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    Rsrc1 arginine/serine-rich coiled-coil 1 [ Mus musculus (house mouse) ]

    Gene ID: 66880, updated on 9-Dec-2024

    Summary

    Official Symbol
    Rsrc1provided by MGI
    Official Full Name
    arginine/serine-rich coiled-coil 1provided by MGI
    Primary source
    MGI:MGI:1914130
    See related
    Ensembl:ENSMUSG00000034544 AllianceGenome:MGI:1914130
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SRrp53; 1200013F24Rik
    Summary
    Involved in nucleocytoplasmic transport. Acts upstream of or within alternative mRNA splicing, via spliceosome; protein phosphorylation; and response to antibiotic. Located in cytoplasm and nuclear speck. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 70. Orthologous to human RSRC1 (arginine and serine rich coiled-coil 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in genital fat pad adult (RPKM 7.3), thymus adult (RPKM 7.1) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Rsrc1 in Genome Data Viewer
    Location:
    3 E1; 3 30.77 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (66888694..67265736)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (66981364..67358403)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_07879 Neighboring gene predicted gene, 54200 Neighboring gene STARR-seq mESC enhancer starr_07880 Neighboring gene STARR-seq mESC enhancer starr_07881 Neighboring gene STARR-seq mESC enhancer starr_07882 Neighboring gene Shox2 limb hindbrain control region Neighboring gene aminoacyl tRNA synthetase complex-interacting multifunctional protein 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_07883 Neighboring gene SHOX homeobox 2 Neighboring gene predicted gene, 54201 Neighboring gene STARR-seq mESC enhancer starr_07884 Neighboring gene predicted gene, 22295 Neighboring gene STARR-positive B cell enhancer ABC_E6060 Neighboring gene STARR-positive B cell enhancer mm9_chr3:67177807-67178108 Neighboring gene myeloid leukemia factor 1 Neighboring gene G elongation factor, mitochondrial 1 Neighboring gene latexin

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC103357

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nuclear speck IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    serine/Arginine-related protein 53
    Names
    arginine/serine-rich coiled-coil protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356273.2NP_001343202.1  serine/Arginine-related protein 53 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC122870, AC129294, AC134448, AC161425
      UniProtKB/TrEMBL
      Q80XR9
    2. NM_001356274.2NP_001343203.1  serine/Arginine-related protein 53 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC122870, AC129294, AC134448, AC161425
      UniProtKB/TrEMBL
      Q80XR9
    3. NM_001356275.2NP_001343204.1  serine/Arginine-related protein 53 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC122870, AC129294, AC134448, AC161425
      Consensus CDS
      CCDS89635.1
      UniProtKB/TrEMBL
      Q3TGY1, Q8CFJ0
      Related
      ENSMUSP00000047077.7, ENSMUST00000046542.13
    4. NM_001356277.2NP_001343206.1  serine/Arginine-related protein 53 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC122870, AC129294, AC134448, AC161425
      UniProtKB/TrEMBL
      Q8CFJ0
    5. NM_001356278.2NP_001343207.1  serine/Arginine-related protein 53 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC122870, AC129294, AC134448, AC161425
      Consensus CDS
      CCDS89634.1
      UniProtKB/TrEMBL
      E9Q6P8, Q8CFJ0
      Related
      ENSMUSP00000125547.2, ENSMUST00000162693.8
    6. NM_001356279.2NP_001343208.1  serine/Arginine-related protein 53 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC122870, AC129294, AC134448, AC161425
      UniProtKB/TrEMBL
      Q8CFJ0
    7. NM_001356280.2NP_001343209.1  serine/Arginine-related protein 53 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC122870, AC129294, AC134448, AC161425
      UniProtKB/TrEMBL
      Q8BR75
    8. NM_001428932.1NP_001415861.1  serine/Arginine-related protein 53 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC122870, AC129294
    9. NM_001428933.1NP_001415862.1  serine/Arginine-related protein 53 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC122870, AC129294
    10. NM_025822.5NP_080098.1  serine/Arginine-related protein 53 isoform 2

      See identical proteins and their annotated locations for NP_080098.1

      Status: VALIDATED

      Source sequence(s)
      AC122870, AC129294, AC134448, AC161425
      Consensus CDS
      CCDS17394.1
      UniProtKB/Swiss-Prot
      Q3TF06, Q9DBU6
      UniProtKB/TrEMBL
      Q80XR9
      Related
      ENSMUSP00000066797.8, ENSMUST00000065074.14

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      66888694..67265736
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036163232.1XP_036019125.1  serine/Arginine-related protein 53 isoform X5

    2. XM_017319694.3XP_017175183.1  serine/Arginine-related protein 53 isoform X1

      UniProtKB/TrEMBL
      Q9CSR8
    3. XM_036163231.1XP_036019124.1  serine/Arginine-related protein 53 isoform X3

    4. XM_017319692.3XP_017175181.1  serine/Arginine-related protein 53 isoform X1

      UniProtKB/TrEMBL
      Q9CSR8
    5. XM_006501911.5XP_006501974.1  serine/Arginine-related protein 53 isoform X4

    6. XM_006501913.5XP_006501976.1  serine/Arginine-related protein 53 isoform X5

    7. XM_011240198.3XP_011238500.2  serine/Arginine-related protein 53 isoform X2

      Conserved Domains (1) summary
      pfam18697
      Location:139216
      MLVIN_C; Murine leukemia virus (MLV) integrase (IN) C-terminal domain
    8. XM_017319693.3XP_017175182.1  serine/Arginine-related protein 53 isoform X1

      UniProtKB/TrEMBL
      Q9CSR8