Cask calcium/calmodulin dependent serine protein kinase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Caskprovided by MGI
Official Full Name: calcium/calmodulin dependent serine protein kinaseprovided by MGI
Primary source: MGI:MGI:1309489
See related: Ensembl:ENSMUSG00000031012 AllianceGenome:MGI:1309489
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: LIN-2; Pals3; DXPri1; DXRib1; mLin-2
Summary: Enables neurexin family protein binding activity. Involved in regulation of synaptic vesicle exocytosis. Acts upstream of or within several processes, including calcium ion import; positive regulation of calcium ion import; and positive regulation of transcription by RNA polymerase II. Located in several cellular components, including basolateral plasma membrane; cell-cell junction; and cytosol. Is active in Schaffer collateral - CA1 synapse. Colocalizes with basement membrane. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in FG syndrome and syndromic X-linked intellectual disability Najm type. Orthologous to human CASK (calcium/calmodulin dependent serine protein kinase). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in CNS E18 (RPKM 10.1), whole brain E14.5 (RPKM 9.1) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: X A1.1; X 8.43 cM

Exon count:: 28

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (13383319..13713020, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (13517080..13846783, complement)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Genetic evidence for splicing-dependent structural and functional plasticity in CASK protein.
Title: Genetic evidence for splicing-dependent structural and functional plasticity in CASK protein.
Loss of CASK Accelerates Heart Failure Development.
Title: Loss of CASK Accelerates Heart Failure Development.
Haploinsufficiency of X-linked intellectual disability gene CASK induces post-transcriptional changes in synaptic and cellular metabolic pathways.
Title: Haploinsufficiency of X-linked intellectual disability gene CASK induces post-transcriptional changes in synaptic and cellular metabolic pathways.
CASK can induce the recurrence of Focal and Segmental GlomeruloSclerosis after renal transplantation.
Title: Circulating CASK is associated with recurrent focal segmental glomerulosclerosis after transplantation.
Authors ascertain that a large fraction of endogenous CNTNAP2, CASK, and GluA1 molecules collectively colocalize together in a tripartite manner. Individual knockdown of either CNTNAP2 or CASK similarly alter GluA1 levels and localization. These findings offer insight to molecular mechanisms underlying GluA1 regulation in interneurons.
Title: The CNTNAP2-CASK complex modulates GluA1 subcellular distribution in interneurons.
Our results demonstrate that mosaic or global reduction in CASK expression and/or function disproportionately affects retinal ganglion cells (RGCs). CASK expression in RGCs does not appear critical for cell survival, indicating a noncell autonomous role for CASK in the development of optic nerve.
Title: Non-Cell Autonomous Roles for CASK in Optic Nerve Hypoplasia.
CASK T740A mutation attenuated the interaction between CASK and TBR1 in the brain. However, CASK T740A mice were generally healthy, without obvious defects in brain morphology. The most dramatic defect among the mutant mice was in extinction of associative memory, though acquisition was normal.
Title: Calcium/calmodulin-dependent serine protein kinase (CASK), a protein implicated in mental retardation and autism-spectrum disorders, interacts with T-Brain-1 (TBR1) to control extinction of associative memory in male mice.
CASK phosphorylates neurexin, modulating the interaction of liprin-alpha with the CASK-neurexin1beta-Mint1 complex.
Title: CASK stabilizes neurexin and links it to liprin-α in a neuronal activity-dependent manner.
Ths data of this study implies that some phenotypic components of CASK heterozygous deletion mutation associated disorders represent systemic manifestation of metabolic stress.
Title: X-linked intellectual disability gene CASK regulates postnatal brain growth in a non-cell autonomous manner.
The findings suggest that CASK and the truncated prestin splice isoform contribute to confinement of prestin to the basolateral region of the plasma membrane.
Title: Generation of somatic electromechanical force by outer hair cells may be influenced by prestin-CASK interaction at the basal junction with the Deiter's cell.

Submit: New GeneRIF Correction See all GeneRIFs (25)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (3) 1 citation
Transgenic (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Gpr82 (e-PCR), detects polymorphism
- UniSTS:527368

px-14e7 (e-PCR)
- UniSTS:257290

px-63h9 (e-PCR)
- UniSTS:258084

px-46a8 (e-PCR)
- UniSTS:257840

G49441 (e-PCR)
- UniSTS:109184

px-63e10 (e-PCR)
- UniSTS:258442

Cask (e-PCR), detects polymorphism
- UniSTS:256655

Cask (e-PCR), detects polymorphism
- UniSTS:527276

Cask (e-PCR), detects polymorphism
- UniSTS:256961

Cask (e-PCR), detects polymorphism
- UniSTS:256962

Cask (e-PCR), detects polymorphism
- UniSTS:256963

Cask (e-PCR), detects polymorphism
- UniSTS:256964

px-3c2 (e-PCR)
- UniSTS:257732

UniSTS:256965 (e-PCR)
- UniSTS:256965

Cask (e-PCR), detects polymorphism
- UniSTS:256965

Cask (e-PCR), detects polymorphism
- UniSTS:256966

px-26a4 (e-PCR)
- UniSTS:257481

px-59g5 (e-PCR)
- UniSTS:257993

Cask (e-PCR), detects polymorphism
- UniSTS:548054

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 3-phosphoinositide-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables PDZ domain binding	ISO Inferred from Sequence Orthology more info
enables Rho-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables calmodulin binding	IEA Inferred from Electronic Annotation more info
enables eukaryotic translation initiation factor 2alpha kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS121 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AT120 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS139 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS14 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS36 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S28 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S57 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T11 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T3 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T45 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T6 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H4S1 kinase activity	IEA Inferred from Electronic Annotation more info
enables neurexin family protein binding	IDA Inferred from Direct Assay more info	PubMed
enables neurexin family protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase C binding	ISO Inferred from Sequence Orthology more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables ribosomal protein S6 kinase activity	IEA Inferred from Electronic Annotation more info
enables signaling receptor binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within calcium ion import	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within establishment of localization in cell	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell-matrix adhesion	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell-matrix adhesion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cellular response to growth factor stimulus	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cellular response to growth factor stimulus	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of keratinocyte proliferation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of keratinocyte proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of wound healing	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of wound healing	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of calcium ion import	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of dendritic spine morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of insulin secretion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein localization	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in regulation of neurotransmitter secretion	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of synaptic vesicle exocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of synaptic vesicle exocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in Schaffer collateral - CA1 synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in Schaffer collateral - CA1 synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in apical dendrite	ISO Inferred from Sequence Orthology more info
colocalizes_with basement membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basement membrane	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with basement membrane	ISO Inferred from Sequence Orthology more info
located_in basement membrane	ISO Inferred from Sequence Orthology more info
is_active_in basolateral plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in cell-cell junction	IBA Inferred from Biological aspect of Ancestor more info
located_in cell-cell junction	IDA Inferred from Direct Assay more info	PubMed
located_in cell-cell junction	ISO Inferred from Sequence Orthology more info
located_in ciliary membrane	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in nuclear lamina	IEA Inferred from Electronic Annotation more info
located_in nuclear lamina	ISO Inferred from Sequence Orthology more info
located_in nuclear matrix	IEA Inferred from Electronic Annotation more info
located_in nuclear matrix	ISO Inferred from Sequence Orthology more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in podocyte foot	ISO Inferred from Sequence Orthology more info
located_in presynaptic membrane	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
located_in synapse	IDA Inferred from Direct Assay more info	PubMed
located_in synaptic membrane	ISO Inferred from Sequence Orthology more info
located_in vesicle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: peripheral plasma membrane protein CASK

Names: calcium/calmodulin-dependent serine protein kinase (MAGUK family)

NP_001271432.1

EC 2.7.11.1

NP_001271433.1

EC 2.7.11.1

NP_001271434.1

EC 2.7.11.1

NP_033936.2

EC 2.7.11.1

XP_006527623.1

EC 2.7.11.1

XP_006527624.1

EC 2.7.11.1

XP_011245733.1

EC 2.7.11.1

XP_011245734.1

EC 2.7.11.1

XP_011245735.1

EC 2.7.11.1

XP_011245736.1

EC 2.7.11.1

XP_011245737.1

EC 2.7.11.1

XP_011245738.1

EC 2.7.11.1

XP_011245739.1

EC 2.7.11.1

XP_011245740.1

EC 2.7.11.1

XP_011245741.1

EC 2.7.11.1

XP_011245742.1

EC 2.7.11.1

XP_011245743.1

EC 2.7.11.1

XP_017173855.1

EC 2.7.11.1

XP_017173856.1

EC 2.7.11.1

XP_017173857.1

EC 2.7.11.1

XP_017173858.1

EC 2.7.11.1

XP_017173859.1

EC 2.7.11.1

XP_017173860.1

EC 2.7.11.1

XP_036017689.1

EC 2.7.11.1

XP_036017690.1

EC 2.7.11.1

XP_036017691.1

EC 2.7.11.1

XP_036017692.1

EC 2.7.11.1

XP_036017693.1

EC 2.7.11.1

XP_036017694.1

EC 2.7.11.1

XP_036017695.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001284503.1 → NP_001271432.1 peripheral plasma membrane protein CASK isoform 1

See identical proteins and their annotated locations for NP_001271432.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest protein (isoform 1).

Source sequence(s)

AK136523, AL671117, BU700766, CJ060796, CJ317104, Y17138

UniProtKB/Swiss-Prot

A2ADP8, A2ADP9, A2ADQ4, O70588, O70589, Q3UW92

UniProtKB/TrEMBL

B7ZP42

Conserved Domains (6) summary

smart00569
Location:348 → 401

L27; domain in receptor targeting proteins Lin-2 and Lin-7

cd12081
Location:616 → 677

SH3_CASK; Src Homology 3 domain of Calcium/calmodulin-dependent Serine protein Kinase

cd00992
Location:488 → 568

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd14094
Location:8 → 307

STKc_CASK; Catalytic domain of the Serine/Threonine Kinase, Calcium/calmodulin-dependent serine protein kinase

pfam00625
Location:738 → 911

Guanylate_kin; Guanylate kinase

pfam02828
Location:406 → 456

L27; L27 domain
NM_001284504.1 → NP_001271433.1 peripheral plasma membrane protein CASK isoform 2

See identical proteins and their annotated locations for NP_001271433.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) has multiple in-frame differences in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.

Source sequence(s)

AK136523, AL671117, BU700766, CJ060796, CJ317104, Y17138

UniProtKB/TrEMBL

B7ZP42, B9EJ23

Conserved Domains (6) summary

smart00569
Location:342 → 395

L27; domain in receptor targeting proteins Lin-2 and Lin-7

cd12081
Location:575 → 636

SH3_CASK; Src Homology 3 domain of Calcium/calmodulin-dependent Serine protein Kinase

cd00992
Location:482 → 562

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd14094
Location:8 → 307

STKc_CASK; Catalytic domain of the Serine/Threonine Kinase, Calcium/calmodulin-dependent serine protein kinase

pfam00625
Location:692 → 865

Guanylate_kin; Guanylate kinase

pfam02828
Location:400 → 450

L27; L27 domain
NM_001284505.1 → NP_001271434.1 peripheral plasma membrane protein CASK isoform 3

See identical proteins and their annotated locations for NP_001271434.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1.

Source sequence(s)

AK136523, AL671117, BU700766, CJ060796, CJ317104, Y17138

Consensus CDS

CCDS72343.1

UniProtKB/TrEMBL

B7ZP42

Related

ENSMUSP00000111098.4, ENSMUST00000115438.10

Conserved Domains (6) summary

smart00569
Location:342 → 395

L27; domain in receptor targeting proteins Lin-2 and Lin-7

cd12081
Location:610 → 671

SH3_CASK; Src Homology 3 domain of Calcium/calmodulin-dependent Serine protein Kinase

cd00992
Location:482 → 562

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd14094
Location:8 → 307

STKc_CASK; Catalytic domain of the Serine/Threonine Kinase, Calcium/calmodulin-dependent serine protein kinase

pfam00625
Location:732 → 905

Guanylate_kin; Guanylate kinase

pfam02828
Location:400 → 450

L27; L27 domain
NM_009806.3 → NP_033936.2 peripheral plasma membrane protein CASK isoform 4

See identical proteins and their annotated locations for NP_033936.2

Status: VALIDATED

Description

Transcript Variant: This variant (4) lacks several alternate in-frame exons in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 4), compared to isoform 1.

Source sequence(s)

AK136523, AL671117, BU700766, CJ060796, CJ317104, Y17138

Consensus CDS

CCDS40878.1

UniProtKB/TrEMBL

B7ZP42

Related

ENSMUSP00000111096.3, ENSMUST00000115436.9

Conserved Domains (6) summary

smart00569
Location:342 → 395

L27; domain in receptor targeting proteins Lin-2 and Lin-7

cd12081
Location:587 → 648

SH3_CASK; Src Homology 3 domain of Calcium/calmodulin-dependent Serine protein Kinase

cd00992
Location:482 → 562

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd14094
Location:8 → 307

STKc_CASK; Catalytic domain of the Serine/Threonine Kinase, Calcium/calmodulin-dependent serine protein kinase

pfam00625
Location:709 → 882

Guanylate_kin; Guanylate kinase

pfam02828
Location:400 → 450

L27; L27 domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000086.8 Reference GRCm39 C57BL/6J

Range

13383319..13713020 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011247437.3 → XP_011245739.1 peripheral plasma membrane protein CASK isoform X12

UniProtKB/TrEMBL

B7ZP42

Conserved Domains (6) summary

smart00569
Location:354 → 407

L27; domain in receptor targeting proteins Lin-2 and Lin-7

cd12081
Location:587 → 648

SH3_CASK; Src Homology 3 domain of Calcium/calmodulin-dependent Serine protein Kinase

cd00992
Location:494 → 574

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd14094
Location:8 → 313

STKc_CASK; Catalytic domain of the Serine/Threonine Kinase, Calcium/calmodulin-dependent serine protein kinase

pfam00625
Location:709 → 922

Guanylate_kin; Guanylate kinase

pfam02828
Location:412 → 462

L27; L27 domain
XM_036161798.1 → XP_036017691.1 peripheral plasma membrane protein CASK isoform X9

UniProtKB/TrEMBL

B7ZP42

Conserved Domains (6) summary

smart00569
Location:354 → 407

L27; domain in receptor targeting proteins Lin-2 and Lin-7

cd12081
Location:599 → 660

SH3_CASK; Src Homology 3 domain of Calcium/calmodulin-dependent Serine protein Kinase

cd00992
Location:494 → 574

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd14094
Location:8 → 313

STKc_CASK; Catalytic domain of the Serine/Threonine Kinase, Calcium/calmodulin-dependent serine protein kinase

pfam00625
Location:716 → 929

Guanylate_kin; Guanylate kinase

pfam02828
Location:412 → 462

L27; L27 domain
XM_011247436.4 → XP_011245738.1 peripheral plasma membrane protein CASK isoform X8

UniProtKB/TrEMBL

B7ZP42

Conserved Domains (6) summary

smart00569
Location:354 → 407

L27; domain in receptor targeting proteins Lin-2 and Lin-7

cd12081
Location:599 → 660

SH3_CASK; Src Homology 3 domain of Calcium/calmodulin-dependent Serine protein Kinase

cd00992
Location:494 → 574

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd14094
Location:8 → 313

STKc_CASK; Catalytic domain of the Serine/Threonine Kinase, Calcium/calmodulin-dependent serine protein kinase

pfam00625
Location:721 → 934

Guanylate_kin; Guanylate kinase

pfam02828
Location:412 → 462

L27; L27 domain
XM_036161797.1 → XP_036017690.1 peripheral plasma membrane protein CASK isoform X7

UniProtKB/TrEMBL

B7ZP42

Conserved Domains (6) summary

smart00569
Location:354 → 407

L27; domain in receptor targeting proteins Lin-2 and Lin-7

cd12081
Location:610 → 671

SH3_CASK; Src Homology 3 domain of Calcium/calmodulin-dependent Serine protein Kinase

cd00992
Location:494 → 574

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd14094
Location:8 → 313

STKc_CASK; Catalytic domain of the Serine/Threonine Kinase, Calcium/calmodulin-dependent serine protein kinase

pfam00625
Location:727 → 940

Guanylate_kin; Guanylate kinase

pfam02828
Location:412 → 462

L27; L27 domain
XM_011247435.4 → XP_011245737.1 peripheral plasma membrane protein CASK isoform X6

UniProtKB/TrEMBL

B7ZP42

Conserved Domains (6) summary

smart00569
Location:354 → 407

L27; domain in receptor targeting proteins Lin-2 and Lin-7

cd12081
Location:610 → 671

SH3_CASK; Src Homology 3 domain of Calcium/calmodulin-dependent Serine protein Kinase

cd00992
Location:494 → 574

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd14094
Location:8 → 313

STKc_CASK; Catalytic domain of the Serine/Threonine Kinase, Calcium/calmodulin-dependent serine protein kinase

pfam00625
Location:732 → 945

Guanylate_kin; Guanylate kinase

pfam02828
Location:412 → 462

L27; L27 domain
XM_011247432.3 → XP_011245734.1 peripheral plasma membrane protein CASK isoform X2

UniProtKB/TrEMBL

B7ZP42

Conserved Domains (6) summary

smart00569
Location:354 → 407

L27; domain in receptor targeting proteins Lin-2 and Lin-7

cd12081
Location:622 → 683

SH3_CASK; Src Homology 3 domain of Calcium/calmodulin-dependent Serine protein Kinase

cd00992
Location:494 → 574

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd14094
Location:8 → 313

STKc_CASK; Catalytic domain of the Serine/Threonine Kinase, Calcium/calmodulin-dependent serine protein kinase

pfam00625
Location:739 → 952

Guanylate_kin; Guanylate kinase

pfam02828
Location:412 → 462

L27; L27 domain
XM_036161799.1 → XP_036017692.1 peripheral plasma membrane protein CASK isoform X11

UniProtKB/TrEMBL

B7ZP42

Conserved Domains (6) summary

smart00569
Location:342 → 395

L27; domain in receptor targeting proteins Lin-2 and Lin-7

cd12081
Location:587 → 648

SH3_CASK; Src Homology 3 domain of Calcium/calmodulin-dependent Serine protein Kinase

cd00992
Location:482 → 562

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd14094
Location:8 → 307

STKc_CASK; Catalytic domain of the Serine/Threonine Kinase, Calcium/calmodulin-dependent serine protein kinase

pfam00625
Location:709 → 922

Guanylate_kin; Guanylate kinase

pfam02828
Location:400 → 450

L27; L27 domain
XM_036161796.1 → XP_036017689.1 peripheral plasma membrane protein CASK isoform X5

UniProtKB/TrEMBL

B7ZP42

Conserved Domains (6) summary

smart00569
Location:342 → 395

L27; domain in receptor targeting proteins Lin-2 and Lin-7

cd12081
Location:610 → 671

SH3_CASK; Src Homology 3 domain of Calcium/calmodulin-dependent Serine protein Kinase

cd00992
Location:482 → 562

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd14094
Location:8 → 307

STKc_CASK; Catalytic domain of the Serine/Threonine Kinase, Calcium/calmodulin-dependent serine protein kinase

pfam00625
Location:732 → 945

Guanylate_kin; Guanylate kinase

pfam02828
Location:400 → 450

L27; L27 domain
XM_011247440.4 → XP_011245742.1 peripheral plasma membrane protein CASK isoform X21

See identical proteins and their annotated locations for XP_011245742.1

UniProtKB/TrEMBL

B7ZP42

Conserved Domains (6) summary

smart00569
Location:348 → 401

L27; domain in receptor targeting proteins Lin-2 and Lin-7

cd12081
Location:604 → 665

SH3_CASK; Src Homology 3 domain of Calcium/calmodulin-dependent Serine protein Kinase

cd00992
Location:488 → 568

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd14094
Location:8 → 307

STKc_CASK; Catalytic domain of the Serine/Threonine Kinase, Calcium/calmodulin-dependent serine protein kinase

pfam00625
Location:721 → 894

Guanylate_kin; Guanylate kinase

pfam02828
Location:406 → 456

L27; L27 domain
XM_011247433.3 → XP_011245735.1 peripheral plasma membrane protein CASK isoform X3

UniProtKB/TrEMBL

B7ZP42

Conserved Domains (6) summary

smart00569
Location:348 → 401

L27; domain in receptor targeting proteins Lin-2 and Lin-7

cd12081
Location:616 → 677

SH3_CASK; Src Homology 3 domain of Calcium/calmodulin-dependent Serine protein Kinase

cd00992
Location:488 → 568

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd14094
Location:8 → 307

STKc_CASK; Catalytic domain of the Serine/Threonine Kinase, Calcium/calmodulin-dependent serine protein kinase

pfam00625
Location:738 → 951

Guanylate_kin; Guanylate kinase

pfam02828
Location:406 → 456

L27; L27 domain
XM_017318366.3 → XP_017173855.1 peripheral plasma membrane protein CASK isoform X10

UniProtKB/TrEMBL

B7ZP42

Conserved Domains (6) summary

smart00569
Location:348 → 401

L27; domain in receptor targeting proteins Lin-2 and Lin-7

cd12081
Location:593 → 654

SH3_CASK; Src Homology 3 domain of Calcium/calmodulin-dependent Serine protein Kinase

cd00992
Location:488 → 568

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd14094
Location:8 → 313

STKc_CASK; Catalytic domain of the Serine/Threonine Kinase, Calcium/calmodulin-dependent serine protein kinase

pfam00625
Location:715 → 928

Guanylate_kin; Guanylate kinase

pfam02828
Location:406 → 456

L27; L27 domain
XM_011247434.3 → XP_011245736.1 peripheral plasma membrane protein CASK isoform X4

UniProtKB/TrEMBL

B7ZP42

Conserved Domains (6) summary

smart00569
Location:348 → 401

L27; domain in receptor targeting proteins Lin-2 and Lin-7

cd12081
Location:616 → 677

SH3_CASK; Src Homology 3 domain of Calcium/calmodulin-dependent Serine protein Kinase

cd00992
Location:488 → 568

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd14094
Location:8 → 313

STKc_CASK; Catalytic domain of the Serine/Threonine Kinase, Calcium/calmodulin-dependent serine protein kinase

pfam00625
Location:738 → 951

Guanylate_kin; Guanylate kinase

pfam02828
Location:406 → 456

L27; L27 domain
XM_036161802.1 → XP_036017695.1 peripheral plasma membrane protein CASK isoform X26

UniProtKB/TrEMBL

B7ZP42

Conserved Domains (6) summary

smart00569
Location:354 → 407

L27; domain in receptor targeting proteins Lin-2 and Lin-7

cd12081
Location:587 → 648

SH3_CASK; Src Homology 3 domain of Calcium/calmodulin-dependent Serine protein Kinase

cd00992
Location:494 → 574

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd14094
Location:8 → 313

STKc_CASK; Catalytic domain of the Serine/Threonine Kinase, Calcium/calmodulin-dependent serine protein kinase

pfam00625
Location:704 → 877

Guanylate_kin; Guanylate kinase

pfam02828
Location:412 → 462

L27; L27 domain
XM_017318371.3 → XP_017173860.1 peripheral plasma membrane protein CASK isoform X25

UniProtKB/TrEMBL

B7ZP42

Conserved Domains (6) summary

smart00569
Location:354 → 407

L27; domain in receptor targeting proteins Lin-2 and Lin-7

cd12081
Location:587 → 648

SH3_CASK; Src Homology 3 domain of Calcium/calmodulin-dependent Serine protein Kinase

cd00992
Location:494 → 574

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd14094
Location:8 → 313

STKc_CASK; Catalytic domain of the Serine/Threonine Kinase, Calcium/calmodulin-dependent serine protein kinase

pfam00625
Location:709 → 882

Guanylate_kin; Guanylate kinase

pfam02828
Location:412 → 462

L27; L27 domain
XM_017318370.3 → XP_017173859.1 peripheral plasma membrane protein CASK isoform X22

UniProtKB/TrEMBL

B7ZP42

Conserved Domains (6) summary

smart00569
Location:354 → 407

L27; domain in receptor targeting proteins Lin-2 and Lin-7

cd12081
Location:599 → 660

SH3_CASK; Src Homology 3 domain of Calcium/calmodulin-dependent Serine protein Kinase

cd00992
Location:494 → 574

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd14094
Location:8 → 313

STKc_CASK; Catalytic domain of the Serine/Threonine Kinase, Calcium/calmodulin-dependent serine protein kinase

pfam00625
Location:716 → 889

Guanylate_kin; Guanylate kinase

pfam02828
Location:412 → 462

L27; L27 domain
XM_017318369.3 → XP_017173858.1 peripheral plasma membrane protein CASK isoform X20

UniProtKB/TrEMBL

B7ZP42

Conserved Domains (6) summary

smart00569
Location:354 → 407

L27; domain in receptor targeting proteins Lin-2 and Lin-7

cd12081
Location:599 → 660

SH3_CASK; Src Homology 3 domain of Calcium/calmodulin-dependent Serine protein Kinase

cd00992
Location:494 → 574

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd14094
Location:8 → 313

STKc_CASK; Catalytic domain of the Serine/Threonine Kinase, Calcium/calmodulin-dependent serine protein kinase

pfam00625
Location:721 → 894

Guanylate_kin; Guanylate kinase

pfam02828
Location:412 → 462

L27; L27 domain
XM_017318368.3 → XP_017173857.1 peripheral plasma membrane protein CASK isoform X19

UniProtKB/TrEMBL

B7ZP42

Conserved Domains (6) summary

smart00569
Location:354 → 407

L27; domain in receptor targeting proteins Lin-2 and Lin-7

cd12081
Location:610 → 671

SH3_CASK; Src Homology 3 domain of Calcium/calmodulin-dependent Serine protein Kinase

cd00992
Location:494 → 574

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd14094
Location:8 → 313

STKc_CASK; Catalytic domain of the Serine/Threonine Kinase, Calcium/calmodulin-dependent serine protein kinase

pfam00625
Location:727 → 900

Guanylate_kin; Guanylate kinase

pfam02828
Location:412 → 462

L27; L27 domain
XM_011247439.4 → XP_011245741.1 peripheral plasma membrane protein CASK isoform X18

UniProtKB/TrEMBL

B7ZP42

Conserved Domains (6) summary

smart00569
Location:354 → 407

L27; domain in receptor targeting proteins Lin-2 and Lin-7

cd12081
Location:610 → 671

SH3_CASK; Src Homology 3 domain of Calcium/calmodulin-dependent Serine protein Kinase

cd00992
Location:494 → 574

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd14094
Location:8 → 313

STKc_CASK; Catalytic domain of the Serine/Threonine Kinase, Calcium/calmodulin-dependent serine protein kinase

pfam00625
Location:732 → 905

Guanylate_kin; Guanylate kinase

pfam02828
Location:412 → 462

L27; L27 domain
XM_017318367.3 → XP_017173856.1 peripheral plasma membrane protein CASK isoform X14

UniProtKB/TrEMBL

B7ZP42

Conserved Domains (6) summary

smart00569
Location:354 → 407

L27; domain in receptor targeting proteins Lin-2 and Lin-7

cd12081
Location:622 → 683

SH3_CASK; Src Homology 3 domain of Calcium/calmodulin-dependent Serine protein Kinase

cd00992
Location:494 → 574

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd14094
Location:8 → 313

STKc_CASK; Catalytic domain of the Serine/Threonine Kinase, Calcium/calmodulin-dependent serine protein kinase

pfam00625
Location:739 → 912

Guanylate_kin; Guanylate kinase

pfam02828
Location:412 → 462

L27; L27 domain
XM_011247431.3 → XP_011245733.1 peripheral plasma membrane protein CASK isoform X1

UniProtKB/TrEMBL

B7ZP42

Conserved Domains (6) summary

smart00569
Location:354 → 407

L27; domain in receptor targeting proteins Lin-2 and Lin-7

cd12081
Location:622 → 683

SH3_CASK; Src Homology 3 domain of Calcium/calmodulin-dependent Serine protein Kinase

cd00992
Location:494 → 574

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd14094
Location:8 → 313

STKc_CASK; Catalytic domain of the Serine/Threonine Kinase, Calcium/calmodulin-dependent serine protein kinase

pfam00625
Location:744 → 957

Guanylate_kin; Guanylate kinase

pfam02828
Location:412 → 462

L27; L27 domain
XM_006527561.5 → XP_006527624.1 peripheral plasma membrane protein CASK isoform X24

See identical proteins and their annotated locations for XP_006527624.1

UniProtKB/TrEMBL

B7ZP42

Conserved Domains (6) summary

smart00569
Location:348 → 401

L27; domain in receptor targeting proteins Lin-2 and Lin-7

cd12081
Location:593 → 654

SH3_CASK; Src Homology 3 domain of Calcium/calmodulin-dependent Serine protein Kinase

cd00992
Location:488 → 568

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd14094
Location:8 → 307

STKc_CASK; Catalytic domain of the Serine/Threonine Kinase, Calcium/calmodulin-dependent serine protein kinase

pfam00625
Location:710 → 883

Guanylate_kin; Guanylate kinase

pfam02828
Location:406 → 456

L27; L27 domain
XM_006527560.5 → XP_006527623.1 peripheral plasma membrane protein CASK isoform X16

See identical proteins and their annotated locations for XP_006527623.1

UniProtKB/TrEMBL

B7ZP42

Conserved Domains (6) summary

smart00569
Location:348 → 401

L27; domain in receptor targeting proteins Lin-2 and Lin-7

cd12081
Location:616 → 677

SH3_CASK; Src Homology 3 domain of Calcium/calmodulin-dependent Serine protein Kinase

cd00992
Location:488 → 568

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd14094
Location:8 → 307

STKc_CASK; Catalytic domain of the Serine/Threonine Kinase, Calcium/calmodulin-dependent serine protein kinase

pfam00625
Location:733 → 906

Guanylate_kin; Guanylate kinase

pfam02828
Location:406 → 456

L27; L27 domain
XM_011247441.4 → XP_011245743.1 peripheral plasma membrane protein CASK isoform X23

See identical proteins and their annotated locations for XP_011245743.1

UniProtKB/TrEMBL

B7ZP42

Conserved Domains (6) summary

smart00569
Location:348 → 401

L27; domain in receptor targeting proteins Lin-2 and Lin-7

cd12081
Location:593 → 654

SH3_CASK; Src Homology 3 domain of Calcium/calmodulin-dependent Serine protein Kinase

cd00992
Location:488 → 568

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd14094
Location:8 → 313

STKc_CASK; Catalytic domain of the Serine/Threonine Kinase, Calcium/calmodulin-dependent serine protein kinase

pfam00625
Location:715 → 888

Guanylate_kin; Guanylate kinase

pfam02828
Location:406 → 456

L27; L27 domain
XM_036161801.1 → XP_036017694.1 peripheral plasma membrane protein CASK isoform X17

UniProtKB/TrEMBL

B7ZP42

Conserved Domains (6) summary

smart00569
Location:348 → 401

L27; domain in receptor targeting proteins Lin-2 and Lin-7

cd12081
Location:616 → 677

SH3_CASK; Src Homology 3 domain of Calcium/calmodulin-dependent Serine protein Kinase

cd00992
Location:488 → 568

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd14094
Location:8 → 313

STKc_CASK; Catalytic domain of the Serine/Threonine Kinase, Calcium/calmodulin-dependent serine protein kinase

pfam00625
Location:733 → 906

Guanylate_kin; Guanylate kinase

pfam02828
Location:406 → 456

L27; L27 domain
XM_036161800.1 → XP_036017693.1 peripheral plasma membrane protein CASK isoform X15

UniProtKB/TrEMBL

B7ZP42

Conserved Domains (6) summary

smart00569
Location:348 → 401

L27; domain in receptor targeting proteins Lin-2 and Lin-7

cd12081
Location:616 → 677

SH3_CASK; Src Homology 3 domain of Calcium/calmodulin-dependent Serine protein Kinase

cd00992
Location:488 → 568

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd14094
Location:8 → 313

STKc_CASK; Catalytic domain of the Serine/Threonine Kinase, Calcium/calmodulin-dependent serine protein kinase

pfam00625
Location:738 → 911

Guanylate_kin; Guanylate kinase

pfam02828
Location:406 → 456

L27; L27 domain
XM_011247438.4 → XP_011245740.1 peripheral plasma membrane protein CASK isoform X13

UniProtKB/TrEMBL

B7ZP42

Conserved Domains (6) summary

smart00569
Location:354 → 407

L27; domain in receptor targeting proteins Lin-2 and Lin-7

cd12081
Location:622 → 683

SH3_CASK; Src Homology 3 domain of Calcium/calmodulin-dependent Serine protein Kinase

cd00992
Location:494 → 574

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd14094
Location:8 → 313

STKc_CASK; Catalytic domain of the Serine/Threonine Kinase, Calcium/calmodulin-dependent serine protein kinase

pfam00625
Location:744 → 917

Guanylate_kin; Guanylate kinase

pfam02828
Location:412 → 462

L27; L27 domain