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    Nubp1 NUBP iron-sulfur cluster assembly factor 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 287042, updated on 27-Nov-2024

    Summary

    Official Symbol
    Nubp1provided by RGD
    Official Full Name
    NUBP iron-sulfur cluster assembly factor 1provided by RGD
    Primary source
    RGD:1310514
    See related
    EnsemblRapid:ENSRNOG00000077863 AllianceGenome:RGD:1310514
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable iron-sulfur cluster binding activity. Predicted to be involved in intracellular iron ion homeostasis; iron-sulfur cluster assembly; and regulation of cell growth. Predicted to act upstream of or within centrosome localization; negative regulation of centrosome duplication; and protein localization to cell cortex. Predicted to be located in plasma membrane. Predicted to be active in cytosol. Orthologous to human NUBP1 (NUBP iron-sulfur cluster assembly factor 1, cytosolic). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 206.4), Kidney (RPKM 204.1) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Nubp1 in Genome Data Viewer
    Location:
    10q11
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (5766157..5777648, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (5259328..5270848, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (5333378..5343949, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene CCHC-type zinc finger, nucleic acid binding protein, pseudogene 2 Neighboring gene uncharacterized LOC134480647 Neighboring gene trans-golgi network vesicle protein 23 homolog A Neighboring gene uncharacterized LOC102553451 Neighboring gene tektin 5

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Clone Names

    • MGC108970

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 4 iron, 4 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP-dependent FeS chaperone activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables iron-sulfur cluster binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables iron-sulfur cluster binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables iron-sulfur cluster binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in cell projection organization IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within centrosome localization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intracellular iron ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in iron-sulfur cluster assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in iron-sulfur cluster assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in iron-sulfur cluster assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within negative regulation of centrosome duplication ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within protein localization to cell cortex ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in centriole IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cilium IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    cytosolic Fe-S cluster assembly factor NUBP1
    Names
    NBP 1
    nucleotide binding protein 1 (MinD homolog, E. coli)
    nucleotide-binding protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001009619.2NP_001009619.1  cytosolic Fe-S cluster assembly factor NUBP1

      See identical proteins and their annotated locations for NP_001009619.1

      Status: VALIDATED

      Source sequence(s)
      FQ136567, FQ144533, FQ214074, FQ229330, JAXUCZ010000010
      UniProtKB/Swiss-Prot
      Q5I0L4
      UniProtKB/TrEMBL
      A6K4K2
      Related
      ENSRNOP00000105084.1, ENSRNOT00000134135.1
      Conserved Domains (1) summary
      pfam10609
      Location:53303
      ParA; NUBPL iron-transfer P-loop NTPase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      5766157..5777648 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)