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    Fgfrl1 fibroblast growth factor receptor-like 1 [ Mus musculus (house mouse) ]

    Gene ID: 116701, updated on 9-Dec-2024

    Summary

    Official Symbol
    Fgfrl1provided by MGI
    Official Full Name
    fibroblast growth factor receptor-like 1provided by MGI
    Primary source
    MGI:MGI:2150920
    See related
    Ensembl:ENSMUSG00000008090 AllianceGenome:MGI:2150920
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    FGFR5; FGFR5beta; FGFR5gamma
    Summary
    Enables fibroblast growth factor binding activity and fibroblast growth factor receptor activity. Acts upstream of or within several processes, including diaphragm development; heart development; and skeletal system development. Located in plasma membrane. Is expressed in several structures, including alimentary system; brain; musculoskeletal system; respiratory system; and sensory organ. Used to study Wolf-Hirschhorn syndrome. Orthologous to human FGFRL1 (fibroblast growth factor receptor like 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in subcutaneous fat pad adult (RPKM 80.9), genital fat pad adult (RPKM 60.2) and 26 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Fgfrl1 in Genome Data Viewer
    Location:
    5 F; 5 53.24 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (108842051..108854816)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (108694229..108706950)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene iduronidase, alpha-L Neighboring gene solute carrier family 26 (sulfate transporter), member 1 Neighboring gene predicted gene, 42151 Neighboring gene ring finger protein 212 Neighboring gene RIKEN cDNA 1700047L14 gene Neighboring gene 40S ribosomal protein S8 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (5)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables fibroblast growth factor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables fibroblast growth factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables fibroblast growth factor receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables fibroblast growth factor receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables fibroblast growth factor receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables heparin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables heparin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables non-tyrosine kinase fibroblast growth factor receptor activity ISA
    Inferred from Sequence Alignment
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell-cell contact zone IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell-cell contact zone ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane ISA
    Inferred from Sequence Alignment
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in transport vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in transport vesicle ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    fibroblast growth factor receptor-like 1
    Names
    FGF receptor-like protein 1
    fibroblast growth factor receptor 5
    NP_001157731.1
    NP_001412742.1
    NP_001412743.1
    NP_001412744.1
    NP_473412.1
    XP_036020635.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164259.2NP_001157731.1  fibroblast growth factor receptor-like 1 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001157731.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
      Source sequence(s)
      AC123743
      Consensus CDS
      CCDS51592.1
      UniProtKB/Swiss-Prot
      Q91V87
      Related
      ENSMUSP00000108179.4, ENSMUST00000112560.8
      Conserved Domains (3) summary
      cd00096
      Location:151154
      Ig; Ig strand A [structural motif]
      cd05856
      Location:52143
      IgI_2_FGFRL1-like; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor_like-1(FGFRL1); member of the I-set of IgSF domains
      cl11960
      Location:151259
      Ig; Immunoglobulin domain
    2. NM_001425813.1NP_001412742.1  fibroblast growth factor receptor-like 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC123743
    3. NM_001425814.1NP_001412743.1  fibroblast growth factor receptor-like 1 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AC123743
      UniProtKB/Swiss-Prot
      Q91V87, Q920C2, Q920C3
    4. NM_001425815.1NP_001412744.1  fibroblast growth factor receptor-like 1 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AC123743
      UniProtKB/Swiss-Prot
      Q91V87, Q920C2, Q920C3
    5. NM_054071.3NP_473412.1  fibroblast growth factor receptor-like 1 isoform 1 precursor

      See identical proteins and their annotated locations for NP_473412.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC123743
      Consensus CDS
      CCDS19518.1
      UniProtKB/Swiss-Prot
      Q91V87, Q920C2, Q920C3
      Related
      ENSMUSP00000013633.9, ENSMUST00000013633.12
      Conserved Domains (3) summary
      cd05856
      Location:153234
      Ig2_FGFRL1-like; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor_like-1(FGFRL1)
      pfam07679
      Location:29112
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:257351
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      108842051..108854816
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036164742.1XP_036020635.1  fibroblast growth factor receptor-like 1 isoform X2

      Conserved Domains (3) summary
      cd00096
      Location:151154
      Ig; Ig strand A [structural motif]
      cd05856
      Location:52143
      IgI_2_FGFRL1-like; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor_like-1(FGFRL1); member of the I-set of IgSF domains
      cl11960
      Location:151259
      Ig; Immunoglobulin domain