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    Spo11 SPO11 initiator of meiotic double strand breaks [ Rattus norvegicus (Norway rat) ]

    Gene ID: 366261, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Spo11provided by RGD
    Official Full Name
    SPO11 initiator of meiotic double strand breaksprovided by RGD
    Primary source
    RGD:1306454
    See related
    EnsemblRapid:ENSRNOG00000006732 AllianceGenome:RGD:1306454
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable DNA binding activity. Predicted to be involved in meiotic DNA double-strand break formation; meiotic DNA double-strand break processing; and reciprocal meiotic recombination. Predicted to act upstream of or within several processes, including germ cell development; meiosis I; and ovarian follicle development. Predicted to be located in chromosome, telomeric region. Predicted to be active in nuclear chromosome. Orthologous to human SPO11 (SPO11 initiator of meiotic double strand breaks). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 84.8), Kidney (RPKM 27.9) and 2 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Spo11 in Genome Data Viewer
    Location:
    3q42
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (182173615..182189273)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (161755299..161770930)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (170991573..171008226)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486499 Neighboring gene bone morphogenetic protein 7 Neighboring gene uncharacterized LOC134486500 Neighboring gene ribonucleic acid export 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Crossover and noncrossover pathways in mouse meiosis. Guillon H, et al. Mol Cell, 2005 Nov 23. PMID 16307920
    2. Zscan4 regulates telomere elongation and genomic stability in ES cells. Zalzman M, et al. Nature, 2010 Apr 8. PMID 20336070, Free PMC Article
    3. Distinct DNA-damage-dependent and -independent responses drive the loss of oocytes in recombination-defective mouse mutants. Di Giacomo M, et al. Proc Natl Acad Sci U S A, 2005 Jan 18. PMID 15640358, Free PMC Article
    4. Mouse maelstrom, a component of nuage, is essential for spermatogenesis and transposon repression in meiosis. Soper SF, et al. Dev Cell, 2008 Aug. PMID 18694567, Free PMC Article
    5. Meiosis-specific cohesin mediates homolog recognition in mouse spermatocytes. Ishiguro K, et al. Genes Dev, 2014 Mar 15. PMID 24589552, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within double-strand break repair involved in meiotic recombination ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within homologous chromosome pairing at meiosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within male meiosis I ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in meiotic DNA double-strand break formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in meiotic DNA double-strand break processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within meiotic telomere clustering ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within oogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within ovarian follicle development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein localization to chromosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in reciprocal meiotic recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within reciprocal meiotic recombination ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within spermatid development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within synaptonemal complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in chromosome, telomeric region ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nuclear chromosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    meiotic recombination protein SPO11
    Names
    SPO11 meiotic protein covalently bound to DSB homolog
    SPO11, initiator of meiotic double stranded breaks
    sporulation protein, meiosis-specific, SPO11 homolog
    NP_001402745.1
    XP_038961537.1
    XP_038961538.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001415816.1 → NP_001402745.1  meiotic recombination protein SPO11

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      D3Z8A8
      Related
      ENSRNOP00000008959.4, ENSRNOT00000008959.6

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      182173615..182189273
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039105610.2 → XP_038961538.1  meiotic recombination protein SPO11 isoform X2

      UniProtKB/TrEMBL
      A6KKY2
      Conserved Domains (1) summary
      COG1697
      Location:29 → 280
      Spo11; DNA topoisomerase VI, subunit A [Replication, recombination and repair]

    2. XM_039105609.2 → XP_038961537.1  meiotic recombination protein SPO11 isoform X1

      Conserved Domains (2) summary
      COG1697
      Location:43 → 360
      Spo11; DNA topoisomerase VI, subunit A [Replication, recombination and repair]
      pfam03533
      Location:2 → 44
      SPO11_like; SPO11 homolog

    RNA

    1. XR_005501952.2 RNA Sequence

    2. XR_005501951.2 RNA Sequence

    3. XR_005501953.2 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001108964.1: Suppressed sequence

      Description
      NM_001108964.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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