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    Bard1 BRCA1 associated RING domain 1 [ Mus musculus (house mouse) ]

    Gene ID: 12021, updated on 4-Jan-2025

    Summary

    Official Symbol
    Bard1provided by MGI
    Official Full Name
    BRCA1 associated RING domain 1provided by MGI
    Primary source
    MGI:MGI:1328361
    See related
    Ensembl:ENSMUSG00000026196 AllianceGenome:MGI:1328361
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable RNA binding activity; protein heterodimerization activity; and protein homodimerization activity. Predicted to contribute to ubiquitin-protein transferase activity. Predicted to be involved in several processes, including negative regulation of protein export from nucleus; protein K6-linked ubiquitination; and regulation of apoptotic process. Located in nucleus. Is expressed in central nervous system; genitourinary system; limb; and spleen. Used to study breast cancer. Human ortholog(s) of this gene implicated in breast cancer and ovarian cancer. Orthologous to human BARD1 (BRCA1 associated RING domain 1). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Broad expression in liver E14 (RPKM 5.7), liver E14.5 (RPKM 5.1) and 18 other tissues See more
    Orthologs
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    Genomic context

    See Bard1 in Genome Data Viewer
    Location:
    1 C3; 1 35.67 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (71066694..71142300, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (71027535..71103141, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene von Willebrand factor C domain-containing protein 2-like Neighboring gene STARR-seq mESC enhancer starr_01230 Neighboring gene predicted gene, 29906 Neighboring gene predicted gene, 57799 Neighboring gene ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E5769 Neighboring gene STARR-seq mESC enhancer starr_01231 Neighboring gene STARR-seq mESC enhancer starr_01232 Neighboring gene predicted gene, 53490 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:71149481-71149668 Neighboring gene STARR-seq mESC enhancer starr_01235 Neighboring gene ribosomal protein L7A pseudogene Neighboring gene predicted gene, 53560

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding PubMed 
    enables metal ion binding  
    enables protein heterodimerization activity  
    enables protein heterodimerization activity  
    enables protein homodimerization activity  
    enables protein homodimerization activity  
    contributes_to ubiquitin-protein transferase activity  
    contributes_to ubiquitin-protein transferase activity  
    contributes_to ubiquitin-protein transferase activity  
    Process Evidence Code Pubs
    involved_in DNA damage response PubMed 
    involved_in DNA repair PubMed 
    involved_in DNA strand resection involved in replication fork processing PubMed 
    involved_in cellular response to ionizing radiation  
    involved_in homologous recombination PubMed 
    involved_in mitotic G2/M transition checkpoint PubMed 
    involved_in negative regulation of apoptotic process  
    involved_in negative regulation of apoptotic process  
    involved_in negative regulation of protein export from nucleus  
    involved_in negative regulation of protein export from nucleus  
    involved_in positive regulation of apoptotic process  
    involved_in positive regulation of apoptotic process  
    involved_in positive regulation of cell cycle PubMed 
    involved_in protein K6-linked ubiquitination  
    involved_in protein K6-linked ubiquitination  
    involved_in protein K6-linked ubiquitination  
    involved_in regulation of DNA damage checkpoint PubMed 
    involved_in regulation of DNA repair PubMed 
    involved_in regulation of phosphorylation  
    involved_in regulation of phosphorylation  
    Component Evidence Code Pubs
    part_of BRCA1-A complex  
    part_of BRCA1-A complex  
    part_of BRCA1-A complex PubMed 
    part_of BRCA1-B complex  
    part_of BRCA1-BARD1 complex  
    part_of BRCA1-BARD1 complex  
    part_of BRCA1-BARD1 complex  
    part_of BRCA1-C complex  
    located_in cytoplasm  
    located_in cytoplasm  
    located_in cytoplasmic ribonucleoprotein granule  
    located_in cytoplasmic ribonucleoprotein granule  
    located_in nuclear speck  
    located_in nuclear speck  
    part_of nuclear ubiquitin ligase complex  
    located_in nucleoplasm  
    located_in nucleus PubMed 
    located_in nucleus  
    located_in nucleus  
    located_in nucleus PubMed 

    General protein information

    Preferred Names
    BRCA1-associated RING domain protein 1
    Names
    BARD-1
    RING-type E3 ubiquitin transferase BARD1
    NP_001406889.1
    NP_031551.1
    XP_006495695.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001419960.1NP_001406889.1  BRCA1-associated RING domain protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC104747
      UniProtKB/TrEMBL
      Q3ULG2
    2. NM_007525.3NP_031551.1  BRCA1-associated RING domain protein 1 isoform 1

      See identical proteins and their annotated locations for NP_031551.1

      Status: VALIDATED

      Source sequence(s)
      AC104747
      Consensus CDS
      CCDS15029.1
      UniProtKB/Swiss-Prot
      A2VCQ1, O70445
      UniProtKB/TrEMBL
      Q3ULG2
      Related
      ENSMUSP00000027393.8, ENSMUST00000027393.8
      Conserved Domains (6) summary
      smart00292
      Location:558628
      BRCT; breast cancer carboxy-terminal domain
      cd00204
      Location:412532
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:420512
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:391436
      Ank_4; Ankyrin repeats (many copies)
      pfam14835
      Location:3599
      zf-RING_6; zf-RING of BARD1-type protein
      sd00045
      Location:415446
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      71066694..71142300 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006495632.4XP_006495695.1  BRCA1-associated RING domain protein 1 isoform X2

      Conserved Domains (4) summary
      sd00045
      Location:415446
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:420510
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:391436
      Ank_4; Ankyrin repeats (many copies)
      pfam14835
      Location:3599
      zf-RING_6; zf-RING of BARD1-type protein

    RNA

    1. XR_003947336.1 RNA Sequence

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