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    Tafa2 TAFA chemokine like family member 2 [ Mus musculus (house mouse) ]

    Gene ID: 268354, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tafa2provided by MGI
    Official Full Name
    TAFA chemokine like family member 2provided by MGI
    Primary source
    MGI:MGI:2143691
    See related
    Ensembl:ENSMUSG00000044071 AllianceGenome:MGI:2143691
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Sam2; Tafa-2; Fam19a2; 6330575M02; FAM19A2 TAFA-2
    Summary
    This gene is a member of the TAFA family which is composed of five highly homologous genes that encode small secreted proteins. These proteins contain conserved cysteine residues at fixed positions, and are distantly related to MIP-1alpha, a member of the CC-chemokine family. The TAFA proteins are predominantly expressed in specific regions of the brain, and are postulated to function as brain-specific chemokines or neurokines that act as regulators of immune and nervous cells. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in CNS E18 (RPKM 7.3), whole brain E14.5 (RPKM 3.8) and 6 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tafa2 in Genome Data Viewer
    Location:
    10 D2; 10 72.31 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (123099813..123577109)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (123264024..123741204)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene ubiquitin specific peptidase 15 Neighboring gene predicted gene, 36628 Neighboring gene predicted gene 4129 Neighboring gene STARR-seq mESC enhancer starr_28144 Neighboring gene predicted gene, 22958 Neighboring gene predicted gene, 40794 Neighboring gene TPX2, microtubule-associated protein homolog pseudogene Neighboring gene STARR-seq mESC enhancer starr_28146 Neighboring gene crumbs homolog 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_28147 Neighboring gene eukaryotic translation initiation factor 3, subunit I pseudogene Neighboring gene STARR-seq mESC enhancer starr_28148

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Tafa-2 plays an essential role in neuronal survival and neurobiological function in mice. Wang X, et al. Acta Biochim Biophys Sin (Shanghai), 2018 Oct 1. PMID 30137205, Free PMC Article
    2. Neuronal survival factor TAFA2 suppresses apoptosis through binding to ADGRL1 and activating cAMP/PKA/CREB/BCL2 signaling pathway. Liang H, et al. Life Sci, 2023 Dec 1. PMID 37944639
    3. TAFA: a novel secreted family with conserved cysteine residues and restricted expression in the brain. Tom Tang Y, et al. Genomics, 2004 Apr. PMID 15028294
    4. Molecular logic of cellular diversification in the mouse cerebral cortex. Di Bella DJ, et al. Nature, 2021 Jul. PMID 34163074, Free PMC Article
    5. Pyramidal neurons form active, transient, multilayered circuits perturbed by autism-associated mutations at the inception of neocortex. Munz M, et al. Cell, 2023 Apr 27. PMID 37071993, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Neuronal survival factor TAFA2 suppresses apoptosis through binding to ADGRL1 and activating cAMP/PKA/CREB/BCL2 signaling pathway.
      Title: Neuronal survival factor TAFA2 suppresses apoptosis through binding to ADGRL1 and activating cAMP/PKA/CREB/BCL2 signaling pathway.
    2. chemokine-like protein TAFA-2
      Title: Tafa-2 plays an essential role in neuronal survival and neurobiological function in mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables receptor ligand activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in memory IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in visual learning IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    chemokine-like protein TAFA-2
    Names
    family with sequence similarity 19, member A2
    protein FAM19A2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001252387.1 → NP_001239316.1  chemokine-like protein TAFA-2 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001239316.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an exon and uses a downstream, in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AK140763, AK164201, BC027082, CD350359
      Consensus CDS
      CCDS88096.1
      UniProtKB/Swiss-Prot
      Q5M9Q3, Q7TPG7
      Related
      ENSMUSP00000159016.2, ENSMUST00000238972.2
      Conserved Domains (1) summary
      pfam12020
      Location:41 → 129
      TAFA; TAFA family

    2. NM_182807.3 → NP_877959.2  chemokine-like protein TAFA-2 isoform 1 precursor

      See identical proteins and their annotated locations for NP_877959.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AK140763, BC027082, CD350359
      Consensus CDS
      CCDS48709.1
      UniProtKB/TrEMBL
      A0A0R4J0M7
      Related
      ENSMUSP00000050199.8, ENSMUST00000050756.8
      Conserved Domains (1) summary
      pfam12020
      Location:45 → 133
      TAFA; TAFA family

    RNA

    1. NR_045514.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an internal exon in the 5' region and includes an alternate internal exon in the 3' region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK139403, AK140763, BC027082, CD350359
      Related
      ENSMUST00000218926.2

    2. NR_153334.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AK140763, BC027082, CD350359

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      123099813..123577109
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017313953.3 → XP_017169442.1  chemokine-like protein TAFA-2 isoform X1

      Conserved Domains (1) summary
      pfam12020
      Location:80 → 167
      TAFA; TAFA family

    2. XM_017313952.3 → XP_017169441.1  chemokine-like protein TAFA-2 isoform X2

      Conserved Domains (1) summary
      pfam12020
      Location:80 → 168
      TAFA; TAFA family

    3. XM_036155793.1 → XP_036011686.1  chemokine-like protein TAFA-2 isoform X1

      Conserved Domains (1) summary
      pfam12020
      Location:80 → 167
      TAFA; TAFA family

    4. XM_036155794.1 → XP_036011687.1  chemokine-like protein TAFA-2 isoform X4

      Conserved Domains (1) summary
      pfam12020
      Location:45 → 132
      TAFA; TAFA family

    5. XM_030245097.2 → XP_030100957.1  chemokine-like protein TAFA-2 isoform X3

      UniProtKB/TrEMBL
      A0A0R4J0M7
      Conserved Domains (1) summary
      pfam12020
      Location:45 → 133
      TAFA; TAFA family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7TPG7.1 GenPept UniProtKB/Swiss-Prot:Q7TPG7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
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