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    Serpinb3a serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 3A [ Mus musculus (house mouse) ]

    Gene ID: 20248, updated on 9-Dec-2024

    Summary

    Official Symbol
    Serpinb3aprovided by MGI
    Official Full Name
    serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 3Aprovided by MGI
    Primary source
    MGI:MGI:3573933
    See related
    Ensembl:ENSMUSG00000044594 AllianceGenome:MGI:3573933
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Sqn5; Scca2; Serpinb4; 1110001H02Rik; 1110013A16Rik
    Summary
    Predicted to enable endopeptidase inhibitor activity; protease binding activity; and virus receptor activity. Predicted to be involved in negative regulation of endopeptidase activity. Predicted to be located in several cellular components, including cytoplasmic vesicle; cytosol; and extracellular exosome. Predicted to be active in extracellular space. Orthologous to human SERPINB3 (serpin family B member 3) and SERPINB4 (serpin family B member 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in lung adult (RPKM 6.2), stomach adult (RPKM 0.8) and 1 other tissue See more
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    Genomic context

    See Serpinb3a in Genome Data Viewer
    Location:
    1 E2.1; 1 50.34 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (106973317..106980033, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (107045587..107052303, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene 4.5s RNA, pseudogene 1 Neighboring gene serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 3D pseudogene Neighboring gene serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 3D Neighboring gene STARR-seq mESC enhancer starr_01865 Neighboring gene STARR-seq mESC enhancer starr_01866 Neighboring gene ribosomal protein S6 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1)  1 citation

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cysteine-type endopeptidase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protease binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables serine-type endopeptidase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables serine-type endopeptidase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables virus receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in negative regulation of endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    serine peptidase inhibitor, clade B, member 3A
    Names
    serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 3A
    squamous cell carcinoma antigen 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009126.3NP_033152.3  serine peptidase inhibitor, clade B, member 3A

      Status: VALIDATED

      Source sequence(s)
      AC125111, BB699605, BC063756
      Consensus CDS
      CCDS15214.1
      UniProtKB/TrEMBL
      G3X9V8, Q8BG86
      Related
      ENSMUSP00000108337.2, ENSMUST00000112717.3
      Conserved Domains (1) summary
      cl00137
      Location:5387
      SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      106973317..106980033 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)