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    ADAMTS15 ADAM metallopeptidase with thrombospondin type 1 motif 15 [ Homo sapiens (human) ]

    Gene ID: 170689, updated on 10-Dec-2024

    Summary

    Official Symbol
    ADAMTS15provided by HGNC
    Official Full Name
    ADAM metallopeptidase with thrombospondin type 1 motif 15provided by HGNC
    Primary source
    HGNC:HGNC:16305
    See related
    Ensembl:ENSG00000166106 MIM:607509; AllianceGenome:HGNC:16305
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DA12
    Summary
    This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme, which may play a role in versican processing during skeletal muscle development. This gene may function as a tumor suppressor in colorectal and breast cancers. [provided by RefSeq, May 2016]
    Expression
    Biased expression in fat (RPKM 10.9), placenta (RPKM 8.5) and 13 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See ADAMTS15 in Genome Data Viewer
    Location:
    11q24.3
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (130448645..130476645)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (130484367..130513939)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (130318540..130346540)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4080 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5754 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5755 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4081 Neighboring gene ZBTB44 divergent transcript Neighboring gene NANOG hESC enhancer GRCh37_chr11:130240792-130241293 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr11:130248135-130248650 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr11:130253373-130253917 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:130289647-130290148 Neighboring gene ADAM metallopeptidase with thrombospondin type 1 motif 8 Neighboring gene NANOG hESC enhancer GRCh37_chr11:130321509-130322010 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr11:130347582-130348781 Neighboring gene NANOG hESC enhancer GRCh37_chr11:130378843-130379344 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr11:130381109-130382308 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr11:130386937-130387456 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:130389783-130390284 Neighboring gene uncharacterized LOC105369574 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:130392807-130393434 Neighboring gene MPRA-validated peak1516 silencer Neighboring gene BCL2 antagonist/killer 1 pseudogene 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Arthrogryposis, distal, type 12
    MedGen: C5882704 OMIM: 620545 GeneReviews: Not available
    not available

    EBI GWAS Catalog

    Description
    Genome-wide association study of chronic periodontitis in a general German population.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC126403

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables endopeptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables extracellular matrix binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables heparin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in extracellular matrix disassembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in extracellular matrix organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in myoblast fusion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cell surface IEA
    Inferred from Electronic Annotation
    more info
     
    located_in collagen-containing extracellular matrix IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    A disintegrin and metalloproteinase with thrombospondin motifs 15
    Names
    a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 15, preproprotein
    metalloprotease disintegrin 15 with thrombospondin domains

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_139055.4NP_620686.1  A disintegrin and metalloproteinase with thrombospondin motifs 15 preproprotein

      See identical proteins and their annotated locations for NP_620686.1

      Status: REVIEWED

      Source sequence(s)
      AP002986, AP003459
      Consensus CDS
      CCDS8488.1
      UniProtKB/Swiss-Prot
      Q32MI6, Q8TE58
      Related
      ENSP00000299164.2, ENST00000299164.4
      Conserved Domains (5) summary
      smart00209
      Location:519571
      TSP1; Thrombospondin type 1 repeats
      cd04273
      Location:218424
      ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
      pfam01562
      Location:24142
      Pep_M12B_propep; Reprolysin family propeptide
      pfam05986
      Location:683801
      ADAM_spacer1; ADAM-TS Spacer 1
      cl15456
      Location:437506
      ADAM_CR; ADAM cysteine-rich

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      130448645..130476645
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005271419.5XP_005271476.1  A disintegrin and metalloproteinase with thrombospondin motifs 15 isoform X1

      Conserved Domains (4) summary
      smart00209
      Location:188240
      TSP1; Thrombospondin type 1 repeats
      pfam05986
      Location:352470
      ADAM_spacer1; ADAM-TS Spacer 1
      cl00064
      Location:193
      ZnMc; Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which ...
      cl15456
      Location:106175
      ADAM_CR; ADAM cysteine-rich

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      130484367..130513939
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054367887.1XP_054223862.1  A disintegrin and metalloproteinase with thrombospondin motifs 15 isoform X1

    RNA

    1. XR_008488351.1 RNA Sequence