Mios meiosis regulator for oocyte development [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Miosprovided by MGI
Official Full Name: meiosis regulator for oocyte developmentprovided by MGI
Primary source: MGI:MGI:2182066
See related: Ensembl:ENSMUSG00000042447 AllianceGenome:MGI:2182066
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable metal ion binding activity. Involved in central nervous system myelin formation; oligodendrocyte progenitor proliferation; and positive regulation of TORC1 signaling. Predicted to be located in several cellular components, including cytosol; lysosomal membrane; and nucleoplasm. Predicted to be part of GATOR2 complex. Predicted to be active in cytoplasm. Is expressed in retina. Orthologous to human MIOS (meiosis regulator for oocyte development). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 5.0), CNS E14 (RPKM 4.0) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 A1; 6 3.51 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (8209111..8240573)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (8209111..8240573)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH127093 (e-PCR)
- UniSTS:207925

AI480664 (e-PCR)
- UniSTS:207926

NoName (e-PCR)
- UniSTS:235384

RH132925 (e-PCR)
- UniSTS:216208

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in cellular response to amino acid starvation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to amino acid starvation	IEA Inferred from Electronic Annotation more info
involved_in cellular response to amino acid starvation	ISO Inferred from Sequence Orthology more info
involved_in cellular response to nutrient levels	ISO Inferred from Sequence Orthology more info
involved_in cellular response to nutrient levels	ISS Inferred from Sequence or Structural Similarity more info
involved_in central nervous system myelin formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oligodendrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oligodendrocyte progenitor proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of TORC1 signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of TORC1 signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of TORC1 signaling	ISO Inferred from Sequence Orthology more info
involved_in protein-containing complex localization	IEA Inferred from Electronic Annotation more info
involved_in protein-containing complex localization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of GATOR2 complex	ISO Inferred from Sequence Orthology more info
part_of GATOR2 complex	ISS Inferred from Sequence or Structural Similarity more info
located_in cell junction	IEA Inferred from Electronic Annotation more info
located_in cell junction	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in lysosomal membrane	ISO Inferred from Sequence Orthology more info
located_in lysosomal membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: GATOR2 complex protein MIOS

Names: GATOR complex protein MIOS; WD repeat-containing protein mio; missing oocyte, meiosis regulator, homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_145374.2 → NP_663349.2 GATOR2 complex protein MIOS

See identical proteins and their annotated locations for NP_663349.2

Status: VALIDATED

Source sequence(s)

AK034623, AK079844, BP765255, BQ876300, BU510538, BY064617, CD807728, CX565910

Consensus CDS

CCDS39425.1

UniProtKB/Swiss-Prot

E9QM00, Q8VE19

Related

ENSMUSP00000039301.8, ENSMUST00000040017.8

Conserved Domains (3) summary

COG2319
Location:97 → 368

WD40; WD40 repeat [General function prediction only]

sd00039
Location:64 → 105

7WD40; WD40 repeat [structural motif]

cd16691
Location:782 → 858

mRING-H2-C3H3C2_Mio; Modified RING finger, H2 subclass (C3H3C2-type), found in WD repeat-containing protein mio and simialr proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

8209111..8240573

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036166131.1 → XP_036022024.1 GATOR2 complex protein MIOS isoform X2

Conserved Domains (3) summary

COG2319
Location:97 → 368

WD40; WD40 repeat [General function prediction only]

sd00039
Location:64 → 105

7WD40; WD40 repeat [structural motif]

cd16691
Location:697 → 791

mRING-H2-C3H3C2_Mio; Modified RING finger, H2 subclass (C3H3C2-type), found in WD repeat-containing protein mio and simialr proteins
XM_036166132.1 → XP_036022025.1 GATOR2 complex protein MIOS isoform X3

Conserved Domains (3) summary

COG2319
Location:97 → 368

WD40; WD40 repeat [General function prediction only]

sd00039
Location:64 → 105

7WD40; WD40 repeat [structural motif]

cd16691
Location:697 → 773

mRING-H2-C3H3C2_Mio; Modified RING finger, H2 subclass (C3H3C2-type), found in WD repeat-containing protein mio and simialr proteins
XM_036166130.1 → XP_036022023.1 GATOR2 complex protein MIOS isoform X1

Conserved Domains (3) summary

sd00039
Location:64 → 105

7WD40; WD40 repeat [structural motif]

cd16691
Location:782 → 876

mRING-H2-C3H3C2_Mio; Modified RING finger, H2 subclass (C3H3C2-type), found in WD repeat-containing protein mio and simialr proteins

cl29593
Location:112 → 299

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_036166129.1 → XP_036022022.1 GATOR2 complex protein MIOS isoform X1

Conserved Domains (3) summary

sd00039
Location:64 → 105

7WD40; WD40 repeat [structural motif]

cd16691
Location:782 → 876

mRING-H2-C3H3C2_Mio; Modified RING finger, H2 subclass (C3H3C2-type), found in WD repeat-containing protein mio and simialr proteins

cl29593
Location:112 → 299

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...