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    Ndufs7 NADH:ubiquinone oxidoreductase core subunit S7 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362837, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Ndufs7provided by RGD
    Official Full Name
    NADH:ubiquinone oxidoreductase core subunit S7provided by RGD
    Primary source
    RGD:1310013
    See related
    AllianceGenome:RGD:1310013
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables protease binding activity. Predicted to be involved in electron transport coupled proton transport; mitochondrial electron transport, NADH to ubiquinone; and mitochondrial respiratory chain complex I assembly. Located in neuronal cell body and synaptic membrane. Human ortholog(s) of this gene implicated in developmental disorder of mental health and nuclear type mitochondrial complex I deficiency 3. Orthologous to human NDUFS7 (NADH:ubiquinone oxidoreductase core subunit S7). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Muscle (RPKM 1089.7), Heart (RPKM 1047.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ndufs7 in Genome Data Viewer
    Location:
    7q11
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (10103226..10110862, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (9452556..9460135, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (12318776..12326403, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene DAZ associated protein 1 Neighboring gene guanidinoacetate N-methyltransferase Neighboring gene transfer RNA asparagine (anticodon GUU) 8 Neighboring gene transfer RNA phenylalanine (anticodon GAA) 3 Neighboring gene PWWP domain containing 3A, DNA repair factor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification of two novel synaptic γ-secretase associated proteins that affect amyloid β-peptide levels without altering Notch processing. Frykman S, et al. Neurochem Int, 2012 Jul. PMID 22521230
    2. Mitochondrial complex I activity and oxidative damage to mitochondrial proteins in the prefrontal cortex of patients with bipolar disorder. Andreazza AC, et al. Arch Gen Psychiatry, 2010 Apr. PMID 20368511
    3. Proteomic and metabolomic analyses of mitochondrial complex I-deficient mouse model generated by spontaneous B2 short interspersed nuclear element (SINE) insertion into NADH dehydrogenase (ubiquinone) Fe-S protein 4 (Ndufs4) gene. Leong DW, et al. J Biol Chem, 2012 Jun 8. PMID 22535952, Free PMC Article
    4. Differences in assembly or stability of complex I and other mitochondrial OXPHOS complexes in inherited complex I deficiency. Ugalde C, et al. Hum Mol Genet, 2004 Mar 15. PMID 14749350
    5. Mutation burden analysis of six common mental disorders in African Americans by whole genome sequencing. Liu Y, et al. Hum Mol Genet, 2022 Nov 10. PMID 35642741

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC105684

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 4 iron, 4 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NADH dehydrogenase (ubiquinone) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables NADH dehydrogenase (ubiquinone) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    contributes_to NADH dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protease binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables quinone binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in aerobic respiration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in electron transport coupled proton transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial electron transport, NADH to ubiquinone ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrial respiratory chain complex I assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial respiratory chain complex I assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of respiratory chain complex I IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of respiratory chain complex I ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in synaptic membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial
    Names
    NADH dehydrogenase (ubiquinone) Fe-S protein 7
    NADH-ubiquinone oxidoreductase Fe-S protein 7
    NP_001008525.1
    XP_006241034.1
    XP_038935332.1
    XP_038935333.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008525.1 → NP_001008525.1  NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial

      See identical proteins and their annotated locations for NP_001008525.1

      Status: PROVISIONAL

      Source sequence(s)
      BC086574
      UniProtKB/TrEMBL
      A0A8I6AES7, A0A8I6B2Z5, A6K8N6, Q5RJN0
      Conserved Domains (1) summary
      PRK06411
      Location:68 → 218
      PRK06411; NADH dehydrogenase subunit B; Validated

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      10103226..10110862 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006240972.5 → XP_006241034.1  NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial isoform X2

      See identical proteins and their annotated locations for XP_006241034.1

      UniProtKB/TrEMBL
      A0A8I6AES7, A0A8I6B2Z5, A6K8N6, Q5RJN0
      Conserved Domains (1) summary
      PRK06411
      Location:68 → 218
      PRK06411; NADH dehydrogenase subunit B; Validated

    2. XM_039079404.1 → XP_038935332.1  NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial isoform X1

      UniProtKB/TrEMBL
      A0A8I6AES7
      Conserved Domains (1) summary
      PRK06411
      Location:76 → 226
      PRK06411; NADH-quinone oxidoreductase subunit NuoB

    3. XM_039079405.2 → XP_038935333.1  NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial isoform X3

      UniProtKB/TrEMBL
      A6K8N7
      Conserved Domains (1) summary
      PRK06411
      Location:1 → 132
      PRK06411; NADH-quinone oxidoreductase subunit NuoB
    Nucleotide Protein Strain
    Heading Accession and Version

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