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    Ptrh2 peptidyl-tRNA hydrolase 2 [ Mus musculus (house mouse) ]

    Gene ID: 217057, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ptrh2provided by MGI
    Official Full Name
    peptidyl-tRNA hydrolase 2provided by MGI
    Primary source
    MGI:MGI:2444848
    See related
    Ensembl:ENSMUSG00000072582 AllianceGenome:MGI:2444848
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Bit1; PTH 2; CGI-147; A230072I16Rik
    Summary
    Predicted to enable aminoacyl-tRNA hydrolase activity. Predicted to be involved in negative regulation of anoikis; negative regulation of gene expression; and positive regulation of anoikis. Located in mitochondrion. Is expressed in embryo. Orthologous to human PTRH2 (peptidyl-tRNA hydrolase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 10.6), liver E14 (RPKM 7.5) and 27 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Ptrh2 in Genome Data Viewer
    Location:
    11 C; 11 51.82 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (86574900..86583283)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (86684074..86692457)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene vacuole membrane protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E3988 Neighboring gene predicted gene, 51914 Neighboring gene STARR-seq mESC enhancer starr_30272 Neighboring gene predicted gene 11478 Neighboring gene STARR-seq mESC enhancer starr_30273 Neighboring gene STARR-seq mESC enhancer starr_30274 Neighboring gene STARR-positive B cell enhancer ABC_E11770 Neighboring gene STARR-seq mESC enhancer starr_30275 Neighboring gene STARR-positive B cell enhancer ABC_E3989 Neighboring gene clathrin heavy chain Neighboring gene STARR-positive B cell enhancer ABC_E7036 Neighboring gene STARR-seq mESC enhancer starr_30277 Neighboring gene predicted gene, 42085 Neighboring gene STARR-seq mESC enhancer starr_30279 Neighboring gene DEAH-box helicase 40

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (2)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables aminoacyl-tRNA hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables aminoacyl-tRNA hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables aminoacyl-tRNA hydrolase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in negative regulation of anoikis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of anoikis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of anoikis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of anoikis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of anoikis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of anoikis ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial outer membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial outer membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    peptidyl-tRNA hydrolase 2, mitochondrial
    NP_001092280.1
    NP_778169.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001098810.3NP_001092280.1  peptidyl-tRNA hydrolase 2, mitochondrial isoform b

      See identical proteins and their annotated locations for NP_001092280.1

      Status: VALIDATED

      Source sequence(s)
      AA271949, AK031620, AK038888
      Consensus CDS
      CCDS48876.1
      UniProtKB/Swiss-Prot
      Q8BI01, Q8BI31, Q8R2Y8
      Related
      ENSMUSP00000103657.2, ENSMUST00000108022.8
      Conserved Domains (1) summary
      cd02430
      Location:67181
      PTH2; Peptidyl-tRNA hydrolase, type 2 (PTH2). Peptidyl-tRNA hydrolase (PTH) activity releases tRNA from the premature translation termination product peptidyl-tRNA, therefore allowing the tRNA and peptide to be reused in protein synthesis. PTH2 is present in ...
    2. NM_175004.3NP_778169.1  peptidyl-tRNA hydrolase 2, mitochondrial isoform a

      See identical proteins and their annotated locations for NP_778169.1

      Status: VALIDATED

      Source sequence(s)
      AL592222
      UniProtKB/Swiss-Prot
      Q8R2Y8
      Conserved Domains (1) summary
      cd02430
      Location:68182
      PTH2; Peptidyl-tRNA hydrolase, type 2 (PTH2). Peptidyl-tRNA hydrolase (PTH) activity releases tRNA from the premature translation termination product peptidyl-tRNA, therefore allowing the tRNA and peptide to be reused in protein synthesis. PTH2 is present in ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      86574900..86583283
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)