Rgn regucalcin [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rgnprovided by MGI
Official Full Name: regucalcinprovided by MGI
Primary source: MGI:MGI:108024
See related: Ensembl:ENSMUSG00000023070 AllianceGenome:MGI:108024
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: RC; GNL; SMP30; SMP-30
Summary: Enables gluconolactonase activity. Involved in L-ascorbic acid biosynthetic process. Located in cytoplasm and nucleus. Is expressed in alimentary system; liver; and liver lobe. Orthologous to human RGN (regucalcin). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in liver E18 (RPKM 208.8), liver adult (RPKM 124.7) and 2 other tissues See more
Orthologs: human all
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Genomic context

Location:: X A1.3; X 16.04 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (20413980..20428328)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (20549766..20562089)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The inflammatory macrophages repress the growth of bone metastatic human prostate cancer cells via TNF-alpha and IL-6 signaling: Involvement of cell signaling regulator regucalcin.
Title: The inflammatory macrophages repress the growth of bone metastatic human prostate cancer cells via TNF-α and IL-6 signaling: Involvement of cell signaling regulator regucalcin.
SMP30-mediated synthesis of vitamin C activates the liver PPARalpha/FGF21 axis to regulate thermogenesis in mice.
Title: SMP30-mediated synthesis of vitamin C activates the liver PPARα/FGF21 axis to regulate thermogenesis in mice.
Regucalcin enhances adipocyte differentiation and attenuates inflammation in 3T3-L1 cells.
Title: Regucalcin enhances adipocyte differentiation and attenuates inflammation in 3T3-L1 cells.
Senescence marker protein 30 confers neuroprotection in oxygen-glucose deprivation/reoxygenation-injured neurons through modulation of Keap1/Nrf2 signaling: Role of SMP30 in OGD/R-induced neuronal injury.
Title: Senescence marker protein 30 confers neuroprotection in oxygen-glucose deprivation/reoxygenation-injured neurons through modulation of Keap1/Nrf2 signaling: Role of SMP30 in OGD/R-induced neuronal injury.
Regucalcin promotes dormancy of prostate cancer.
Title: Regucalcin promotes dormancy of prostate cancer.
Systemic ascorbic acid deficiency can be induced in GNL/SMP30-KO mice.
Title: Dietary ascorbic acid restriction in GNL/SMP30-knockout mice unveils the role of ascorbic acid in regulation of somatic and visceral pain sensitivity.
In SMP30 deficient mice, colitis was significantly exacerbated as demonstrated by increased mortality (p=0.001), body weight loss (p=0.0105 at day 8), rectal bleeding (p=0.0047 at day 8) and diarrhea (p=0.0030 at day 8), histological scores (ulcers, p=0.0002; edema, p=0.0125; leukocyte infiltration, p=0.0016) and productions of pro-inflammatory cytokines (IL-1alpha, p=0.0452; IL-6, p=0.0074; G-CSF).
Title: Senescence marker protein 30 protects intestinal epithelial cells against inflammation-induced cell death by enhancing Nrf2 activity.
It was confirmed that hair growth was significantly promoted; hair growth from hair papilla cells was also confirmed by HE staining of the shaved backs of SMP-30/GNL-KO mice in the vitamin C(+) group
Title: Transcriptome Analysis of Skin from SMP30/GNL Knockout Mice Reveals the Effect of Ascorbic Acid Deficiency on Skin and Hair.
The phosphorylated eNOS and Akt levels and VEGF levels in ischemic muscle were lower in SMP30 KO and old mice than in young mice. Deficiency of SMP30 exacerbates oxidative stress related to NADPH oxidase activity enhancement and impairs eNOS activity, which leads to rarefaction of angiogenesis induced by ischemia
Title: Senescence marker protein-30 deficiency impairs angiogenesis under ischemia.
Results suggested that SMP30 deficiency augments myocardial Ischemia/Reperfusion injury through reactive oxygen species generation and attenuation of Akt activation.
Title: Deficiency of Senescence Marker Protein 30 Exacerbates Cardiac Injury after Ischemia/Reperfusion.

Submit: New GeneRIF Correction See all GeneRIFs (44)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (1) 1 citation

General gene information

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Markers

AI265316 (e-PCR)
- UniSTS:160874

RH142290 (e-PCR)
- UniSTS:231537

NoName (e-PCR)
- UniSTS:225273

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables enzyme regulator activity	IEA Inferred from Electronic Annotation more info
enables gluconolactonase activity	IBA Inferred from Biological aspect of Ancestor more info
enables gluconolactonase activity	IDA Inferred from Direct Assay more info	PubMed
enables gluconolactonase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables gluconolactonase activity	ISO Inferred from Sequence Orthology more info
enables gluconolactonase activity	ISS Inferred from Sequence or Structural Similarity more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in L-ascorbic acid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in L-ascorbic acid biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in L-ascorbic acid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular calcium ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in intracellular calcium ion homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in kidney development	IEA Inferred from Electronic Annotation more info
involved_in liver regeneration	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA catabolic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA catabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of RNA biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of RNA biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of bone development	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of bone development	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of epithelial cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of flagellated sperm motility	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of flagellated sperm motility	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of nitric oxide biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of nitric oxide biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ATP-dependent activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of fatty acid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of fatty acid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of glucose metabolic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of glucose metabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of proteolysis involved in protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of proteolysis involved in protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of triglyceride biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of triglyceride biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of calcium-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in regulation of calcium-mediated signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in spermatogenesis	IEA Inferred from Electronic Annotation more info
involved_in spermatogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: regucalcin

Names: gluconolactonase; senescence marker protein 30

NP_001404943.1

EC 3.1.1.17

NP_001404944.1

EC 3.1.1.17

NP_001404945.1

EC 3.1.1.17

NP_001404946.1

EC 3.1.1.17

NP_033086.1

EC 3.1.1.17

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.