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    Hspb1 heat shock protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 15507, updated on 9-Dec-2024

    Summary

    Official Symbol
    Hspb1provided by MGI
    Official Full Name
    heat shock protein 1provided by MGI
    Primary source
    MGI:MGI:96240
    See related
    Ensembl:ENSMUSG00000004951 AllianceGenome:MGI:96240
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    27kDa; Hsp25
    Summary
    Enables protein kinase C binding activity and protein kinase C inhibitor activity. Involved in negative regulation of protein kinase activity; positive regulation of cytokine production; and regulation of intracellular signal transduction. Acts upstream of or within negative regulation of apoptotic signaling pathway. Located in Z disc; nucleus; and plasma membrane. Is active in cornified envelope. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2F; autosomal dominant distal hereditary motor neuronopathy 3; pancreatic cancer; and sarcoma. Orthologous to human HSPB1 (heat shock protein family B (small) member 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in stomach adult (RPKM 786.6), placenta adult (RPKM 259.7) and 13 other tissues See more
    Orthologs
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    Genomic context

    See Hspb1 in Genome Data Viewer
    Location:
    5 G2; 5 75.51 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (135916773..135918417)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (135887919..135889563)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene serine/arginine repetitive matrix 3 Neighboring gene STARR-positive B cell enhancer ABC_E6387 Neighboring gene predicted gene, 22450 Neighboring gene tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide Neighboring gene STARR-seq mESC enhancer starr_14600 Neighboring gene predicted gene, 40346 Neighboring gene STARR-seq mESC enhancer starr_14605 Neighboring gene STARR-positive B cell enhancer ABC_E235 Neighboring gene STARR-positive B cell enhancer ABC_E1311 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:136438585-136438772 Neighboring gene scavenger receptor cysteine rich family, 4 domains

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA polymerase II-specific DNA-binding transcription factor binding  
    enables RNA polymerase II-specific DNA-binding transcription factor binding  
    enables identical protein binding  
    enables identical protein binding  
    enables protein folding chaperone  
    enables protein folding chaperone  
    enables protein homodimerization activity  
    enables protein homodimerization activity  
    enables protein kinase C binding PubMed 
    enables protein kinase C inhibitor activity PubMed 
    enables protein kinase binding  
    enables ubiquitin binding  
    enables ubiquitin binding  
    enables unfolded protein binding  
    Items 1 - 25 of 31
    Process Evidence Code Pubs
    involved_in anterograde axonal protein transport  
    involved_in anterograde axonal protein transport  
    involved_in cellular response to vascular endothelial growth factor stimulus  
    involved_in cellular response to vascular endothelial growth factor stimulus  
    involved_in chaperone-mediated protein folding  
    involved_in chaperone-mediated protein folding  
    involved_in intracellular signal transduction  
    involved_in intracellular signal transduction  
    involved_in negative regulation of apoptotic process  
    acts_upstream_of_or_within negative regulation of apoptotic signaling pathway PubMed 
    involved_in negative regulation of cellular response to oxidative stress  
    involved_in negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway PubMed 
    involved_in negative regulation of protein kinase activity PubMed 
    involved_in negative regulation of regulatory T cell differentiation  
    involved_in positive regulation of angiogenesis  
    involved_in positive regulation of angiogenesis  
    involved_in positive regulation of blood vessel endothelial cell migration  
    involved_in positive regulation of blood vessel endothelial cell migration  
    involved_in positive regulation of endothelial cell chemotaxis  
    involved_in positive regulation of endothelial cell chemotaxis  
    involved_in positive regulation of interleukin-1 beta production PubMed 
    involved_in positive regulation of neuron projection development  
    involved_in positive regulation of tumor necrosis factor production PubMed 
    involved_in protein refolding  
    involved_in regulation of canonical NF-kappaB signal transduction PubMed 
    involved_in regulation of protein phosphorylation  
    involved_in response to heat  
    involved_in response to unfolded protein PubMed 
    involved_in response to virus  
    involved_in vascular endothelial growth factor receptor signaling pathway  
    involved_in vascular endothelial growth factor receptor signaling pathway  
    Items 1 - 25 of 31
    Items 1 - 20 of 22
    Component Evidence Code Pubs
    located_in I band  
    located_in M band  
    located_in Z disc PubMed 
    located_in axon  
    located_in axon cytoplasm  
    located_in cardiac myofibril  
    located_in contractile muscle fiber PubMed 
    is_active_in cornified envelope PubMed 
    is_active_in cytoplasm  
    located_in cytoplasm PubMed 
    located_in cytoplasm  
    located_in dendrite  
    located_in intracellular anatomical structure PubMed 
    is_active_in nucleus  
    located_in nucleus PubMed 
    located_in nucleus  
    located_in perikaryon  
    located_in plasma membrane PubMed 
    located_in postsynaptic density membrane  
    part_of proteasome complex  
    part_of proteasome complex  
    located_in spindle  
    Items 1 - 20 of 22

    General protein information

    Preferred Names
    heat shock protein beta-1
    Names
    HSP 25
    HSP 27
    growth-related 25 kDa protein
    heat shock 25 kDa protein
    heat shock 27 kDa protein
    heat shock 27kDa protein 1
    heat shock protein, 25 kDa
    p25

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013560.2NP_038588.2  heat shock protein beta-1

      See identical proteins and their annotated locations for NP_038588.2

      Status: VALIDATED

      Source sequence(s)
      AA013886, AV458710, BC099463
      Consensus CDS
      CCDS39320.1
      UniProtKB/Swiss-Prot
      P14602
      UniProtKB/TrEMBL
      Q545F4
      Related
      ENSMUSP00000005077.7, ENSMUST00000005077.7
      Conserved Domains (1) summary
      cd06475
      Location:88173
      ACD_HspB1_like; Alpha crystallin domain (ACD) found in mammalian small (s)heat shock protein (Hsp)-27 (also denoted HspB1 in human) and similar proteins. sHsps are molecular chaperones that suppress protein aggregation and protect against cell stress, and are generally ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      135916773..135918417
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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