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    Slc25a23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23 [ Mus musculus (house mouse) ]

    Gene ID: 66972, updated on 9-Dec-2024

    Summary

    Official Symbol
    Slc25a23provided by MGI
    Official Full Name
    solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23provided by MGI
    Primary source
    MGI:MGI:1914222
    See related
    Ensembl:ENSMUSG00000046329 AllianceGenome:MGI:1914222
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SCaMC-3; 2310067G05Rik
    Summary
    Predicted to enable ADP:phosphate antiporter activity and ATP:phosphate antiporter activity. Acts upstream of or within several processes, including adenine nucleotide transport; cellular response to calcium ion; and regulation of oxidative phosphorylation. Located in mitochondrion. Is expressed in embryo. Orthologous to human SLC25A23 (solute carrier family 25 member 23). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in liver adult (RPKM 76.5), cortex adult (RPKM 70.0) and 27 other tissues See more
    Orthologs
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    Genomic context

    See Slc25a23 in Genome Data Viewer
    Location:
    17 D; 17 29.64 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (57350711..57366863, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (57043711..57059909, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene KH-type splicing regulatory protein Neighboring gene STARR-positive B cell enhancer ABC_E142 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:57171392-57171575 Neighboring gene solute carrier family 25, member 41 Neighboring gene STARR-positive B cell enhancer ABC_E3211 Neighboring gene crumbs family member 3 Neighboring gene DENN domain containing 1C

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (1)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ADP:phosphate antiporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ADP:phosphate antiporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables ATP transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ATP:phosphate antiporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ATP:phosphate antiporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables adenine nucleotide transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables adenine nucleotide transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in ADP transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in ADP transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ATP transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within adenine nucleotide transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in adenine nucleotide transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in adenine nucleotide transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in calcium import into the mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in calcium import into the mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within cellular response to calcium ion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mitochondrial ATP transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitochondrial ATP transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in mitochondrial calcium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitochondrial calcium ion transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of mitochondrial calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of mitochondrial calcium ion concentration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of cellular hyperosmotic salinity response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cellular hyperosmotic salinity response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within regulation of cellular respiration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of oxidative phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of sequestering of calcium ion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within renal system process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    mitochondrial adenyl nucleotide antiporter SLC25A23
    Names
    calcium-binding mitochondrial carrier protein SCaMC-3
    short calcium-binding mitochondrial carrier protein 3
    small calcium-binding mitochondrial carrier protein 3
    solute carrier family 25 member 23

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001379067.1NP_001365996.1  mitochondrial adenyl nucleotide antiporter SLC25A23 isoform 2

      Status: VALIDATED

      Source sequence(s)
      CT571247
      Conserved Domains (2) summary
      COG5126
      Location:7142
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
      PTZ00169
      Location:189475
      PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
    2. NM_001379068.1NP_001365997.1  mitochondrial adenyl nucleotide antiporter SLC25A23 isoform 3

      Status: VALIDATED

      Source sequence(s)
      CT571247
      Conserved Domains (2) summary
      COG5126
      Location:7142
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
      PTZ00169
      Location:189426
      PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
    3. NM_001379069.1NP_001365998.1  mitochondrial adenyl nucleotide antiporter SLC25A23 isoform 4

      Status: VALIDATED

      Source sequence(s)
      CT571247
      Conserved Domains (2) summary
      COG5126
      Location:7142
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
      pfam00153
      Location:223316
      Mito_carr; Mitochondrial carrier protein
    4. NM_001379070.1NP_001365999.1  mitochondrial adenyl nucleotide antiporter SLC25A23 isoform 5

      Status: VALIDATED

      Source sequence(s)
      CT571247
      Conserved Domains (1) summary
      PTZ00169
      Location:66339
      PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
    5. NM_001412719.1NP_001399648.1  mitochondrial adenyl nucleotide antiporter SLC25A23 isoform 6

      Status: VALIDATED

      Source sequence(s)
      CT571247
    6. NM_025877.4NP_080153.2  mitochondrial adenyl nucleotide antiporter SLC25A23 isoform 1

      See identical proteins and their annotated locations for NP_080153.2

      Status: VALIDATED

      Source sequence(s)
      BC017139, BC072660, CX566083
      Consensus CDS
      CCDS28923.1
      UniProtKB/Swiss-Prot
      Q6GQS1
      Related
      ENSMUSP00000040198.8, ENSMUST00000040280.14
      Conserved Domains (4) summary
      cd00051
      Location:84141
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      PTZ00169
      Location:189462
      PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
      pfam00153
      Location:274367
      Mito_carr; Mitochondrial carrier protein
      pfam13499
      Location:81136
      EF-hand_7; EF-hand domain pair

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      57350711..57366863 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)