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    Maf1 MAF1 homolog, negative regulator of RNA polymerase III [ Mus musculus (house mouse) ]

    Gene ID: 68877, updated on 9-Dec-2024

    Summary

    Official Symbol
    Maf1provided by MGI
    Official Full Name
    MAF1 homolog, negative regulator of RNA polymerase IIIprovided by MGI
    Primary source
    MGI:MGI:1916127
    See related
    Ensembl:ENSMUSG00000022553 AllianceGenome:MGI:1916127
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1110068E11Rik
    Summary
    Predicted to enable GABA receptor binding activity; RNA polymerase III cis-regulatory region sequence-specific DNA binding activity; and RNA polymerase III core binding activity. Involved in negative regulation of transcription by RNA polymerase III. Located in nucleus. Is expressed in adrenal gland; liver; retina; and thymus. Orthologous to human MAF1 (MAF1 homolog, negative regulator of RNA polymerase III). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in thymus adult (RPKM 55.3), ovary adult (RPKM 45.4) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Maf1 in Genome Data Viewer
    Location:
    15 D3; 15 35.75 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (76235494..76238578)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (76351294..76354378)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene cytochrome c-1 Neighboring gene SHANK-associated RH domain interacting protein Neighboring gene WD repeat domain 97 Neighboring gene STARR-seq mESC enhancer starr_39052 Neighboring gene STARR-positive B cell enhancer ABC_E11592 Neighboring gene HGH1 homolog

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    located_in inhibitory synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    repressor of RNA polymerase III transcription MAF1 homolog

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164607.1NP_001158079.1  repressor of RNA polymerase III transcription MAF1 homolog

      See identical proteins and their annotated locations for NP_001158079.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript.
      Source sequence(s)
      AK004406, BY118992, BY595681, CK619143
      Consensus CDS
      CCDS27568.1
      UniProtKB/Swiss-Prot
      Q3U4U3, Q91W84, Q9D0U6
      Related
      ENSMUSP00000125387.2, ENSMUST00000161527.8
      Conserved Domains (1) summary
      pfam09174
      Location:25202
      Maf1; Maf1 regulator
    2. NM_001164608.1NP_001158080.1  repressor of RNA polymerase III transcription MAF1 homolog

      See identical proteins and their annotated locations for NP_001158080.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2, and 3, encode the same protein.
      Source sequence(s)
      AK042913, BY118992
      Consensus CDS
      CCDS27568.1
      UniProtKB/Swiss-Prot
      Q3U4U3, Q91W84, Q9D0U6
      Related
      ENSMUSP00000124893.2, ENSMUST00000160853.8
      Conserved Domains (1) summary
      pfam09174
      Location:25202
      Maf1; Maf1 regulator
    3. NM_026859.3NP_081135.3  repressor of RNA polymerase III transcription MAF1 homolog

      See identical proteins and their annotated locations for NP_081135.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2, and 3, encode the same protein.
      Source sequence(s)
      AK004406, AK042913, BB250147, BY118992
      Consensus CDS
      CCDS27568.1
      UniProtKB/Swiss-Prot
      Q3U4U3, Q91W84, Q9D0U6
      Related
      ENSMUSP00000023212.9, ENSMUST00000023212.15
      Conserved Domains (1) summary
      pfam09174
      Location:25202
      Maf1; Maf1 regulator

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      76235494..76238578
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)