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    RHOXF1 Rhox homeobox family member 1 [ Homo sapiens (human) ]

    Gene ID: 158800, updated on 10-Dec-2024

    Summary

    Official Symbol
    RHOXF1provided by HGNC
    Official Full Name
    Rhox homeobox family member 1provided by HGNC
    Primary source
    HGNC:HGNC:29993
    See related
    Ensembl:ENSG00000101883 MIM:300446; AllianceGenome:HGNC:29993
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    OTEX; PEPP1
    Summary
    This gene is a member of the PEPP subfamily of paired-like homoebox genes. The gene may be regulated by androgens and epigenetic mechanisms. The encoded nuclear protein is likely a transcription factor that may play a role in human reproduction. [provided by RefSeq, Dec 2012]
    Expression
    Biased expression in testis (RPKM 4.9), fat (RPKM 1.1) and 2 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See RHOXF1 in Genome Data Viewer
    Location:
    Xq24
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (120109051..120120438, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (118484211..118495405, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (119243009..119249823, complement)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene ReSE screen-validated silencer GRCh37_chrX:119148782-119148953 Neighboring gene Rhox homeobox family member 1 pseudogene 1 Neighboring gene RHOXF1 antisense RNA 1 Neighboring gene NANOG hESC enhancer GRCh37_chrX:119177771-119178272 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:119185571-119186072 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:119186073-119186572 Neighboring gene Rhox homeobox family member 2B Neighboring gene ReSE screen-validated silencer GRCh37_chrX:119254442-119254623 Neighboring gene long intergenic non-protein coding RNA 1402 Neighboring gene Rhox homeobox family member 2 Neighboring gene SFR1 pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC119030, MGC119033

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in androgen receptor signaling pathway IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
     
    involved_in regulation of DNA-templated transcription NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in chromatin ISA
    Inferred from Sequence Alignment
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    rhox homeobox family member 1
    Names
    PEPP subfamily gene 1
    ovary-, testis- and epididymis-expressed gene protein
    paired-like homeobox protein PEPP-1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_139282.3NP_644811.1  rhox homeobox family member 1

      See identical proteins and their annotated locations for NP_644811.1

      Status: REVIEWED

      Source sequence(s)
      AC240732, AY099086, BE675048
      Consensus CDS
      CCDS14593.1
      UniProtKB/Swiss-Prot
      O95030, Q3SYE0, Q8NHV9
      Related
      ENSP00000217999.1, ENST00000217999.3
      Conserved Domains (1) summary
      cd00086
      Location:104162
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      120109051..120120438 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011531281.3XP_011529583.1  rhox homeobox family member 1 isoform X1

      Conserved Domains (1) summary
      cd00086
      Location:132190
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      118484211..118495405 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054326545.1XP_054182520.1  rhox homeobox family member 1 isoform X1