TONSL-AS1 TONSL antisense RNA 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: TONSL-AS1provided by HGNC
Official Full Name: TONSL antisense RNA 1provided by HGNC
Primary source: HGNC:HGNC:51556
See related: AllianceGenome:HGNC:51556
Gene type: ncRNA
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression: Ubiquitous expression in bone marrow (RPKM 1.2), stomach (RPKM 1.0) and 24 other tissues See more
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Genomic context

Location:: 8q24.3

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	8	NC_000008.11 (144435168..144439893)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	8	NC_060932.1 (145604982..145609706)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	8	NC_000008.10 (145660551..145665276)

Chromosome 8 - NC_000008.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

LncRNA TONSL-AS1 participates in coronary artery disease by interacting with miR-197.
Title: LncRNA TONSL-AS1 participates in coronary artery disease by interacting with miR-197.
LncRNA TONSL-AS1 regulates miR-490-3p/CDK1 to affect ovarian epithelial carcinoma cell proliferation.
Title: LncRNA TONSL-AS1 regulates miR-490-3p/CDK1 to affect ovarian epithelial carcinoma cell proliferation.
TONSL-AS1 was downregulated in gastric cancer tissues and cell lines compared with the normal. TONSL-AS1 inhibited cell migration, invasion and proliferation in SGC-7901, MGC-803cells and suppressed cell tumorigenesis in vivo. TONSL's promoter is activated by TONSL-AS1.TONSL-AS1 was positively associated with TONSL in cancer tissues. TONSL-AS1's tumor-inhibiting effect in gastric cancer cells was associated with TONSL.
Title: A novel long non-coding RNA TONSL-AS1 regulates progression of gastric cancer via activating TONSL.

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Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See studies and variants in dbVar

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General gene information

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NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.