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    Zbtb12 zinc finger and BTB domain containing 12 [ Mus musculus (house mouse) ]

    Gene ID: 193736, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zbtb12provided by MGI
    Official Full Name
    zinc finger and BTB domain containing 12provided by MGI
    Primary source
    MGI:MGI:88133
    See related
    Ensembl:ENSMUSG00000049823 AllianceGenome:MGI:88133
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    G10; Bat9; NG35; Bat-9
    Summary
    Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; regulation of cytokine production; and regulation of immune system process. Predicted to be active in nucleoplasm. Orthologous to human ZBTB12 (zinc finger and BTB domain containing 12). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in CNS E14 (RPKM 33.4), whole brain E14.5 (RPKM 32.0) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zbtb12 in Genome Data Viewer
    Location:
    17 B1; 17 18.43 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (35113514..35115820)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (34894559..34896867)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene microRNA 6972 Neighboring gene complement factor B Neighboring gene complement C2 Neighboring gene STARR-seq mESC enhancer starr_42440 Neighboring gene predicted gene, 40706 Neighboring gene euchromatic histone lysine N-methyltransferase 2 Neighboring gene solute carrier family 44, member 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. P1 and cosmid clones define the organization of 280 kb of the mouse H-2 complex containing the Cps-1 and Hsp70 loci. Gasser DL, et al. Immunogenetics, 1994. PMID 7993390
    2. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    3. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cytokine production IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of immune system process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger and BTB domain-containing protein 12
    Names
    HLA-B-associated transcript 9

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001410323.1 → NP_001397252.1  zinc finger and BTB domain-containing protein 12 isoform 1

      Status: VALIDATED

      Source sequence(s)
      CT025759
      UniProtKB/TrEMBL
      Q6P6L4, Q9Z150

    2. NM_001410324.1 → NP_001397253.1  zinc finger and BTB domain-containing protein 12 isoform 2

      Status: VALIDATED

      Source sequence(s)
      CT025759

    3. NM_198886.4 → NP_942589.3  zinc finger and BTB domain-containing protein 12 isoform 1

      See identical proteins and their annotated locations for NP_942589.3

      Status: VALIDATED

      Source sequence(s)
      CT025759
      Consensus CDS
      CCDS28665.1
      UniProtKB/TrEMBL
      Q6P6L4, Q9Z150
      Related
      ENSMUSP00000057515.9, ENSMUST00000052778.10
      Conserved Domains (5) summary
      COG5048
      Location:361 → 448
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:361 → 381
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:359 → 381
      zf-C2H2; Zinc finger, C2H2 type
      cd18203
      Location:8 → 129
      BTB_POZ_ZBTB12; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 12 (ZBTB12)
      pfam13465
      Location:373 → 398
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      35113514..35115820
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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