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    Lgals8 lectin, galactose binding, soluble 8 [ Mus musculus (house mouse) ]

    Gene ID: 56048, updated on 4-Jan-2025

    Summary

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    Official Symbol
    Lgals8provided by MGI
    Official Full Name
    lectin, galactose binding, soluble 8provided by MGI
    Primary source
    MGI:MGI:1928481
    See related
    Ensembl:ENSMUSG00000057554 AllianceGenome:MGI:1928481
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Lgals-8; D13Ertd524e; 1200015E08Rik
    Summary
    Enables carbohydrate binding activity. Acts upstream of or within T cell costimulation and plasma cell differentiation. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Orthologous to human LGALS8 (galectin 8). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Ubiquitous expression in testis adult (RPKM 33.3), bladder adult (RPKM 18.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Lgals8 in Genome Data Viewer
    Location:
    13 A1; 13 4.64 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (12454283..12479857, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (12439402..12464977, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene 5445 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:12487435-12487618 Neighboring gene HEAT repeat containing 1 Neighboring gene predicted gene 5928 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:12552850-12553003 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:12553416-12553525 Neighboring gene STARR-positive B cell enhancer ABC_E5367 Neighboring gene EDAR associated via death domain Neighboring gene VISTA enhancer mm1376 Neighboring gene predicted gene, 30239 Neighboring gene STARR-positive B cell enhancer ABC_E4051

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Galectin-8 Ameliorates Murine Autoimmune Ocular Pathology and Promotes a Regulatory T Cell Response. Sampson JF, et al. PLoS One, 2015. PMID 26126176, Free PMC Article
    2. Galectin-8 tandem-repeat structure is essential for T-cell proliferation but not for co-stimulation. Cattaneo V, et al. Biochem J, 2011 Feb 15. PMID 21091438
    3. Galectin-8 activates dendritic cells and stimulates antigen-specific immune response elicitation. Carabelli J, et al. J Leukoc Biol, 2017 Nov. PMID 28811319
    4. Ablation of the mammalian lectin galectin-8 induces bone defects in mice. Vinik Y, et al. FASEB J, 2018 May. PMID 29259034
    5. Characterization of a double-CRD-mutated Gal-8 recombinant protein that retains co-stimulatory activity on antigen-specific T-cell response. Schroeder MN, et al. Biochem J, 2016 Apr 1. PMID 26795039

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Discovery of galectin-8 as an LILRB4 ligand driving M-MDSCs defines a class of antibodies to fight solid tumors.
      Title: Discovery of galectin-8 as an LILRB4 ligand driving M-MDSCs defines a class of antibodies to fight solid tumors.
    2. Galectin-8 involves in arthritic condylar bone loss via podoplanin/AKT/ERK axis-mediated inflammatory lymphangiogenesis.
      Title: Galectin-8 involves in arthritic condylar bone loss via podoplanin/AKT/ERK axis-mediated inflammatory lymphangiogenesis.
    3. Galectin-8 Downmodulates TLR4 Activation and Impairs Bacterial Clearance in a Mouse Model of Pseudomonas aeruginosa Keratitis.
      Title: Galectin-8 Downmodulates TLR4 Activation and Impairs Bacterial Clearance in a Mouse Model of Pseudomonas aeruginosa Keratitis.
    4. Galectin-8 Senses Phagosomal Damage and Recruits Selective Autophagy Adapter TAX1BP1 To Control Mycobacterium tuberculosis Infection in Macrophages.
      Title: Galectin-8 Senses Phagosomal Damage and Recruits Selective Autophagy Adapter TAX1BP1 To Control Mycobacterium tuberculosis Infection in Macrophages.
    5. Anti-inflammatory Role of Galectin-8 During Trypanosoma cruzi Chronic Infection.
      Title: Anti-inflammatory Role of Galectin-8 During Trypanosoma cruzi Chronic Infection.
    6. The Animal Lectin Galectin-8 Promotes Cytokine Expression and Metastatic Tumor Growth in Mice.
      Title: The Animal Lectin Galectin-8 Promotes Cytokine Expression and Metastatic Tumor Growth in Mice.
    7. Gal-8 expression was reduced in CCl4-induced liver fibrosis model in mice suggesting that Gal-8 is a diagnostic and/or prognostic glycoprotein for liver fibrosis.
      Title: Ginger potentiates the effects of silymarin on liver fibrosis induced by CCL4: the role of galectin-8.
    8. these findings identify gal-8 as a new physiologic player in the regulation of bone mass.
      Title: Ablation of the mammalian lectin galectin-8 induces bone defects in mice.
    9. Galectin-8 regulates antibacterial autophagy through differential recognition of host glycans on damaged phagosomes.
      Title: Cytosolic galectin-3 and -8 regulate antibacterial autophagy through differential recognition of host glycans on damaged phagosomes.
    10. Galectin-8 activates dendritic cells and stimulates antigen-specific immune response elicitation.
      Title: Galectin-8 activates dendritic cells and stimulates antigen-specific immune response elicitation.
    Submit: New GeneRIF Correction See all GeneRIFs (20)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Gene trapped (1) 
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables carbohydrate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables carbohydrate binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables integrin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within T cell costimulation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cellular response to virus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to virus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in lymphatic endothelial cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lymphatic endothelial cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within plasma cell differentiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in xenophagy ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in xenophagy ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    galectin-8
    Names
    galectin-8L
    lectin, galactose binding, soluble 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001199043.1 → NP_001185972.1  galectin-8 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR and uses an alternate in-frame splice site in the 5' coding region, compared to variant 3. Variants 1 and 2 encode the same isoform (1), which is shorter than isoform 2.
      Source sequence(s)
      AC154221, AK004782, BQ033229
      Consensus CDS
      CCDS36592.1
      UniProtKB/Swiss-Prot
      Q9JL15
      UniProtKB/TrEMBL
      Q3U2W5, Q542M5
      Related
      ENSMUSP00000097408.4, ENSMUST00000099820.10
      Conserved Domains (1) summary
      smart00908
      Location:24 → 148
      Gal-bind_lectin; Galactoside-binding lectin

    2. NM_001291055.1 → NP_001277984.1  galectin-8 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) encodes the longest isoform (2).
      Source sequence(s)
      AK075736, AK083350, CJ207511, EF524570
      Consensus CDS
      CCDS70431.1
      UniProtKB/TrEMBL
      A8DIL0, Q3U2W5
      Related
      ENSMUSP00000114200.2, ENSMUST00000144283.2
      Conserved Domains (1) summary
      smart00908
      Location:24 → 148
      Gal-bind_lectin; Galactoside-binding lectin

    3. NM_001291057.1 → NP_001277986.1  galectin-8 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and 5' coding region, initiates translation at a downstream start codon and uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. Variants 4 and 5 encode the same isoform (3), which is shorter than isoform 2.
      Source sequence(s)
      AC154221, AK075736, AK083350, CJ207511
      Consensus CDS
      CCDS70430.1
      UniProtKB/TrEMBL
      Q8C6H0
      Related
      ENSMUSP00000118925.2, ENSMUST00000143693.8
      Conserved Domains (1) summary
      smart00908
      Location:101 → 220
      Gal-bind_lectin; Galactoside-binding lectin

    4. NM_001291060.1 → NP_001277989.1  galectin-8 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and 5' coding region, initiates translation at a downstream start codon and uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. Variants 4 and 5 encode the same isoform (3), which is shorter than isoform 2.
      Source sequence(s)
      AC154221, AK075736, AK083350, CJ207511, EF524570
      Consensus CDS
      CCDS70430.1
      UniProtKB/TrEMBL
      Q8C6H0
      Related
      ENSMUSP00000120210.2, ENSMUST00000135166.8
      Conserved Domains (1) summary
      smart00908
      Location:101 → 220
      Gal-bind_lectin; Galactoside-binding lectin

    5. NM_018886.5 → NP_061374.1  galectin-8 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate in-frame splice site in the 5' coding region, compared to variant 3. Variants 1 and 2 encode the same isoform (1), which is shorter than isoform 2.
      Source sequence(s)
      AC154221, AK004782, AK029526, BQ033229
      Consensus CDS
      CCDS36592.1
      UniProtKB/Swiss-Prot
      Q9JL15
      UniProtKB/TrEMBL
      Q3U2W5, Q542M5
      Related
      ENSMUSP00000097409.4, ENSMUST00000099821.10
      Conserved Domains (1) summary
      smart00908
      Location:24 → 148
      Gal-bind_lectin; Galactoside-binding lectin

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      12454283..12479857 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036158098.1 → XP_036013991.1  galectin-8 isoform X7

      Conserved Domains (1) summary
      smart00908
      Location:92 → 211
      Gal-bind_lectin; Galactoside-binding lectin

    2. XM_011244325.1 → XP_011242627.1  galectin-8 isoform X6

      UniProtKB/TrEMBL
      Q8C6H0
      Conserved Domains (1) summary
      smart00908
      Location:101 → 220
      Gal-bind_lectin; Galactoside-binding lectin

    3. XM_017315547.1 → XP_017171036.1  galectin-8 isoform X4

      UniProtKB/TrEMBL
      Q3U2W5
      Conserved Domains (1) summary
      smart00908
      Location:24 → 148
      Gal-bind_lectin; Galactoside-binding lectin

    4. XM_006516715.2 → XP_006516778.1  galectin-8 isoform X2

      UniProtKB/Swiss-Prot
      Q9JL15
      UniProtKB/TrEMBL
      Q3U2W5, Q542M5
      Related
      ENSMUSP00000115094.2, ENSMUST00000124888.8
      Conserved Domains (1) summary
      smart00908
      Location:24 → 148
      Gal-bind_lectin; Galactoside-binding lectin

    5. XM_030247327.2 → XP_030103187.1  galectin-8 isoform X3

      UniProtKB/TrEMBL
      Q3U2W5
      Conserved Domains (1) summary
      smart00908
      Location:24 → 148
      Gal-bind_lectin; Galactoside-binding lectin

    6. XM_011244321.1 → XP_011242623.1  galectin-8 isoform X1

      UniProtKB/TrEMBL
      A8DIL0, Q3U2W5
      Conserved Domains (1) summary
      smart00908
      Location:24 → 148
      Gal-bind_lectin; Galactoside-binding lectin

    7. XM_017315548.1 → XP_017171037.1  galectin-8 isoform X5

      Conserved Domains (1) summary
      smart00908
      Location:110 → 229
      Gal-bind_lectin; Galactoside-binding lectin

    8. XM_017315549.1 → XP_017171038.1  galectin-8 isoform X6

      UniProtKB/TrEMBL
      Q8C6H0
      Conserved Domains (1) summary
      smart00908
      Location:101 → 220
      Gal-bind_lectin; Galactoside-binding lectin

    9. XM_011244324.1 → XP_011242626.1  galectin-8 isoform X5

      Conserved Domains (1) summary
      smart00908
      Location:110 → 229
      Gal-bind_lectin; Galactoside-binding lectin

    10. XM_011244323.1 → XP_011242625.1  galectin-8 isoform X4

      UniProtKB/TrEMBL
      Q3U2W5
      Conserved Domains (1) summary
      smart00908
      Location:24 → 148
      Gal-bind_lectin; Galactoside-binding lectin

    11. XM_006516714.2 → XP_006516777.1  galectin-8 isoform X2

      UniProtKB/Swiss-Prot
      Q9JL15
      UniProtKB/TrEMBL
      Q3U2W5, Q542M5
      Conserved Domains (1) summary
      smart00908
      Location:24 → 148
      Gal-bind_lectin; Galactoside-binding lectin

    12. XM_011244322.3 → XP_011242624.1  galectin-8 isoform X3

      UniProtKB/TrEMBL
      Q3U2W5
      Conserved Domains (1) summary
      smart00908
      Location:24 → 148
      Gal-bind_lectin; Galactoside-binding lectin

    13. XM_011244320.1 → XP_011242622.1  galectin-8 isoform X1

      UniProtKB/TrEMBL
      A8DIL0, Q3U2W5
      Conserved Domains (1) summary
      smart00908
      Location:24 → 148
      Gal-bind_lectin; Galactoside-binding lectin
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JL15.1 GenPept UniProtKB/Swiss-Prot:Q9JL15

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