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    Trp53inp2 transformation related protein 53 inducible nuclear protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 68728, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Trp53inp2provided by MGI
    Official Full Name
    transformation related protein 53 inducible nuclear protein 2provided by MGI
    Primary source
    MGI:MGI:1915978
    See related
    Ensembl:ENSMUSG00000038375 AllianceGenome:MGI:1915978
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tp53inp2; 1110029F20Rik
    Summary
    Enables ubiquitin binding activity. Acts upstream of or within several processes, including macroautophagy; osteoblast differentiation; and ubiquitin-dependent protein catabolic process. Predicted to be located in cytosol. Predicted to be active in autophagosome and nucleus. Is expressed in several structures, including 1st branchial arch; facial prominence; limb mesenchyme; nervous system; and otocyst. Orthologous to human TP53INP2 (tumor protein p53 inducible nuclear protein 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 127.9), heart adult (RPKM 122.6) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Trp53inp2 in Genome Data Viewer
    Location:
    2 H1; 2 77.26 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (155223742..155231767)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (155381811..155389847)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene microtubule-associated protein 1 light chain 3 alpha Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class U Neighboring gene STARR-positive B cell enhancer ABC_E6004 Neighboring gene microRNA 695 Neighboring gene STARR-positive B cell enhancer ABC_E11173 Neighboring gene STARR-positive B cell enhancer ABC_E4511 Neighboring gene nuclear receptor coactivator 6 Neighboring gene ribosomal protein L8 pseudogene Neighboring gene carnitine deficiency-associated gene expressed in ventricle 3 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. TP53INP2 knockdown inhibits inflammatory response and apoptosis after spinal cord injury. Sun P, et al. Immun Inflamm Dis, 2024 Apr. PMID 38652010, Free PMC Article
    2. TP53INP2-dependent activation of muscle autophagy ameliorates sarcopenia and promotes healthy aging. Sebastián D, et al. Autophagy, 2024 Aug. PMID 38545813, Free PMC Article
    3. Metabolic status differentiates Trp53inp2 function in pressure-overload induced heart failure. Liu J, et al. Front Cardiovasc Med, 2023. PMID 38188257, Free PMC Article
    4. Role of diabetes- and obesity-related protein in the regulation of osteoblast differentiation. Linares GR, et al. Am J Physiol Endocrinol Metab, 2011 Jul. PMID 21467300, Free PMC Article
    5. The coding region of TP53INP2, a gene expressed in the developing nervous system, is not altered in a family with autosomal recessive non-progressive infantile ataxia on chromosome 20q11-q13. Bennetts JS, et al. Dev Dyn, 2007 Mar. PMID 17238154

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TP53INP2-dependent activation of muscle autophagy ameliorates sarcopenia and promotes healthy aging.
      Title: TP53INP2-dependent activation of muscle autophagy ameliorates sarcopenia and promotes healthy aging.
    2. TP53INP2 knockdown inhibits inflammatory response and apoptosis after spinal cord injury.
      Title: TP53INP2 knockdown inhibits inflammatory response and apoptosis after spinal cord injury.
    3. Tp53inp2 is an atypical mRNA that regulates axon growth by enhancing NGF-TrkA signaling in a translation-independent manner.
      Title: Regulation of NGF Signaling by an Axonal Untranslated mRNA.
    4. TP53INP2 modulates adipogenesis through autophagy-dependent sequestration of GSK3beta into late endosomes and beta catenin activation, regulating adiposity.
      Title: TP53INP2 regulates adiposity by activating β-catenin through autophagy-dependent sequestration of GSK3β.
    5. TP53INP2 repression is part of an adaptive mechanism aimed at preserving muscle mass under conditions in which insulin action is deficient.
      Title: Autophagy-regulating TP53INP2 mediates muscle wasting and is repressed in diabetes.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ubiquitin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in autophagosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in autophagosome assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within macroautophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of protein localization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within osteoblast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of protein localization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within tissue homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in PML body IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in autophagosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in autophagosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in autophagosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    tumor protein p53-inducible nuclear protein 2
    Names
    diabetes and obesity-regulated protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001418655.1 → NP_001405584.1  tumor protein p53-inducible nuclear protein 2 isoform a

      Status: VALIDATED

      Source sequence(s)
      AL845325
      UniProtKB/Swiss-Prot
      Q3TDL6, Q711P5, Q8CFU8, Q8CHM4

    2. NM_001418656.1 → NP_001405585.1  tumor protein p53-inducible nuclear protein 2 isoform a

      Status: VALIDATED

      Source sequence(s)
      AL845325
      UniProtKB/Swiss-Prot
      Q3TDL6, Q711P5, Q8CFU8, Q8CHM4

    3. NM_001418657.1 → NP_001405586.1  tumor protein p53-inducible nuclear protein 2 isoform a

      Status: VALIDATED

      Source sequence(s)
      AL845325
      UniProtKB/Swiss-Prot
      Q3TDL6, Q711P5, Q8CFU8, Q8CHM4

    4. NM_001418658.1 → NP_001405587.1  tumor protein p53-inducible nuclear protein 2 isoform b

      Status: VALIDATED

      Source sequence(s)
      AL845325
      Related
      ENSMUSP00000133880.2, ENSMUST00000174685.8

    5. NM_001418659.1 → NP_001405588.1  tumor protein p53-inducible nuclear protein 2 isoform b

      Status: VALIDATED

      Source sequence(s)
      AL845325

    6. NM_001418660.1 → NP_001405589.1  tumor protein p53-inducible nuclear protein 2 isoform c

      Status: VALIDATED

      Source sequence(s)
      AL845325

    7. NM_001418661.1 → NP_001405590.1  tumor protein p53-inducible nuclear protein 2 isoform d

      Status: VALIDATED

      Source sequence(s)
      AL845325

    8. NM_178111.4 → NP_835212.1  tumor protein p53-inducible nuclear protein 2 isoform a

      See identical proteins and their annotated locations for NP_835212.1

      Status: VALIDATED

      Source sequence(s)
      AL845325
      Consensus CDS
      CCDS16947.1
      UniProtKB/Swiss-Prot
      Q3TDL6, Q711P5, Q8CFU8, Q8CHM4
      Related
      ENSMUSP00000037627.8, ENSMUST00000043237.14
      Conserved Domains (1) summary
      pfam14839
      Location:28 → 212
      DOR; DOR family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      155223742..155231767
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030252040.2 → XP_030107900.1  tumor protein p53-inducible nuclear protein 2 isoform X3

      Conserved Domains (1) summary
      pfam14839
      Location:72 → 217
      DOR; DOR family

    2. XM_017319242.2 → XP_017174731.1  tumor protein p53-inducible nuclear protein 2 isoform X3

      Conserved Domains (1) summary
      pfam14839
      Location:72 → 217
      DOR; DOR family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CFU8.4 GenPept UniProtKB/Swiss-Prot:Q8CFU8

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