptidoglycan binding	ISO Inferred from Sequence Orthology more info
enables peptidoglycan binding	ISS Inferred from Sequence or Structural Similarity more info
enables peptidoglycan immune receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables peptidoglycan immune receptor activity	ISO Inferred from Sequence Orthology more info
enables peptidoglycan immune receptor activity	TAS Traceable Author Statement more info	PubMed
enables receptor ligand activity	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide	ISO Inferred from Sequence Orthology more info
involved_in biological process involved in interaction with host	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within biological process involved in interaction with host	ISO Inferred from Sequence Orthology more info
involved_in defense response to Gram-positive bacterium	ISO Inferred from Sequence Orthology more info
involved_in defense response to bacterium	IBA Inferred from Biological aspect of Ancestor more info
involved_in defense response to bacterium	IEA Inferred from Electronic Annotation more info
involved_in detection of bacterium	ISO Inferred from Sequence Orthology more info
involved_in immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in immune response	TAS Traceable Author Statement more info	PubMed
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of inflammatory response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of natural killer cell differentiation involved in immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of natural killer cell differentiation involved in immune response	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of type II interferon production	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of type II interferon production	ISO Inferred from Sequence Orthology more info
involved_in peptidoglycan catabolic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of circadian sleep/wake cycle, sleep	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to bacterium	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: peptidoglycan recognition protein 1

Names: PGRP-S

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053373.1 → NP_445825.1 peptidoglycan recognition protein 1 precursor

See identical proteins and their annotated locations for NP_445825.1

Status: PROVISIONAL

Source sequence(s)

AF154114

UniProtKB/Swiss-Prot

Q9JLN4

UniProtKB/TrEMBL

A6J8I2, G3V7R2

Related

ENSRNOP00000018233.2, ENSRNOT00000018233.5

Conserved Domains (1) summary

smart00701
Location:21 → 161

PGRP; Animal peptidoglycan recognition proteins homologous to Bacteriophage T3 lysozyme