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    Aqp7 aquaporin 7 [ Mus musculus (house mouse) ]

    Gene ID: 11832, updated on 9-Dec-2024

    Summary

    Official Symbol
    Aqp7provided by MGI
    Official Full Name
    aquaporin 7provided by MGI
    Primary source
    MGI:MGI:1314647
    See related
    Ensembl:ENSMUSG00000028427 AllianceGenome:MGI:1314647
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AQP7L; AQPap
    Summary
    Predicted to enable glycerol channel activity; urea channel activity; and water channel activity. Acts upstream of or within glycerol transmembrane transport and renal water absorption. Located in plasma membrane. Colocalizes with lipid droplet. Is expressed in early conceptus; genitourinary system; inner ear; and liver. Orthologous to several human genes including AQP7 (aquaporin 7). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis adult (RPKM 55.7), subcutaneous fat pad adult (RPKM 41.1) and 7 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Aqp7 in Genome Data Viewer
    Location:
    4 A5; 4 20.83 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (41033074..41048237, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (41033074..41048237, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene charged multivesicular body protein 5 Neighboring gene STARR-positive B cell enhancer ABC_E3485 Neighboring gene predicted gene, 52692 Neighboring gene nuclear transcription factor, X-box binding 1 Neighboring gene microRNA 3094 Neighboring gene predicted gene, 25637 Neighboring gene aquaporin 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Gene trapped (1) 
    • Targeted (6)  1 citation

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables glycerol channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables glycerol channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables glycerol channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables urea channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables urea transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables urea transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables water channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables water channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables water channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables water channel activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in glycerol transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within glycerol transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in glycerol transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in glycerol transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within renal water absorption IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in urea transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in urea transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in water transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in water transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in water transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within water transport TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in basolateral plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in brush border membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell-cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasmic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with lipid droplet IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    part_of ribonucleoprotein complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    aquaporin-7
    Names
    AQP-7
    aquaglyceroporin-7

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001378638.1NP_001365567.1  aquaporin-7 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL837521
      Conserved Domains (1) summary
      cl00200
      Location:18232
      MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...
    2. NM_001378639.1NP_001365568.1  aquaporin-7 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL837521
      UniProtKB/Swiss-Prot
      O54794, Q8C630
      UniProtKB/TrEMBL
      Q5DX24
      Related
      ENSMUSP00000093007.4, ENSMUST00000054945.8
      Conserved Domains (1) summary
      cl00200
      Location:18265
      MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...
    3. NM_001378640.1NP_001365569.1  aquaporin-7 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL837521
      Conserved Domains (1) summary
      cl00200
      Location:44202
      MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...
    4. NM_001378641.1NP_001365570.1  aquaporin-7 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL837521
      Conserved Domains (1) summary
      cl00200
      Location:44235
      MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...
    5. NM_001378642.1NP_001365571.1  aquaporin-7 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL837521
      Conserved Domains (1) summary
      cl00200
      Location:44235
      MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...
    6. NM_007473.5NP_031499.1  aquaporin-7 isoform 2

      See identical proteins and their annotated locations for NP_031499.1

      Status: VALIDATED

      Source sequence(s)
      AL837521
      Consensus CDS
      CCDS18055.1
      UniProtKB/Swiss-Prot
      O54794, Q8C630
      UniProtKB/TrEMBL
      Q5DX24
      Related
      ENSMUSP00000030136.7, ENSMUST00000030136.13
      Conserved Domains (1) summary
      cl00200
      Location:18265
      MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      41033074..41048237 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006537560.5XP_006537623.2  aquaporin-7 isoform X2

      See identical proteins and their annotated locations for XP_006537623.2

      UniProtKB/Swiss-Prot
      O54794, Q8C630
      UniProtKB/TrEMBL
      Q5DX24
      Conserved Domains (1) summary
      cl00200
      Location:18265
      MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...
    2. XM_006537559.5XP_006537622.2  aquaporin-7 isoform X1

      See identical proteins and their annotated locations for XP_006537622.2

      Conserved Domains (1) summary
      cl00200
      Location:18232
      MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...
    3. XM_006537563.2XP_006537626.1  aquaporin-7 isoform X1

      See identical proteins and their annotated locations for XP_006537626.1

      Conserved Domains (1) summary
      cl00200
      Location:18232
      MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...
    4. XM_030253099.2XP_030108959.1  aquaporin-7 isoform X1

      Conserved Domains (1) summary
      cl00200
      Location:18232
      MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...
    5. XM_036163606.1XP_036019499.1  aquaporin-7 isoform X3

      Conserved Domains (1) summary
      cl00200
      Location:20179
      MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...
    6. XM_017319925.2XP_017175414.1  aquaporin-7 isoform X4