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    KIF18B kinesin family member 18B [ Homo sapiens (human) ]

    Gene ID: 146909, updated on 10-Dec-2024

    Summary

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    Official Symbol
    KIF18Bprovided by HGNC
    Official Full Name
    kinesin family member 18Bprovided by HGNC
    Primary source
    HGNC:HGNC:27102
    See related
    Ensembl:ENSG00000186185 MIM:614570; AllianceGenome:HGNC:27102
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Enables cytoskeletal motor activity and kinesin binding activity. Involved in microtubule depolymerization; mitotic cell cycle; and regulation of cell division. Located in cytosol; microtubule; and nuclear body. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in bone marrow (RPKM 3.6), lymph node (RPKM 2.4) and 14 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See KIF18B in Genome Data Viewer
    Location:
    17q21.31
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (44924711..44947773, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (45778623..45801668, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (43002079..43025141, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene elongation factor Tu GTP binding domain containing 2 Neighboring gene RNA, 7SL, cytoplasmic 405, pseudogene Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr17:42969539-42970081 Neighboring gene dynein axonemal assembly factor 19 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12266 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8603 Neighboring gene family with sequence similarity 187 member A Neighboring gene glial fibrillary acidic protein Neighboring gene uncharacterized LOC105371793 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:42997401-42997900 Neighboring gene microRNA 6783 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12267 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:43025111-43025630 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:43031038-43031303 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:43039086-43039586 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8604 Neighboring gene basic proline-rich protein-like Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8605 Neighboring gene complement C1q like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Differential Expression of KIF18B in Gastric Cancer and Its Role in Chemotherapy Sensitivity. Gan LH, et al. Crit Rev Eukaryot Gene Expr, 2024. PMID 38305287
    2. Biased Brownian motion as a mechanism to facilitate nanometer-scale exploration of the microtubule plus end by a kinesin-8. Shin Y, et al. Proc Natl Acad Sci U S A, 2015 Jul 21. PMID 26150501, Free PMC Article
    3. Kinesin family member 18B: A contributor and facilitator in the proliferation and metastasis of cutaneous melanoma. Yan H, et al. J Biochem Mol Toxicol, 2019 Dec. PMID 31617652
    4. KIF18B as a regulator in microtubule movement accelerates tumor progression and triggers poor outcome in lung adenocarcinoma. Ji Z, et al. Tissue Cell, 2019 Dec. PMID 31759406
    5. Silencing KIF18B enhances radiosensitivity: identification of a promising therapeutic target in sarcoma. Liu W, et al. EBioMedicine, 2020 Nov. PMID 33038765, Free PMC Article

    See all (58) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Kinesin Family Member B18 Is Related to Gastric Mucin Phenotype and Contributes to Gastric Cancer Progression by Regulating Epithelial-Mesenchymal Transition.
      Title: Kinesin Family Member B18 Is Related to Gastric Mucin Phenotype and Contributes to Gastric Cancer Progression by Regulating Epithelial-Mesenchymal Transition.
    2. Differential Expression of KIF18B in Gastric Cancer and Its Role in Chemotherapy Sensitivity.
      Title: Differential Expression of KIF18B in Gastric Cancer and Its Role in Chemotherapy Sensitivity.
    3. Upregulation of KIF18B facilitates malignant phenotype of esophageal squamous cell carcinoma by activating CDCA8/mTORC1 pathway.
      Title: Upregulation of KIF18B facilitates malignant phenotype of esophageal squamous cell carcinoma by activating CDCA8/mTORC1 pathway.
    4. miR-139-3p/Kinesin family member 18B axis suppresses malignant progression of gastric cancer.
      Title: miR-139-3p/Kinesin family member 18B axis suppresses malignant progression of gastric cancer.
    5. Silencing of KIF18B restricts proliferation and invasion and enhances the chemosensitivity of breast cancer via modulating Akt/GSK-3beta/beta-catenin pathway.
      Title: Silencing of KIF18B restricts proliferation and invasion and enhances the chemosensitivity of breast cancer via modulating Akt/GSK-3β/β-catenin pathway.
    6. The nuclear kinesin KIF18B promotes 53BP1-mediated DNA double-strand break repair.
      Title: The nuclear kinesin KIF18B promotes 53BP1-mediated DNA double-strand break repair.
    7. KIF18b-dependent hypomethylation of PARPBP gene promoter enhances oxaliplatin resistance in colorectal cancer.
      Title: KIF18b-dependent hypomethylation of PARPBP gene promoter enhances oxaliplatin resistance in colorectal cancer.
    8. Kinesin family member 18B regulates the proliferation and invasion of human prostate cancer cells.
      Title: Kinesin family member 18B regulates the proliferation and invasion of human prostate cancer cells.
    9. KIF18B promotes tumor progression in osteosarcoma by activating beta-catenin.
      Title: KIF18B promotes tumor progression in osteosarcoma by activating β-catenin.
    10. KIF18B as a regulator in tumor microenvironment accelerates tumor progression and triggers poor outcome in hepatocellular carcinoma.
      Title: KIF18B as a regulator in tumor microenvironment accelerates tumor progression and triggers poor outcome in hepatocellular carcinoma.
    Submit: New GeneRIF Correction See all GeneRIFs (23)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cytoskeletal motor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables kinesin binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables plus-end-directed microtubule motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in microtubule depolymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule depolymerization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in microtubule-based movement IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic cell cycle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in mitotic sister chromatid segregation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cell division IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in astral microtubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    part_of kinesin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in microtubule end IDA
    Inferred from Direct Assay
    more info
    		  
    located_in microtubule plus-end IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mitotic spindle astral microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitotic spindle midzone IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear body IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    kinesin-like protein KIF18B

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001264573.2 → NP_001251503.1  kinesin-like protein KIF18B isoform 2

      See identical proteins and their annotated locations for NP_001251503.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has multiple differences in the coding region, compared to variant 1, one of which results in a frameshift. The resulting protein (isoform 2) has a distinct C-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC015936, BC067365, BC144271, BX405609
      Consensus CDS
      CCDS58555.1
      UniProtKB/TrEMBL
      A0A494BYR6
      Related
      ENSP00000465377.1, ENST00000587309.5
      Conserved Domains (2) summary
      smart00129
      Location:9 → 358
      KISc; Kinesin motor, catalytic domain. ATPase
      cd01370
      Location:7 → 351
      KISc_KIP3_like; Kinesin motor domain, KIP3-like subgroup

    2. NM_001265577.2 → NP_001252506.1  kinesin-like protein KIF18B isoform 1

      See identical proteins and their annotated locations for NP_001252506.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC015936, BC067365, BC136590, BX405609
      Consensus CDS
      CCDS45709.2
      UniProtKB/Swiss-Prot
      A0A0C4DGP2, A0A0C4DGP5, A6NJI2, B7ZM49, B9EGM8, D5L6I1, Q86Y91
      UniProtKB/TrEMBL
      A0A494BYR6
      Related
      ENSP00000465992.1, ENST00000593135.6
      Conserved Domains (2) summary
      PHA03247
      Location:585 → 824
      PHA03247; large tegument protein UL36; Provisional
      cd01370
      Location:7 → 351
      KISc_KIP3_like; Kinesin motor domain, KIP3-like subgroup

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      44924711..44947773 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011524386.3 → XP_011522688.1  kinesin-like protein KIF18B isoform X3

      UniProtKB/TrEMBL
      A0A494BYR6
      Conserved Domains (2) summary
      smart00129
      Location:9 → 358
      KISc; Kinesin motor, catalytic domain. ATPase
      cd01370
      Location:7 → 351
      KISc_KIP3_like; Kinesin motor domain, KIP3-like subgroup

    2. XM_047435469.1 → XP_047291425.1  kinesin-like protein KIF18B isoform X7

      UniProtKB/TrEMBL
      A0A494BYR6

    3. XM_011524387.3 → XP_011522689.1  kinesin-like protein KIF18B isoform X2

      UniProtKB/TrEMBL
      A0A494BYR6
      Conserved Domains (2) summary
      smart00129
      Location:18 → 367
      KISc; Kinesin motor, catalytic domain. ATPase
      cd01370
      Location:16 → 360
      KISc_KIP3_like; Kinesin motor domain, KIP3-like subgroup

    4. XM_011524385.3 → XP_011522687.1  kinesin-like protein KIF18B isoform X1

      UniProtKB/TrEMBL
      A0A494BYR6
      Conserved Domains (2) summary
      smart00129
      Location:18 → 367
      KISc; Kinesin motor, catalytic domain. ATPase
      cd01370
      Location:16 → 360
      KISc_KIP3_like; Kinesin motor domain, KIP3-like subgroup

    5. XM_011524389.3 → XP_011522691.1  kinesin-like protein KIF18B isoform X5

      UniProtKB/TrEMBL
      A0A494BYR6
      Conserved Domains (2) summary
      smart00129
      Location:18 → 367
      KISc; Kinesin motor, catalytic domain. ATPase
      cd01370
      Location:16 → 360
      KISc_KIP3_like; Kinesin motor domain, KIP3-like subgroup

    6. XM_011524390.2 → XP_011522692.1  kinesin-like protein KIF18B isoform X6

      UniProtKB/TrEMBL
      A0A494BYR6
      Conserved Domains (2) summary
      smart00129
      Location:18 → 332
      KISc; Kinesin motor, catalytic domain. ATPase
      cl22853
      Location:16 → 325
      Motor_domain; Myosin and Kinesin motor domain

    7. XM_011524388.3 → XP_011522690.1  kinesin-like protein KIF18B isoform X4

      UniProtKB/TrEMBL
      A0A494BYR6
      Conserved Domains (2) summary
      smart00129
      Location:18 → 367
      KISc; Kinesin motor, catalytic domain. ATPase
      cd01370
      Location:16 → 360
      KISc_KIP3_like; Kinesin motor domain, KIP3-like subgroup

    8. XM_011524391.4 → XP_011522693.1  kinesin-like protein KIF18B isoform X8

      Conserved Domains (2) summary
      smart00129
      Location:18 → 367
      KISc; Kinesin motor, catalytic domain. ATPase
      cd01370
      Location:16 → 360
      KISc_KIP3_like; Kinesin motor domain, KIP3-like subgroup

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      45778623..45801668 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054315216.1 → XP_054171191.1  kinesin-like protein KIF18B isoform X3

      UniProtKB/TrEMBL
      A0A494BYR6

    2. XM_054315215.1 → XP_054171190.1  kinesin-like protein KIF18B isoform X2

      UniProtKB/TrEMBL
      A0A494BYR6

    3. XM_054315218.1 → XP_054171193.1  kinesin-like protein KIF18B isoform X5

      UniProtKB/TrEMBL
      A0A494BYR6

    4. XM_054315214.1 → XP_054171189.1  kinesin-like protein KIF18B isoform X1

      UniProtKB/TrEMBL
      A0A494BYR6

    5. XM_054315220.1 → XP_054171195.1  kinesin-like protein KIF18B isoform X7

      UniProtKB/TrEMBL
      A0A494BYR6

    6. XM_054315219.1 → XP_054171194.1  kinesin-like protein KIF18B isoform X6

      UniProtKB/TrEMBL
      A0A494BYR6

    7. XM_054315217.1 → XP_054171192.1  kinesin-like protein KIF18B isoform X4

      UniProtKB/TrEMBL
      A0A494BYR6

    8. XM_054315221.1 → XP_054171196.1  kinesin-like protein KIF18B isoform X8

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001080443.1: Suppressed sequence

      Description
      NM_001080443.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q86Y91.4 GenPept UniProtKB/Swiss-Prot:Q86Y91

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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