Rac3 Rac family small GTPase 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rac3provided by MGI
Official Full Name: Rac family small GTPase 3provided by MGI
Primary source: MGI:MGI:2180784
See related: Ensembl:ENSMUSG00000018012 AllianceGenome:MGI:2180784
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Rac1B
Summary: Predicted to enable several functions, including GTP binding activity; GTPase activity; and calcium-dependent protein binding activity. Involved in regulation of postsynapse assembly. Acts upstream of or within several processes, including GABAergic synaptic transmission; neuron development; and regulation of neuron maturation. Is active in glutamatergic synapse and postsynapse. Is expressed in brain and genitourinary system. Orthologous to human RAC3 (Rac family small GTPase 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in CNS E18 (RPKM 162.4), whole brain E14.5 (RPKM 74.7) and 10 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 E2; 11 84.46 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (120612294..120614795)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (120721468..120723969)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Dispensable role of Rac1 and Rac3 after cochlear hair cell specification.
Title: Dispensable role of Rac1 and Rac3 after cochlear hair cell specification.
Rac1 and Rac3 GTPases and TPC2 are required for axonal outgrowth and migration of cortical interneurons.
Title: Rac1 and Rac3 GTPases and TPC2 are required for axonal outgrowth and migration of cortical interneurons.
RAC1B function is essential for breast cancer stem cell maintenance and chemoresistance of breast tumor cells.
Title: RAC1B function is essential for breast cancer stem cell maintenance and chemoresistance of breast tumor cells.
Rac-deficient cerebellar granule neurons die before they migrate to the internal granule layer.
Title: Rac-deficient cerebellar granule neurons die before they migrate to the internal granule layer.
Negative regulation of TGFbeta-induced apoptosis by RAC1B enhances intestinal tumourigenesis.
Title: Negative regulation of TGFβ-induced apoptosis by RAC1B enhances intestinal tumourigenesis.
Rac1 and Rac3 have opposite functions in Schwann cells during developmental myelination.
Title: Rac1 and Rac3 have opposite functions in Schwann cells during developmental myelination.
Knockdown of Rac3 resulted in mislocalization of neonatally born dentate granule cells. Despite the ectopic localization, Rac3- or Cdc42-disrupted mispositioned cells expressed Prox1.
Title: Rho family GTPases, Rac and Cdc42, control the localization of neonatal dentate granule cells during brain development.
role in morphological maturation of dendritic spines in hippocampal neurons
Title: Rac1 and Rac3 GTPases differently influence the morphological maturation of dendritic spines in hippocampal neurons.
Rac3 regulates breast cancer invasion and metastasis by controlling adhesion and matrix degradation.
Title: Rac3 regulates breast cancer invasion and metastasis by controlling adhesion and matrix degradation.
The results of this study show that Rac3 have a roles in the formation of GABAergic circuits, as highlighted by the differential effects of their deletion on the late maturation of specific populations.
Title: Loss of Either Rac1 or Rac3 GTPase Differentially Affects the Behavior of Mutant Mice and the Development of Functional GABAergic Networks.

Submit: New GeneRIF Correction See all GeneRIFs (24)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein activity	IEA Inferred from Electronic Annotation more info
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	ISO Inferred from Sequence Orthology more info
enables GTPase activity	ISS Inferred from Sequence or Structural Similarity more info
enables calcium-dependent protein binding	IEA Inferred from Electronic Annotation more info
enables calcium-dependent protein binding	ISO Inferred from Sequence Orthology more info
enables membrane scission GTPase motor activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in Rac protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in actin cytoskeleton organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in actin filament organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell projection assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell projection assembly	ISO Inferred from Sequence Orthology more info
involved_in cell projection assembly	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within cerebral cortex GABAergic interneuron development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cortical cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment or maintenance of cell polarity	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within homeostasis of number of cells within a tissue	IGI Inferred from Genetic Interaction more info	PubMed
involved_in motor neuron axon guidance	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within neuromuscular process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuromuscular process controlling balance	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuron projection development	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cell adhesion mediated by integrin	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell adhesion mediated by integrin	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of substrate adhesion-dependent cell spreading	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of substrate adhesion-dependent cell spreading	ISS Inferred from Sequence or Structural Similarity more info
involved_in postsynaptic actin cytoskeleton organization	IEA Inferred from Electronic Annotation more info
involved_in postsynaptic actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of actin cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of cell morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of cell shape	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of neuron maturation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of neutrophil migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of postsynapse assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of postsynapse assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in small GTPase-mediated signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within synaptic transmission, GABAergic	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in cell periphery	ISO Inferred from Sequence Orthology more info
located_in cell periphery	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytoplasmic vesicle	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in endomembrane system	ISO Inferred from Sequence Orthology more info
located_in endomembrane system	ISS Inferred from Sequence or Structural Similarity more info
part_of filamentous actin	ISO Inferred from Sequence Orthology more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in growth cone	ISO Inferred from Sequence Orthology more info	PubMed
located_in lamellipodium	IEA Inferred from Electronic Annotation more info
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
located_in neuron projection	ISO Inferred from Sequence Orthology more info	PubMed
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info	PubMed
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in postsynapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynapse	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: ras-related C3 botulinum toxin substrate 3

Names: RAS-related C3 botulinum substrate 3; p21-Rac3

NP_573486.1

EC 3.6.5.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_133223.4 → NP_573486.1 ras-related C3 botulinum toxin substrate 3

See identical proteins and their annotated locations for NP_573486.1

Status: PROVISIONAL

Source sequence(s)

AL663030

Consensus CDS

CCDS25754.1

UniProtKB/Swiss-Prot

P60764

UniProtKB/TrEMBL

Q14A12, Q8BPG5, Q9D859

Related

ENSMUSP00000018156.6, ENSMUST00000018156.12

Conserved Domains (1) summary

cd01871
Location:3 → 176

Rac1_like; Ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)-like consists of Rac1, Rac2 and Rac3