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    Kansl3 KAT8 regulatory NSL complex subunit 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 316328, updated on 9-Dec-2024

    Summary

    Official Symbol
    Kansl3provided by RGD
    Official Full Name
    KAT8 regulatory NSL complex subunit 3provided by RGD
    Primary source
    RGD:1309220
    See related
    EnsemblRapid:ENSRNOG00000015417 AllianceGenome:RGD:1309220
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1309220
    Summary
    Predicted to be involved in positive regulation of transcription by RNA polymerase II and regulation of mitochondrial transcription. Predicted to be located in mitochondrion and nucleoplasm. Predicted to be part of NSL complex. Orthologous to human KANSL3 (KAT8 regulatory NSL complex subunit 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 155.5), Testes (RPKM 130.7) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Kansl3 in Genome Data Viewer
    Location:
    9q21
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (46058070..46101643, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (38562170..38605757, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (42899432..42943224, complement)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100909803 Neighboring gene uncharacterized LOC102554222 Neighboring gene neuralized E3 ubiquitin protein ligase 3 Neighboring gene AT-rich interaction domain 5A Neighboring gene fer-1-like family member 5 Neighboring gene lectin, mannose-binding 2-like

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in chromatin organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of mitochondrial transcription IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of mitochondrial transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of mitochondrial transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    part_of NSL complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of NSL complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of NSL complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of NSL complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of histone acetyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of histone acetyltransferase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    KAT8 regulatory NSL complex subunit 3
    Names
    NSL complex protein NSL3
    non-specific lethal 3 homolog

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001034835.1NP_001030007.1  KAT8 regulatory NSL complex subunit 3

      See identical proteins and their annotated locations for NP_001030007.1

      Status: PROVISIONAL

      Source sequence(s)
      BC105865
      UniProtKB/Swiss-Prot
      Q3KR73
      UniProtKB/TrEMBL
      A0A0G2K522
      Related
      ENSRNOP00000099135.1, ENSRNOT00000124022.1
      Conserved Domains (1) summary
      pfam12695
      Location:342436
      Abhydrolase_5; Alpha/beta hydrolase family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      46058070..46101643 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039083566.2XP_038939494.1  KAT8 regulatory NSL complex subunit 3 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K522, A0A8L2QAX1
    2. XM_006244808.5XP_006244870.1  KAT8 regulatory NSL complex subunit 3 isoform X1

      See identical proteins and their annotated locations for XP_006244870.1

      UniProtKB/TrEMBL
      A0A0G2K522, A0A8L2QAX1
      Related
      ENSRNOP00000020955.6, ENSRNOT00000020955.7
      Conserved Domains (1) summary
      pfam12695
      Location:342436
      Abhydrolase_5; Alpha/beta hydrolase family
    3. XM_063267150.1XP_063123220.1  KAT8 regulatory NSL complex subunit 3 isoform X2

      UniProtKB/Swiss-Prot
      Q3KR73
      UniProtKB/TrEMBL
      A0A0G2K522
    4. XM_039083567.2XP_038939495.1  KAT8 regulatory NSL complex subunit 3 isoform X3

      UniProtKB/TrEMBL
      A0A0G2K522
    5. XM_063267149.1XP_063123219.1  KAT8 regulatory NSL complex subunit 3 isoform X2

      UniProtKB/Swiss-Prot
      Q3KR73
      UniProtKB/TrEMBL
      A0A0G2K522
    6. XM_006244809.5XP_006244871.1  KAT8 regulatory NSL complex subunit 3 isoform X1

      See identical proteins and their annotated locations for XP_006244871.1

      UniProtKB/TrEMBL
      A0A0G2K522, A0A8L2QAX1
      Conserved Domains (1) summary
      pfam12695
      Location:342436
      Abhydrolase_5; Alpha/beta hydrolase family
    7. XM_063267151.1XP_063123221.1  KAT8 regulatory NSL complex subunit 3 isoform X2

      UniProtKB/Swiss-Prot
      Q3KR73
      UniProtKB/TrEMBL
      A0A0G2K522
    8. XM_006244810.5XP_006244872.1  KAT8 regulatory NSL complex subunit 3 isoform X1

      See identical proteins and their annotated locations for XP_006244872.1

      UniProtKB/TrEMBL
      A0A0G2K522, A0A8L2QAX1
      Conserved Domains (1) summary
      pfam12695
      Location:342436
      Abhydrolase_5; Alpha/beta hydrolase family
    9. XM_063267147.1XP_063123217.1  KAT8 regulatory NSL complex subunit 3 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K522, A0A8L2QAX1
    10. XM_006244811.3XP_006244873.1  KAT8 regulatory NSL complex subunit 3 isoform X3

      See identical proteins and their annotated locations for XP_006244873.1

      UniProtKB/TrEMBL
      A0A0G2K522
      Conserved Domains (1) summary
      pfam12695
      Location:243337
      Abhydrolase_5; Alpha/beta hydrolase family
    11. XM_063267152.1XP_063123222.1  KAT8 regulatory NSL complex subunit 3 isoform X2

      UniProtKB/Swiss-Prot
      Q3KR73
      UniProtKB/TrEMBL
      A0A0G2K522
    12. XM_006244812.4XP_006244874.1  KAT8 regulatory NSL complex subunit 3 isoform X3

      See identical proteins and their annotated locations for XP_006244874.1

      UniProtKB/TrEMBL
      A0A0G2K522
      Conserved Domains (1) summary
      pfam12695
      Location:243337
      Abhydrolase_5; Alpha/beta hydrolase family
    13. XM_063267154.1XP_063123224.1  KAT8 regulatory NSL complex subunit 3 isoform X5

      UniProtKB/TrEMBL
      A0A0G2K522
    14. XM_063267153.1XP_063123223.1  KAT8 regulatory NSL complex subunit 3 isoform X4

      UniProtKB/TrEMBL
      A0A0G2K522
      Related
      ENSRNOP00000073261.3, ENSRNOT00000085260.3
    15. XM_039083569.2XP_038939497.1  KAT8 regulatory NSL complex subunit 3 isoform X6