Ncoa6 nuclear receptor coactivator 6 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ncoa6provided by MGI
Official Full Name: nuclear receptor coactivator 6provided by MGI
Primary source: MGI:MGI:1929915
See related: Ensembl:ENSMUSG00000038369 AllianceGenome:MGI:1929915
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: NRC; AIB3; ASC2; PRIP; ASC-2; Ncoa7; RAP250; mKIAA0181
Summary: Enables several functions, including chromatin-protein adaptor activity; histone methyltransferase binding activity; and transcription coactivator activity. Acts upstream of or within brain development; circulatory system development; and positive regulation of DNA-templated transcription. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and sensory organ. Used to study dilated cardiomyopathy. Human ortholog(s) of this gene implicated in breast cancer; colon cancer; and lung cancer. Orthologous to human NCOA6 (nuclear receptor coactivator 6). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in testis adult (RPKM 15.8), whole brain E14.5 (RPKM 15.2) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 H1; 2 77.26 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (155232585..155315741, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (155390656..155473911, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Nuclear receptor coactivator 6 is a critical regulator of NLRP3 inflammasome activation and gouty arthritis.
Title: Nuclear receptor coactivator 6 is a critical regulator of NLRP3 inflammasome activation and gouty arthritis.
Regulation of Hepatic Gluconeogenesis by Nuclear Receptor Coactivator 6.
Title: Regulation of Hepatic Gluconeogenesis by Nuclear Receptor Coactivator 6.
PRIP deficiency impairs osteoclast differentiation, particularly at the early stages, and PRIP stimulates osteoclast differentiation through calcium-calcineurin-NFATc1 signaling via regulating intracellular Ca(2+)
Title: Phospholipase C-related, but catalytically inactive protein (PRIP) up-regulates osteoclast differentiation via calcium-calcineurin-NFATc1 signaling.
The results suggest that NCOA6 stimulates insulin secretion, at least partially, by modulating Nampt expression in pancreatic beta-cells.
Title: Regulation of Nampt expression by transcriptional coactivator NCOA6 in pancreatic β-cells.
These results indicate that PRIP is implicated in BMP-induced osteoblast differentiation by the negative regulation of Smad phosphorylation, through the methylation of inhibitory Smad6.
Title: Involvement of PRIP (Phospholipase C-Related But Catalytically Inactive Protein) in BMP-Induced Smad Signaling in Osteoblast Differentiation.
The results indicate that PRIP negatively regulates UCP1-mediated thermogenesis in brown adipocytes.
Title: Phospholipase C-related Catalytically Inactive Protein Is a New Modulator of Thermogenesis Promoted by β-Adrenergic Receptors in Brown Adipocytes.
Two independent mouse models of NCOA6 dysfunction develop severe dilated cardiomyopathy with impaired mitochondrial function and reduced activity of peroxisome proliferator-activated receptor delta.
Title: Perturbation of NCOA6 leads to dilated cardiomyopathy.
The NCOA6 controls E(2) sensitivity and uterine receptivity by regulating multiple E(2)-signaling components.
Title: Nuclear receptor coactivator-6 attenuates uterine estrogen sensitivity to permit embryo implantation.
ASC-2 negatively affects hepatic insulin sensitivity, at least in part, through induction of the insulin signalling inhibitors SOCS1 and SOCS3.
Title: Regulation of hepatic insulin sensitivity by activating signal co-integrator-2.
PRIP is implicated in the negative regulation of bone formation
Title: Involvement of PRIP, phospholipase C-related, but catalytically inactive protein, in bone formation.

Submit: New GeneRIF Correction See all GeneRIFs (29)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (10) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Ncoa6 (e-PCR), detects polymorphism
- UniSTS:532241

PMC141133P1 (e-PCR)
- UniSTS:270987

Ncoa6 (e-PCR), detects polymorphism
- UniSTS:547272

D20S712E (e-PCR)
- UniSTS:153808

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables chromatin-protein adaptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables histone methyltransferase binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables nuclear estrogen receptor binding	ISO Inferred from Sequence Orthology more info
enables nuclear glucocorticoid receptor binding	ISO Inferred from Sequence Orthology more info
enables nuclear receptor coactivator activity	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear receptor coactivator activity	ISO Inferred from Sequence Orthology more info
enables nuclear retinoic acid receptor binding	ISO Inferred from Sequence Orthology more info
enables nuclear retinoid X receptor binding	ISO Inferred from Sequence Orthology more info
enables nuclear thyroid hormone receptor binding	ISO Inferred from Sequence Orthology more info
enables nuclear thyroid hormone receptor binding	ISS Inferred from Sequence or Structural Similarity more info
enables nuclear vitamin D receptor binding	ISO Inferred from Sequence Orthology more info
enables peroxisome proliferator activated receptor binding	ISO Inferred from Sequence Orthology more info
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info
enables transcription coactivator activity	IDA Inferred from Direct Assay more info	PubMed
enables transcription coactivator activity	ISO Inferred from Sequence Orthology more info
enables transcription coactivator activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA damage response	ISO Inferred from Sequence Orthology more info	PubMed
involved_in DNA-templated transcription initiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within brain development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chromatin organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within heart development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within labyrinthine layer blood vessel development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in myeloid cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in myeloid cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of peptide secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of MLL3/4 complex	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
part_of histone methyltransferase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of histone methyltransferase complex	ISO Inferred from Sequence Orthology more info	PubMed
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info	PubMed
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
part_of transcription regulator complex	IBA Inferred from Biological aspect of Ancestor more info
part_of transcription regulator complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: nuclear receptor coactivator 6

Names: PPAR interacting protein PRIP; PPAR-interacting protein; activating signal cointegrator 2; amplified in breast cancer protein 3; cancer-amplified transcriptional coactivator ASC-2; nuclear receptor coactivator RAP250; nuclear receptor-activating protein 250; nuclear receptor-activating protein, 250 kDa; peroxisome proliferator-activated receptor interacting protein,PRIP; peroxisome proliferator-activated receptor-interacting protein; thyroid hormone receptor binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001242558.2 → NP_001229487.1 nuclear receptor coactivator 6 isoform 2

See identical proteins and their annotated locations for NP_001229487.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an in-frame coding exon compared to variant 1. This results in a shorter isoform (2, also known as Ncoa6-beta) missing an internal protein segment compared to isoform 1.

Source sequence(s)

AL844852, AL845325

UniProtKB/TrEMBL

F6M2J9, F6M2K1

Conserved Domains (3) summary

PHA03247
Location:145 → 550

PHA03247; large tegument protein UL36; Provisional

pfam09606
Location:471 → 864

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

pfam13820
Location:48 → 189

Nucleic_acid_bd; Putative nucleic acid-binding region
NM_001406325.1 → NP_001393254.1 nuclear receptor coactivator 6 isoform 1

Status: VALIDATED

Source sequence(s)

AL844852, AL845325

UniProtKB/TrEMBL

Q5XJV5

Related

ENSMUSP00000045386.6, ENSMUST00000043126.12
NM_001406326.1 → NP_001393255.1 nuclear receptor coactivator 6 isoform 1

Status: VALIDATED

Source sequence(s)

AL844852, AL845325

UniProtKB/TrEMBL

Q5XJV5
NM_019825.4 → NP_062799.2 nuclear receptor coactivator 6 isoform 1

See identical proteins and their annotated locations for NP_062799.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1, also known as Ncoa6-alpha)

Source sequence(s)

AL844852, AL845325

Consensus CDS

CCDS38295.1

UniProtKB/Swiss-Prot

Q9JL19, Q9JLT9

UniProtKB/TrEMBL

Q5XJV5

Related

ENSMUSP00000105295.2, ENSMUST00000109670.8

Conserved Domains (4) summary

PHA03247
Location:1173 → 1810

PHA03247; large tegument protein UL36; Provisional

pfam09606
Location:471 → 864

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

pfam08580
Location:1082 → 1326

KAR9; Yeast cortical protein KAR9

pfam13820
Location:48 → 189

Nucleic_acid_bd; Putative nucleic acid-binding region