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    Serpina3c serine (or cysteine) peptidase inhibitor, clade A, member 3C [ Mus musculus (house mouse) ]

    Gene ID: 16625, updated on 9-Dec-2024

    Summary

    Official Symbol
    Serpina3cprovided by MGI
    Official Full Name
    serine (or cysteine) peptidase inhibitor, clade A, member 3Cprovided by MGI
    Primary source
    MGI:MGI:102848
    See related
    Ensembl:ENSMUSG00000066361 AllianceGenome:MGI:102848
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1A1; spi2; Kalbp; Klkbp
    Summary
    Predicted to enable serine-type endopeptidase inhibitor activity. Acts upstream of or within response to cytokine and response to peptide hormone. Predicted to be active in extracellular space. Is expressed in thymus primordium. Human ortholog(s) of this gene implicated in chronic obstructive pulmonary disease; cystic fibrosis; and vasculitis. Orthologous to human SERPINA3 (serpin family A member 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in subcutaneous fat pad adult (RPKM 46.6), genital fat pad adult (RPKM 27.6) and 4 other tissues See more
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    Genomic context

    See Serpina3c in Genome Data Viewer
    Location:
    12 E; 12 53.46 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (104113166..104120187, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (104146907..104153929, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene serine (or cysteine) peptidase inhibitor, clade A, member 3A Neighboring gene serine (or cysteine) peptidase inhibitor, clade A, member 3B Neighboring gene serine (or cysteine) peptidase inhibitor, clade A, member 3D, pseudogene Neighboring gene serine (or cysteine) peptidase inhibitor, clade A, member 3E, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC144822

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    serine protease inhibitor A3C
    Names
    KBP
    alpha-1 antiproteinase
    kallikrein-binding protein
    serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3C
    serine (or cysteine) proteinase inhibitor, clade A, member 3C
    serpin A3C

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008458.2NP_032484.1  serine protease inhibitor A3C precursor

      See identical proteins and their annotated locations for NP_032484.1

      Status: PROVISIONAL

      Source sequence(s)
      AC142112
      Consensus CDS
      CCDS26148.1
      UniProtKB/Swiss-Prot
      P29621
      UniProtKB/TrEMBL
      Q14AS7
      Related
      ENSMUSP00000082125.4, ENSMUST00000085050.4
      Conserved Domains (1) summary
      cd02056
      Location:51411
      alpha-1-antitrypsin_like; alpha-1-antitrypsin_like. This family contains a variety of different members of clade A of the serpin superfamily. They include the classical serine proteinase inhibitors, alpha-1-antitrypsin and alpha-1-antichymotrypsin, protein C inhibitor, ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      104113166..104120187 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011244002.4XP_011242304.1  serine protease inhibitor A3C isoform X1

      UniProtKB/TrEMBL
      Q14AS7
      Conserved Domains (1) summary
      cd19551
      Location:56434
      serpinA3_A1AC; serpin family A member 3, alpha 1-antichymotrypsin