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    CFAP210 cilia and flagella associated protein 210 [ Homo sapiens (human) ]

    Gene ID: 129881, updated on 27-Nov-2024

    Summary

    Official Symbol
    CFAP210provided by HGNC
    Official Full Name
    cilia and flagella associated protein 210provided by HGNC
    Primary source
    HGNC:HGNC:25064
    See related
    Ensembl:ENSG00000154479 AllianceGenome:HGNC:25064
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C2orf77; CCDC173
    Summary
    Predicted to be involved in flagellated sperm motility. Located in axonemal microtubule. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward testis (RPKM 36.5) See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See CFAP210 in Genome Data Viewer
    Location:
    2q31.1
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (169645425..169694405, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (170122581..170174007, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (170501935..170550915, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ReSE screen-validated silencer GRCh37_chr2:170393950-170394098 Neighboring gene FAST kinase domains 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:170429982-170430584 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16741 Neighboring gene peptidylprolyl isomerase G Neighboring gene MPRA-validated peak3919 silencer Neighboring gene CYFIP related Rac1 interactor B pseudogene Neighboring gene PHOSPHO2-KLHL23 readthrough Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16742 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12082 Neighboring gene phosphatase, orphan 2 Neighboring gene uncharacterized LOC124906089

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in flagellated sperm motility ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    is_active_in axonemal B tubule inner sheath ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in axonemal microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in axonemal microtubule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in axonemal microtubule ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in sperm flagellum ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    cilia- and flagella- associated protein 210
    Names
    coiled-coil domain containing 173
    coiled-coil domain-containing protein 173
    protein CFAP210

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001085447.2NP_001078916.1  cilia- and flagella- associated protein 210

      See identical proteins and their annotated locations for NP_001078916.1

      Status: VALIDATED

      Source sequence(s)
      AC016772, BC117445, BQ432665, CB250451
      Consensus CDS
      CCDS46445.1
      UniProtKB/Swiss-Prot
      Q0VFZ6, Q6PJF6
      UniProtKB/TrEMBL
      B4DX81
      Related
      ENSP00000391504.1, ENST00000447353.6
      Conserved Domains (1) summary
      pfam13868
      Location:148480
      TPH; Trichohyalin-plectin-homology domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      169645425..169694405 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047443327.1XP_047299283.1  cilia- and flagella- associated protein 210 isoform X3

    2. XM_011510590.2XP_011508892.1  cilia- and flagella- associated protein 210 isoform X2

      Conserved Domains (1) summary
      pfam13868
      Location:67399
      TPH; Trichohyalin-plectin-homology domain
    3. XM_047443326.1XP_047299282.1  cilia- and flagella- associated protein 210 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      170122581..170174007 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054340497.1XP_054196472.1  cilia- and flagella- associated protein 210 isoform X3

    2. XM_054340496.1XP_054196471.1  cilia- and flagella- associated protein 210 isoform X2

    3. XM_054340495.1XP_054196470.1  cilia- and flagella- associated protein 210 isoform X1