U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    NEDD4L NEDD4 like E3 ubiquitin protein ligase [ Homo sapiens (human) ]

    Gene ID: 23327, updated on 27-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    NEDD4Lprovided by HGNC
    Official Full Name
    NEDD4 like E3 ubiquitin protein ligaseprovided by HGNC
    Primary source
    HGNC:HGNC:7728
    See related
    Ensembl:ENSG00000049759 MIM:606384; AllianceGenome:HGNC:7728
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RSP5; PVNH7; NEDD4-2; NEDD4.2; hNEDD4-2
    Summary
    This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein mediates the ubiquitination of multiple target substrates and plays a critical role in epithelial sodium transport by regulating the cell surface expression of the epithelial sodium channel, ENaC. Single nucleotide polymorphisms in this gene may be associated with essential hypertension. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]
    Expression
    Broad expression in prostate (RPKM 13.1), kidney (RPKM 13.0) and 25 other tissues See more
    Orthologs
    mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See NEDD4L in Genome Data Viewer
    Location:
    18q21.31
    Exon count:
    43
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (58044226..58401540)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (58244126..58602300)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (55711458..56068772)

    Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1897 Neighboring gene Sharpr-MPRA regulatory region 3246 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13381 Neighboring gene CRISPRi-validated cis-regulatory element chr18.1280 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9482 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9483 Neighboring gene high mobility group nucleosome binding domain 1 pseudogene 30 Neighboring gene NANOG hESC enhancer GRCh37_chr18:55747705-55748297 Neighboring gene Sharpr-MPRA regulatory region 539 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13382 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13383 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:55793171-55793670 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:55838061-55838872 Neighboring gene uncharacterized LOC105372143 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:55862243-55862765 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:55862766-55863287 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13384 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:55890569-55891162 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13385 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13386 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:55914788-55915293 Neighboring gene ReSE screen-validated silencer GRCh37_chr18:55977766-55977988 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr18:55982687-55983886 Neighboring gene Sharpr-MPRA regulatory region 8690 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13387 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:56045193-56045729 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:56045730-56046265 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:56059391-56059890 Neighboring gene MIR122 host gene Neighboring gene H3K27ac hESC enhancer GRCh37_chr18:56160423-56160924 Neighboring gene H3K27ac hESC enhancer GRCh37_chr18:56160925-56161424 Neighboring gene microRNA 3591 Neighboring gene microRNA 122 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr18:56178733-56179504 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr18:56179505-56180274 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13388 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9486 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13389 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13390 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr18:56202574-56203773 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13394 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13395 Neighboring gene alpha kinase 2 Neighboring gene uncharacterized LOC105372145 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13396 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13397

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Decreased expression of Nedd4L correlates with poor prognosis in gastric cancer patient. Gao C, et al. Med Oncol, 2012 Sep. PMID 21909941
    2. Gender flip-flop association between genetic variations of NEDD4L and metabolic syndrome in the Kazakh general population. Wang HM, et al. Genet Mol Res, 2014 Jan 8. PMID 24446284
    3. Pathobiological properties of the ubiquitin ligase Nedd4L in melanoma. Kito Y, et al. Int J Exp Pathol, 2014 Feb. PMID 24456330, Free PMC Article
    4. Expression, transcription, and possible antagonistic interaction of the human Nedd4L gene variant: implications for essential hypertension. Araki N, et al. Hypertension, 2008 Mar. PMID 18268134
    5. The phosphorylation of endogenous Nedd4-2 In Na(+)-absorbing human airway epithelial cells. Ismail NA, et al. Eur J Pharmacol, 2014 Jun 5. PMID 24657276, Free PMC Article

    See all (375) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. NEDD4L-mediated RASGRP2 suppresses high-glucose and oxLDL-induced vascular endothelial cell dysfunctions by activating Rap1 and R-Ras.
      Title: NEDD4L-mediated RASGRP2 suppresses high-glucose and oxLDL-induced vascular endothelial cell dysfunctions by activating Rap1 and R-Ras.
    2. E3 Ubiquitin Ligase NEDD4L Negatively Regulates Skin Tumorigenesis by Inhibiting IL-6/GP130 Signaling Pathway.
      Title: E3 Ubiquitin Ligase NEDD4L Negatively Regulates Skin Tumorigenesis by Inhibiting IL-6/GP130 Signaling Pathway.
    3. Ubiquitination of angiotensin-converting enzyme 2 contributes to the development of pulmonary arterial hypertension mediated by neural precursor cell-expressed developmentally down-regulated gene 4-Like.
      Title: Ubiquitination of angiotensin-converting enzyme 2 contributes to the development of pulmonary arterial hypertension mediated by neural precursor cell-expressed developmentally down-regulated gene 4-Like.
    4. Aberrant expression of NEDD4L disrupts mitochondrial homeostasis by downregulating CaMKKbeta in diabetic kidney disease.
      Title: Aberrant expression of NEDD4L disrupts mitochondrial homeostasis by downregulating CaMKKβ in diabetic kidney disease.
    5. NEDD4L mediates ITGB4 ubiquitination and degradation to suppress esophageal carcinoma progression.
      Title: NEDD4L mediates ITGB4 ubiquitination and degradation to suppress esophageal carcinoma progression.
    6. NEDD4L intramolecular interactions regulate its auto and substrate NaV1.5 ubiquitination.
      Title: NEDD4L intramolecular interactions regulate its auto and substrate Na(V)1.5 ubiquitination.
    7. NEDD4L is a promoter for angiogenesis and cell proliferation in human umbilical vein endothelial cells.
      Title: NEDD4L is a promoter for angiogenesis and cell proliferation in human umbilical vein endothelial cells.
    8. METTL3 regulates TFRC ubiquitination and ferroptosis through stabilizing NEDD4L mRNA to impact stroke.
      Title: METTL3 regulates TFRC ubiquitination and ferroptosis through stabilizing NEDD4L mRNA to impact stroke.
    9. Investigation of the Binding Interaction of Mfsd2a with NEDD4-2 via Molecular Dynamics Simulations.
      Title: Investigation of the Binding Interaction of Mfsd2a with NEDD4-2 via Molecular Dynamics Simulations.
    10. Physiological Functions of the Ubiquitin Ligases Nedd4-1 and Nedd4-2.
      Title: Physiological Functions of the Ubiquitin Ligases Nedd4-1 and Nedd4-2.
    Submit: New GeneRIF Correction See all GeneRIFs (149)

    Phenotypes

    Go to the top of the page Help

    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Periventricular nodular heterotopia 7
    MedGen: C4310669 OMIM: 617201 GeneReviews: Not available
    		Compare labs

    EBI GWAS Catalog

    Description
    A genome-wide association study of caffeine-related sleep disturbance: confirmation of a role for a common variant in the adenosine receptor.
    EBI GWAS Catalog
    Genome-wide association study combining pathway analysis for typical sporadic amyotrophic lateral sclerosis in Chinese Han populations.
    EBI GWAS Catalog
    Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.
    EBI GWAS Catalog
    Genome-wide association study of d-amphetamine response in healthy volunteers identifies putative associations, including cadherin 13 (CDH13).
    EBI GWAS Catalog
    Genome-wide meta-analysis identifies new susceptibility loci for migraine.
    EBI GWAS Catalog

    Variation

    Go to the top of the page Help

    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

    Go to the top of the page Help

    Replication interactions

    Interaction Pubs
    HIV-1 replication is enhanced by CIT expression, which is dependent on NEDD4L expression as shown through siRNA knockdown of NEDD4L PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Pr55(Gag) gag Angiomotin (AMOT) stimulates NEDD4L-dependent release of HIV-1 Gag delta PTAP/YP in a does-dependent manner in 293T cells PubMed
    gag Angiomotin (AMOT), AMOT-like protein 1, and AMOT-like protein 2 bind directly and specifically to NEDD4L and HIV-1 Gag-delta p6 in protein pull-down experiments PubMed
    gag The residual C2 domain (residues 1-31) of NEDD4-2s confers the ability to associate with HIV-1 Gag and to rescue HIV-1delta(PTAPP) budding PubMed
    gag Targeting of the catalytic HECT domain (residues 598-952) of NEDD4-2s to HIV-1 Gag via CypA is sufficient to rescue HIV-1 budding defects PubMed
    Vpr vpr HIV-1 Vpr is identified to have a physical interaction with neural precursor cell expressed, developmentally down-regulated 4-like (NEDD4L) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
    nucleocapsid gag Mutations in the basic residues of the nucleocapsid domain of Gag cause severe defects in HIV-1 release, and overexpression of Nedd4.2 rescues NC mutant release defects PubMed
    p6 gag The residual C2-domain (amino acids 1-31) in NEDD4L is essential for the rescue of p6 late-domain mutants PubMed
    gag NEDD4L-mediated stimulation of virus budding is dependent upon the ubiquitin ligase activity of NEDD4L and requires only the minimal HIV-1 Gag assembly regions and TSG101 PubMed
    gag Overexpression of the HECT ubiquitin E3 ligase, NEDD4L/NEDD4-2 stimulates the release of HIV-1 constructs that lack TSG101- and ALIX-binding late domains in p6 PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Clone Names

    • FLJ33870, KIAA0439

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables potassium channel inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables potassium channel regulator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sodium channel inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sodium channel inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sodium channel regulator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transmembrane transporter binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ubiquitin-protein transferase activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables ubiquitin-protein transferase activity TAS
    Traceable Author Statement
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monoatomic ion transmembrane transport TAS
    Traceable Author Statement
    more info
    		  
    involved_in negative regulation of potassium ion transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of potassium ion transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of protein localization to cell surface IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of sodium ion import across plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of sodium ion transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of sodium ion transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in neuromuscular junction development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neuron projection development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of caveolin-mediated endocytosis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in positive regulation of dendrite extension IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein K48-linked ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein monoubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein ubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in receptor catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in receptor internalization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of dendrite morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of membrane depolarization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of membrane potential IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of membrane repolarization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of monoatomic ion transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of potassium ion transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of protein stability IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of sodium ion transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of synapse organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in ventricular cardiac muscle cell action potential ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in extracellular exosome HDA PubMed 
    located_in multivesicular body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    colocalizes_with plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    E3 ubiquitin-protein ligase NEDD4-like
    Names
    HECT-type E3 ubiquitin transferase NED4L
    neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
    ubiquitin-protein ligase Rsp5
    NP_001138436.1
    NP_001138437.1
    NP_001138438.1
    NP_001138439.1
    NP_001138440.1
    NP_001138441.1
    NP_001138442.1
    NP_001138443.1
    NP_001230889.1
    NP_056092.2
    XP_005266715.3
    XP_005266717.3
    XP_005266720.3
    XP_006722484.3
    XP_006722487.3
    XP_006722488.3
    XP_006722489.1
    XP_006722491.1
    XP_006722493.1
    XP_011524189.1
    XP_016881165.2
    XP_016881166.2
    XP_016881167.1
    XP_016881168.1
    XP_016881170.1
    XP_024306897.1
    XP_024306899.1
    XP_024306902.1
    XP_024306903.1
    XP_024306904.1
    XP_047293358.1
    XP_047293359.1
    XP_047293360.1
    XP_047293361.1
    XP_047293362.1
    XP_047293363.1
    XP_047293364.1
    XP_047293365.1
    XP_047293366.1
    XP_047293367.1
    XP_047293368.1
    XP_047293369.1
    XP_047293370.1
    XP_047293371.1
    XP_047293372.1
    XP_047293373.1
    XP_047293374.1
    XP_047293375.1
    XP_047293376.1
    XP_047293377.1
    XP_054174357.1
    XP_054174358.1
    XP_054174359.1
    XP_054174360.1
    XP_054174361.1
    XP_054174362.1
    XP_054174363.1
    XP_054174364.1
    XP_054174365.1
    XP_054174366.1
    XP_054174367.1
    XP_054174368.1
    XP_054174369.1
    XP_054174370.1
    XP_054174371.1
    XP_054174372.1
    XP_054174373.1
    XP_054174374.1
    XP_054174375.1
    XP_054174376.1
    XP_054174377.1
    XP_054174378.1
    XP_054174379.1
    XP_054174380.1
    XP_054174381.1
    XP_054174382.1
    XP_054174383.1
    XP_054174384.1
    XP_054174385.1
    XP_054174386.1
    XP_054174387.1
    XP_054174388.1
    XP_054174389.1
    XP_054174390.1
    XP_054174391.1
    XP_054174392.1
    XP_054174393.1
    XP_054174394.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029954.1 RefSeqGene

      Range
      4849..362162
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001144964.1 → NP_001138436.1  E3 ubiquitin-protein ligase NEDD4-like isoform 2

      See identical proteins and their annotated locations for NP_001138436.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (b) uses an alternate first exon, compared to variant j, which results in the use of a downstream in-frame start codon. The encoded protein (isoform 2) has a shorter N-terminus that lacks a C2 domain, compared to isoform 1. Variant b is also known as NEDD4-2C7. Variants a, b, and f encode the same isoform (2).
      Source sequence(s)
      AC090236, AF070601, AF385931, BC019345, BP260852, DA759940, DB317092
      Consensus CDS
      CCDS45875.1
      UniProtKB/TrEMBL
      B7Z6K0
      Related
      ENSP00000411947.1, ENST00000456986.5
      Conserved Domains (5) summary
      smart00456
      Location:428 → 460
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:521 → 850
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      PHA03247
      Location:198 → 381
      PHA03247; large tegument protein UL36; Provisional
      pfam00397
      Location:266 → 295
      WW; WW domain
      cl14603
      Location:1 → 32
      C2; C2 domain

    2. NM_001144965.2 → NP_001138437.1  E3 ubiquitin-protein ligase NEDD4-like isoform 2

      See identical proteins and their annotated locations for NP_001138437.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (f) uses an alternate first exon, compared to variant j, which results in the use of a downstream in-frame start codon. The encoded protein (isoform 2) has a shorter N-terminus that lacks a C2 domain, compared to isoform 1. Variants a, b, and f encode the same isoform (2).
      Source sequence(s)
      AC090236, AC107896, AY112983, BC032597
      Consensus CDS
      CCDS45875.1
      UniProtKB/TrEMBL
      B7Z6K0
      Conserved Domains (5) summary
      smart00456
      Location:428 → 460
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:521 → 850
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      PHA03247
      Location:198 → 381
      PHA03247; large tegument protein UL36; Provisional
      pfam00397
      Location:266 → 295
      WW; WW domain
      cl14603
      Location:1 → 32
      C2; C2 domain

    3. NM_001144966.3 → NP_001138438.1  E3 ubiquitin-protein ligase NEDD4-like isoform 2

      See identical proteins and their annotated locations for NP_001138438.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (a) uses an alternate first exon, compared to variant j, which results in the use of a downstream in-frame start codon. The encoded protein (isoform 2) has a shorter N-terminus that lacks a C2 domain, compared to isoform 1. Variant a is also known as NEDD4-2A. Variants a, b, and f encode the same isoform (2).
      Source sequence(s)
      AC090236, AF210730, AK300444, DC381911
      Consensus CDS
      CCDS45875.1
      UniProtKB/TrEMBL
      B7Z6K0
      Related
      ENSP00000389406.1, ENST00000431212.6
      Conserved Domains (5) summary
      smart00456
      Location:428 → 460
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:521 → 850
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      PHA03247
      Location:198 → 381
      PHA03247; large tegument protein UL36; Provisional
      pfam00397
      Location:266 → 295
      WW; WW domain
      cl14603
      Location:1 → 32
      C2; C2 domain

    4. NM_001144967.3 → NP_001138439.1  E3 ubiquitin-protein ligase NEDD4-like isoform 1

      See identical proteins and their annotated locations for NP_001138439.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (j) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC090236, AC107896, AY312514, BQ215431
      Consensus CDS
      CCDS45872.1
      UniProtKB/Swiss-Prot
      O43165, Q3LSM7, Q7Z5F1, Q7Z5F2, Q7Z5N3, Q8N5A7, Q8WUU9, Q96PU5, Q9BW58, Q9H2W4, Q9NT88
      UniProtKB/TrEMBL
      A0A6Q8PFI7
      Related
      ENSP00000383199.2, ENST00000400345.8
      Conserved Domains (5) summary
      cd04033
      Location:21 → 153
      C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)
      smart00456
      Location:549 → 581
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:642 → 971
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      PHA03247
      Location:319 → 502
      PHA03247; large tegument protein UL36; Provisional
      pfam00397
      Location:387 → 416
      WW; WW domain

    5. NM_001144968.2 → NP_001138440.1  E3 ubiquitin-protein ligase NEDD4-like isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (g) uses an alternate first exon, compared to variant j, which results in the use of a different start codon and a protein (isoform 4) with a shorter and distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AC090236, AC107896, AY112984, BC032597
      Consensus CDS
      CCDS45874.1
      UniProtKB/TrEMBL
      A0A6Q8PFI7
      Related
      ENSP00000350569.4, ENST00000357895.9
      Conserved Domains (6) summary
      cd04033
      Location:13 → 145
      C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)
      smart00456
      Location:541 → 573
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:634 → 963
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00201
      Location:492 → 522
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      pfam00397
      Location:379 → 408
      WW; WW domain
      cl26464
      Location:311 → 494
      Atrophin-1; Atrophin-1 family

    6. NM_001144969.2 → NP_001138441.1  E3 ubiquitin-protein ligase NEDD4-like isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (h) uses an alternate first exon and lacks a downstream in-frame exon, compared to variant j, which results in the use of a different start codon and a protein (isoform 5) with a shorter and distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AC090236, AC107896, AF070601, AY112985, BP260852, DA759940, DB317092, DQ181796
      Consensus CDS
      CCDS59323.1
      UniProtKB/TrEMBL
      A0A6Q8PFI7
      Related
      ENSP00000468546.1, ENST00000586263.5
      Conserved Domains (5) summary
      cd04033
      Location:13 → 145
      C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)
      smart00456
      Location:521 → 553
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:614 → 943
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00201
      Location:472 → 502
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      pfam00397
      Location:359 → 388
      WW; WW domain

    7. NM_001144970.3 → NP_001138442.1  E3 ubiquitin-protein ligase NEDD4-like isoform 6

      See identical proteins and their annotated locations for NP_001138442.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (c) uses an alternate first exon and lacks a downstream in-frame exon, compared to variant j. These differences result in the use of a downstream in-frame start codon and a protein (isoform 6) with a shorter N-terminus, compared to isoform 1. Variant c is also known as NEDD4-2B. Variants c and k encode the same isoform (6).
      Source sequence(s)
      AB007899, AC090236, AK294963, BC000621, DA819220
      Consensus CDS
      CCDS45876.1
      UniProtKB/TrEMBL
      B7Z2P9
      Related
      ENSP00000405440.1, ENST00000456173.6
      Conserved Domains (4) summary
      smart00456
      Location:408 → 440
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:501 → 830
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00397
      Location:246 → 275
      WW; WW domain
      cl14603
      Location:1 → 32
      C2; C2 domain

    8. NM_001144971.2 → NP_001138443.1  E3 ubiquitin-protein ligase NEDD4-like isoform 6

      See identical proteins and their annotated locations for NP_001138443.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (k) uses two alternate exons in its 5' end and lacks a downstream in-frame exon, compared to variant j. These differences result in the use of a downstream in-frame start codon and a protein (isoform 6) with a shorter N-terminus, compared to isoform 1. Variants c and k encode the same isoform (6).
      Source sequence(s)
      AC090236, AC107896, AF070601, BP260852, DA759940, DB317092, DQ181796
      Consensus CDS
      CCDS45876.1
      UniProtKB/TrEMBL
      B7Z2P9
      Related
      ENSP00000393395.1, ENST00000435432.6
      Conserved Domains (4) summary
      smart00456
      Location:408 → 440
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:501 → 830
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00397
      Location:246 → 275
      WW; WW domain
      cl14603
      Location:1 → 32
      C2; C2 domain

    9. NM_001243960.2 → NP_001230889.1  E3 ubiquitin-protein ligase NEDD4-like isoform 7

      See identical proteins and their annotated locations for NP_001230889.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (i) lacks two consecutive exons in the coding region, but maintains the reading frame, compared to variant j. The encoded isoform (7) is shorter than isoform 1.
      Source sequence(s)
      AC090236, AC107896, BC032597
      Consensus CDS
      CCDS58632.1
      UniProtKB/TrEMBL
      A0A6Q8PFI7
      Related
      ENSP00000348847.5, ENST00000356462.10
      Conserved Domains (5) summary
      cd04033
      Location:21 → 153
      C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)
      smart00456
      Location:485 → 517
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:578 → 907
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00201
      Location:436 → 466
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      pfam00397
      Location:198 → 224
      WW; WW domain

    10. NM_015277.6 → NP_056092.2  E3 ubiquitin-protein ligase NEDD4-like isoform 3

      See identical proteins and their annotated locations for NP_056092.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (d) lacks an in-frame exon, compared to variant j, resulting in a shorter protein (isoform 3), compared to isoform 1. Variant d is also known as NEDD4-2C6 and NEDL3.
      Source sequence(s)
      AB071179, AC090236, AC107896, BC000621
      Consensus CDS
      CCDS45873.1
      UniProtKB/TrEMBL
      A0A6Q8PFI7
      Related
      ENSP00000372301.3, ENST00000382850.8
      Conserved Domains (4) summary
      cd04033
      Location:21 → 153
      C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)
      smart00456
      Location:529 → 561
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:622 → 951
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00397
      Location:367 → 396
      WW; WW domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

      Range
      58044226..58401540
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006722426.5 → XP_006722489.1  E3 ubiquitin-protein ligase NEDD4-like isoform X11

      UniProtKB/TrEMBL
      A0A6Q8PFI7
      Conserved Domains (6) summary
      cd04033
      Location:21 → 179
      C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)
      smart00456
      Location:575 → 625
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:686 → 1015
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:662 → 1016
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd00201
      Location:526 → 556
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      pfam00397
      Location:413 → 442
      WW; WW domain

    2. XM_047437406.1 → XP_047293362.1  E3 ubiquitin-protein ligase NEDD4-like isoform X13

      UniProtKB/TrEMBL
      A0A6Q8PFI7

    3. XM_047437407.1 → XP_047293363.1  E3 ubiquitin-protein ligase NEDD4-like isoform X14

      UniProtKB/TrEMBL
      A0A6Q8PFI7

    4. XM_047437408.1 → XP_047293364.1  E3 ubiquitin-protein ligase NEDD4-like isoform X16

      UniProtKB/TrEMBL
      A0A6Q8PFI7

    5. XM_006722428.5 → XP_006722491.1  E3 ubiquitin-protein ligase NEDD4-like isoform X15

      UniProtKB/TrEMBL
      A0A6Q8PFI7
      Conserved Domains (6) summary
      cd04033
      Location:21 → 153
      C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)
      smart00456
      Location:549 → 599
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:660 → 989
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:636 → 990
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd00201
      Location:500 → 530
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      pfam00397
      Location:387 → 416
      WW; WW domain

    6. XM_017025678.3 → XP_016881167.1  E3 ubiquitin-protein ligase NEDD4-like isoform X18

      UniProtKB/TrEMBL
      A0A6Q8PFI7

    7. XM_047437421.1 → XP_047293377.1  E3 ubiquitin-protein ligase NEDD4-like isoform X24

      UniProtKB/TrEMBL
      A0A6Q8PG51

    8. XM_047437418.1 → XP_047293374.1  E3 ubiquitin-protein ligase NEDD4-like isoform X9

      UniProtKB/TrEMBL
      B7Z6K0

    9. XM_047437420.1 → XP_047293376.1  E3 ubiquitin-protein ligase NEDD4-like isoform X23

      UniProtKB/TrEMBL
      B7Z2P9

    10. XM_024451135.2 → XP_024306903.1  E3 ubiquitin-protein ligase NEDD4-like isoform X10

      UniProtKB/TrEMBL
      B7Z2P9
      Related
      ENSP00000502688.1, ENST00000675801.1
      Conserved Domains (4) summary
      smart00456
      Location:408 → 440
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:501 → 830
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00397
      Location:246 → 275
      WW; WW domain
      cl14603
      Location:1 → 32
      C2; C2 domain

    11. XM_047437419.1 → XP_047293375.1  E3 ubiquitin-protein ligase NEDD4-like isoform X9

      UniProtKB/TrEMBL
      B7Z6K0

    12. XM_047437417.1 → XP_047293373.1  E3 ubiquitin-protein ligase NEDD4-like isoform X9

      UniProtKB/TrEMBL
      B7Z6K0

    13. XM_024451136.2 → XP_024306904.1  E3 ubiquitin-protein ligase NEDD4-like isoform X10

      UniProtKB/TrEMBL
      B7Z2P9
      Conserved Domains (4) summary
      smart00456
      Location:408 → 440
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:501 → 830
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00397
      Location:246 → 275
      WW; WW domain
      cl14603
      Location:1 → 32
      C2; C2 domain

    14. XM_024451129.2 → XP_024306897.1  E3 ubiquitin-protein ligase NEDD4-like isoform X9

      UniProtKB/TrEMBL
      B7Z6K0
      Conserved Domains (5) summary
      smart00456
      Location:428 → 460
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:521 → 850
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      PHA03247
      Location:198 → 381
      PHA03247; large tegument protein UL36; Provisional
      pfam00397
      Location:266 → 295
      WW; WW domain
      cl14603
      Location:1 → 32
      C2; C2 domain

    15. XM_047437402.1 → XP_047293358.1  E3 ubiquitin-protein ligase NEDD4-like isoform X10

      UniProtKB/TrEMBL
      B7Z2P9

    16. XM_047437404.1 → XP_047293360.1  E3 ubiquitin-protein ligase NEDD4-like isoform X9

      UniProtKB/TrEMBL
      B7Z6K0

    17. XM_024451131.2 → XP_024306899.1  E3 ubiquitin-protein ligase NEDD4-like isoform X10

      UniProtKB/TrEMBL
      B7Z2P9
      Conserved Domains (4) summary
      smart00456
      Location:408 → 440
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:501 → 830
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00397
      Location:246 → 275
      WW; WW domain
      cl14603
      Location:1 → 32
      C2; C2 domain

    18. XM_047437409.1 → XP_047293365.1  E3 ubiquitin-protein ligase NEDD4-like isoform X17

      UniProtKB/TrEMBL
      A0A6Q8PFI7

    19. XM_047437410.1 → XP_047293366.1  E3 ubiquitin-protein ligase NEDD4-like isoform X19

      UniProtKB/TrEMBL
      A0A6Q8PFI7

    20. XM_047437403.1 → XP_047293359.1  E3 ubiquitin-protein ligase NEDD4-like isoform X9

      UniProtKB/TrEMBL
      B7Z6K0

    21. XM_047437405.1 → XP_047293361.1  E3 ubiquitin-protein ligase NEDD4-like isoform X10

      UniProtKB/TrEMBL
      B7Z2P9
      Related
      ENSP00000502428.1, ENST00000675502.1

    22. XM_024451134.2 → XP_024306902.1  E3 ubiquitin-protein ligase NEDD4-like isoform X22

      UniProtKB/TrEMBL
      B7Z6K0
      Conserved Domains (6) summary
      smart00456
      Location:428 → 478
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:539 → 868
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00201
      Location:379 → 409
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      pfam00397
      Location:266 → 295
      WW; WW domain
      cl14603
      Location:1 → 32
      C2; C2 domain
      cl26464
      Location:198 → 381
      Atrophin-1; Atrophin-1 family

    23. XM_047437414.1 → XP_047293370.1  E3 ubiquitin-protein ligase NEDD4-like isoform X22

      UniProtKB/TrEMBL
      B7Z6K0

    24. XM_011525887.4 → XP_011524189.1  E3 ubiquitin-protein ligase NEDD4-like isoform X12

      UniProtKB/TrEMBL
      A0A6Q8PFI7
      Conserved Domains (6) summary
      cd04033
      Location:13 → 171
      C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)
      smart00456
      Location:567 → 617
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:678 → 1007
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:654 → 1008
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd00201
      Location:518 → 548
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      pfam00397
      Location:405 → 434
      WW; WW domain

    25. XM_047437411.1 → XP_047293367.1  E3 ubiquitin-protein ligase NEDD4-like isoform X20

      UniProtKB/TrEMBL
      B7Z2P9

    26. XM_047437413.1 → XP_047293369.1  E3 ubiquitin-protein ligase NEDD4-like isoform X21

      UniProtKB/TrEMBL
      K7ERN1

    27. XM_047437412.1 → XP_047293368.1  E3 ubiquitin-protein ligase NEDD4-like isoform X20

      UniProtKB/TrEMBL
      B7Z2P9

    28. XM_006722430.5 → XP_006722493.1  E3 ubiquitin-protein ligase NEDD4-like isoform X22

      UniProtKB/TrEMBL
      B7Z6K0
      Conserved Domains (6) summary
      smart00456
      Location:428 → 478
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:539 → 868
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00201
      Location:379 → 409
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      pfam00397
      Location:266 → 295
      WW; WW domain
      cl14603
      Location:1 → 32
      C2; C2 domain
      cl26464
      Location:198 → 381
      Atrophin-1; Atrophin-1 family

    29. XM_017025679.3 → XP_016881168.1  E3 ubiquitin-protein ligase NEDD4-like isoform X9

      UniProtKB/TrEMBL
      B7Z6K0
      Conserved Domains (5) summary
      smart00456
      Location:428 → 460
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:521 → 850
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      PHA03247
      Location:198 → 381
      PHA03247; large tegument protein UL36; Provisional
      pfam00397
      Location:266 → 295
      WW; WW domain
      cl14603
      Location:1 → 32
      C2; C2 domain

    30. XM_017025681.3 → XP_016881170.1  E3 ubiquitin-protein ligase NEDD4-like isoform X21

      UniProtKB/TrEMBL
      K7ERN1
      Related
      ENSP00000468332.1, ENST00000587881.1

    31. XM_047437415.1 → XP_047293371.1  E3 ubiquitin-protein ligase NEDD4-like isoform X22

      UniProtKB/TrEMBL
      B7Z6K0

    32. XM_047437416.1 → XP_047293372.1  E3 ubiquitin-protein ligase NEDD4-like isoform X22

      UniProtKB/TrEMBL
      B7Z6K0

    33. XM_005266658.5 → XP_005266715.3  E3 ubiquitin-protein ligase NEDD4-like isoform X1

    34. XM_005266660.5 → XP_005266717.3  E3 ubiquitin-protein ligase NEDD4-like isoform X2

      UniProtKB/TrEMBL
      A0A1B0GVY1
      Related
      ENSP00000490696.1, ENST00000635997.1

    35. XM_006722421.5 → XP_006722484.3  E3 ubiquitin-protein ligase NEDD4-like isoform X3

    36. XM_005266663.5 → XP_005266720.3  E3 ubiquitin-protein ligase NEDD4-like isoform X4

    37. XM_017025676.2 → XP_016881165.2  E3 ubiquitin-protein ligase NEDD4-like isoform X5

    38. XM_017025677.2 → XP_016881166.2  E3 ubiquitin-protein ligase NEDD4-like isoform X6

    39. XM_006722424.4 → XP_006722487.3  E3 ubiquitin-protein ligase NEDD4-like isoform X7

    40. XM_006722425.4 → XP_006722488.3  E3 ubiquitin-protein ligase NEDD4-like isoform X8

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060942.1 Alternate T2T-CHM13v2.0

      Range
      58244126..58602300
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054318394.1 → XP_054174369.1  E3 ubiquitin-protein ligase NEDD4-like isoform X11

      UniProtKB/TrEMBL
      A0A6Q8PFI7

    2. XM_054318398.1 → XP_054174373.1  E3 ubiquitin-protein ligase NEDD4-like isoform X13

      UniProtKB/TrEMBL
      A0A6Q8PFI7

    3. XM_054318399.1 → XP_054174374.1  E3 ubiquitin-protein ligase NEDD4-like isoform X14

      UniProtKB/TrEMBL
      A0A6Q8PFI7

    4. XM_054318401.1 → XP_054174376.1  E3 ubiquitin-protein ligase NEDD4-like isoform X16

      UniProtKB/TrEMBL
      A0A6Q8PFI7

    5. XM_054318400.1 → XP_054174375.1  E3 ubiquitin-protein ligase NEDD4-like isoform X15

      UniProtKB/TrEMBL
      A0A6Q8PFI7

    6. XM_054318403.1 → XP_054174378.1  E3 ubiquitin-protein ligase NEDD4-like isoform X18

      UniProtKB/TrEMBL
      A0A6Q8PFI7

    7. XM_054318418.1 → XP_054174393.1  E3 ubiquitin-protein ligase NEDD4-like isoform X24

      UniProtKB/TrEMBL
      A0A6Q8PG51

    8. XM_054318412.1 → XP_054174387.1  E3 ubiquitin-protein ligase NEDD4-like isoform X9

      UniProtKB/TrEMBL
      B7Z6K0

    9. XM_054318416.1 → XP_054174391.1  E3 ubiquitin-protein ligase NEDD4-like isoform X10

      UniProtKB/TrEMBL
      B7Z2P9

    10. XM_054318417.1 → XP_054174392.1  E3 ubiquitin-protein ligase NEDD4-like isoform X10

      UniProtKB/TrEMBL
      B7Z2P9

    11. XM_054318415.1 → XP_054174390.1  E3 ubiquitin-protein ligase NEDD4-like isoform X23

      UniProtKB/TrEMBL
      B7Z2P9

    12. XM_054318413.1 → XP_054174388.1  E3 ubiquitin-protein ligase NEDD4-like isoform X9

      UniProtKB/TrEMBL
      B7Z6K0

    13. XM_054318414.1 → XP_054174389.1  E3 ubiquitin-protein ligase NEDD4-like isoform X9

      UniProtKB/TrEMBL
      B7Z6K0

    14. XM_054318390.1 → XP_054174365.1  E3 ubiquitin-protein ligase NEDD4-like isoform X9

      UniProtKB/TrEMBL
      B7Z6K0

    15. XM_054318393.1 → XP_054174368.1  E3 ubiquitin-protein ligase NEDD4-like isoform X9

      UniProtKB/TrEMBL
      B7Z6K0

    16. XM_054318397.1 → XP_054174372.1  E3 ubiquitin-protein ligase NEDD4-like isoform X10

      UniProtKB/TrEMBL
      B7Z2P9

    17. XM_054318391.1 → XP_054174366.1  E3 ubiquitin-protein ligase NEDD4-like isoform X10

      UniProtKB/TrEMBL
      B7Z2P9

    18. XM_054318402.1 → XP_054174377.1  E3 ubiquitin-protein ligase NEDD4-like isoform X17

      UniProtKB/TrEMBL
      A0A6Q8PFI7

    19. XM_054318404.1 → XP_054174379.1  E3 ubiquitin-protein ligase NEDD4-like isoform X19

      UniProtKB/TrEMBL
      A0A6Q8PFI7

    20. XM_054318392.1 → XP_054174367.1  E3 ubiquitin-protein ligase NEDD4-like isoform X9

      UniProtKB/TrEMBL
      B7Z6K0

    21. XM_054318396.1 → XP_054174371.1  E3 ubiquitin-protein ligase NEDD4-like isoform X10

      UniProtKB/TrEMBL
      B7Z2P9

    22. XM_054318410.1 → XP_054174385.1  E3 ubiquitin-protein ligase NEDD4-like isoform X22

      UniProtKB/TrEMBL
      B7Z6K0

    23. XM_054318409.1 → XP_054174384.1  E3 ubiquitin-protein ligase NEDD4-like isoform X22

      UniProtKB/TrEMBL
      B7Z6K0

    24. XM_054318395.1 → XP_054174370.1  E3 ubiquitin-protein ligase NEDD4-like isoform X12

      UniProtKB/TrEMBL
      A0A6Q8PFI7

    25. XM_054318405.1 → XP_054174380.1  E3 ubiquitin-protein ligase NEDD4-like isoform X20

      UniProtKB/TrEMBL
      B7Z2P9

    26. XM_054318407.1 → XP_054174382.1  E3 ubiquitin-protein ligase NEDD4-like isoform X21

      UniProtKB/TrEMBL
      K7ERN1

    27. XM_054318406.1 → XP_054174381.1  E3 ubiquitin-protein ligase NEDD4-like isoform X20

      UniProtKB/TrEMBL
      B7Z2P9

    28. XM_054318408.1 → XP_054174383.1  E3 ubiquitin-protein ligase NEDD4-like isoform X22

      UniProtKB/TrEMBL
      B7Z6K0

    29. XM_054318411.1 → XP_054174386.1  E3 ubiquitin-protein ligase NEDD4-like isoform X9

      UniProtKB/TrEMBL
      B7Z6K0

    30. XM_054318419.1 → XP_054174394.1  E3 ubiquitin-protein ligase NEDD4-like isoform X21

      UniProtKB/TrEMBL
      K7ERN1

    31. XM_054318382.1 → XP_054174357.1  E3 ubiquitin-protein ligase NEDD4-like isoform X1

    32. XM_054318383.1 → XP_054174358.1  E3 ubiquitin-protein ligase NEDD4-like isoform X2

      UniProtKB/TrEMBL
      A0A1B0GVY1

    33. XM_054318384.1 → XP_054174359.1  E3 ubiquitin-protein ligase NEDD4-like isoform X3

    34. XM_054318385.1 → XP_054174360.1  E3 ubiquitin-protein ligase NEDD4-like isoform X4

    35. XM_054318386.1 → XP_054174361.1  E3 ubiquitin-protein ligase NEDD4-like isoform X5

    36. XM_054318387.1 → XP_054174362.1  E3 ubiquitin-protein ligase NEDD4-like isoform X6

    37. XM_054318388.1 → XP_054174363.1  E3 ubiquitin-protein ligase NEDD4-like isoform X7

    38. XM_054318389.1 → XP_054174364.1  E3 ubiquitin-protein ligase NEDD4-like isoform X8

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96PU5.2 GenPept UniProtKB/Swiss-Prot:Q96PU5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools