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    TMEM178B transmembrane protein 178B [ Homo sapiens (human) ]

    Gene ID: 100507421, updated on 10-Dec-2024

    Summary

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    Official Symbol
    TMEM178Bprovided by HGNC
    Official Full Name
    transmembrane protein 178Bprovided by HGNC
    Primary source
    HGNC:HGNC:44112
    See related
    Ensembl:ENSG00000261115 AllianceGenome:HGNC:44112
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to be active in membrane. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in brain (RPKM 6.9), thyroid (RPKM 5.0) and 9 other tissues See more
    Orthologs
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    Genomic context

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    See TMEM178B in Genome Data Viewer
    Location:
    7q34
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (141074064..141511296)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (142388269..142827078)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (140773864..141180180)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986719 Neighboring gene uncharacterized LOC105375537 Neighboring gene NANOG hESC enhancer GRCh37_chr7:140757357-140757858 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:140766919-140767513 Neighboring gene MPRA-validated peak6794 silencer Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr7:140858131-140859330 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:140900487-140901012 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26788 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:141041782-141041989 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:141063037-141063826 Neighboring gene uncharacterized LOC124901760 Neighboring gene NADH:ubiquinone oxidoreductase subunit B10 pseudogene 2 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:141129896-141130404 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:141130405-141130913 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr7:141181561-141182760 Neighboring gene NANOG hESC enhancer GRCh37_chr7:141184837-141185338 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:141190238-141190791 Neighboring gene MPRA-validated peak6797 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18717 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18718 Neighboring gene AGK divergent transcript Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:141284163-141284720 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr7:141284721-141285276 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:141285835-141286391 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr7:141286949-141287505 Neighboring gene acylglycerol kinase Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:141374567-141375546 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:141391618-141392127 Neighboring gene DENN domain containing 11

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Tmem178 negatively regulates store-operated calcium entry in myeloid cells via association with STIM1. Yang Z, et al. J Autoimmun, 2019 Jul. PMID 31018906, Free PMC Article
    2. Oncogenic BRAF fusions in mucosal melanomas activate the MAPK pathway and are sensitive to MEK/PI3K inhibition or MEK/CDK4/6 inhibition. Kim HS, et al. Oncogene, 2017 Jun 8. PMID 28092667
    3. Tmem178 Negatively Regulates IL-1β Production Through Inhibition of the NLRP3 Inflammasome. Khanna K, et al. Arthritis Rheumatol, 2024 Jan. PMID 37534578,
    4. Genome-wide association study of primary dentition pit-and-fissure and smooth surface caries. Zeng Z, et al. Caries Res, 2014. PMID 24556642, Free PMC Article
    5. A protein-protein interaction map of the TNF-induced NF-κB signal transduction pathway. Van Quickelberghe E, et al. Sci Data, 2018 Dec 18. PMID 30561431, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Tmem178 Negatively Regulates IL-1beta Production Through Inhibition of the NLRP3 Inflammasome.
      Title: Tmem178 Negatively Regulates IL-1β Production Through Inhibition of the NLRP3 Inflammasome.
    2. Tmem178 modulates the rate-limiting step of STIM1 puncta formation and therefore controls SOCE in inflammatory conditions.
      Title: Tmem178 negatively regulates store-operated calcium entry in myeloid cells via association with STIM1.
    3. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association study of primary dentition pit-and-fissure and smooth surface caries.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ39162, FLJ42883, DKFZp547G036

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane protein 178B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001195278.2 → NP_001182207.1  transmembrane protein 178B precursor

      See identical proteins and their annotated locations for NP_001182207.1

      Status: VALIDATED

      Source sequence(s)
      AC005692, AC006362, AC006396, AC073878
      Consensus CDS
      CCDS59086.1
      UniProtKB/Swiss-Prot
      H3BS89
      Related
      ENSP00000456594.1, ENST00000565468.6
      Conserved Domains (1) summary
      cl21598
      Location:100 → 266
      PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      141074064..141511296
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017011636.2 → XP_016867125.1  transmembrane protein 178B isoform X2

    2. XM_011515705.3 → XP_011514007.1  transmembrane protein 178B isoform X1

      Conserved Domains (1) summary
      cl21598
      Location:104 → 218
      PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

    RNA

    1. XR_001744505.2 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      142388269..142827078
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054356978.1 → XP_054212953.1  transmembrane protein 178B isoform X2

    2. XM_054356977.1 → XP_054212952.1  transmembrane protein 178B isoform X1

    RNA

    1. XR_008487517.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    H3BS89.1 GenPept UniProtKB/Swiss-Prot:H3BS89

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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