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    Gys2 glycogen synthase 2 [ Mus musculus (house mouse) ]

    Gene ID: 232493, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Gys2provided by MGI
    Official Full Name
    glycogen synthase 2provided by MGI
    Primary source
    MGI:MGI:2385254
    See related
    Ensembl:ENSMUSG00000030244 AllianceGenome:MGI:2385254
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    LGS
    Summary
    Enables alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity. Involved in glycogen biosynthetic process. Is active in cytosol. Is expressed in cerebral cortex; heart; and liver. Human ortholog(s) of this gene implicated in glycogen storage disease. Orthologous to human GYS2 (glycogen synthase 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in liver E18 (RPKM 32.0), liver adult (RPKM 14.5) and 7 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Gys2 in Genome Data Viewer
    Location:
    6 G2; 6 74.04 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (142368339..142418856, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (142422612..142473130, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1716 Neighboring gene golgi transport 1B Neighboring gene spexin hormone Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:142438685-142438868 Neighboring gene STARR-seq mESC enhancer starr_17706 Neighboring gene lactate dehydrogenase B Neighboring gene STARR-seq mESC enhancer starr_17707 Neighboring gene predicted gene, 38919

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Impaired glucose tolerance and predisposition to the fasted state in liver glycogen synthase knock-out mice. Irimia JM, et al. J Biol Chem, 2010 Apr 23. PMID 20178984, Free PMC Article
    2. Lack of liver glycogen causes hepatic insulin resistance and steatosis in mice. Irimia JM, et al. J Biol Chem, 2017 Jun 23. PMID 28483921, Free PMC Article
    3. Hepatic overexpression of a constitutively active form of liver glycogen synthase improves glucose homeostasis. Ros S, et al. J Biol Chem, 2010 Nov 26. PMID 20841354, Free PMC Article
    4. PER2 promotes glucose storage to liver glycogen during feeding and acute fasting by inducing Gys2 PTG and G L expression. Zani F, et al. Mol Metab, 2013. PMID 24049741, Free PMC Article
    5. Glucose-6-phosphate-mediated activation of liver glycogen synthase plays a key role in hepatic glycogen synthesis. von Wilamowitz-Moellendorff A, et al. Diabetes, 2013 Dec. PMID 23990365, Free PMC Article

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Identification of BMAL1-Regulated circadian genes in mouse liver and their potential association with hepatocellular carcinoma: Gys2 and Upp2 as promising candidates.
      Title: Identification of BMAL1-Regulated circadian genes in mouse liver and their potential association with hepatocellular carcinoma: Gys2 and Upp2 as promising candidates.
    2. N6-methyladenosine modification governs liver glycogenesis by stabilizing the glycogen synthase 2 mRNA.
      Title: N6-methyladenosine modification governs liver glycogenesis by stabilizing the glycogen synthase 2 mRNA.
    3. These data show that G6P-mediated activation of GYS2 plays a key role in controlling glycogen synthesis and hepatic glucose-G6P flux control and thus whole-body glucose homeostasis.
      Title: Glucose-6-phosphate-mediated activation of liver glycogen synthase plays a key role in hepatic glycogen synthesis.
    4. A stratified transcriptomics analysis of polygenic fat and lean mouse adipose tissues identifies Gys2 as novel candidate obesity genes.
      Title: A stratified transcriptomics analysis of polygenic fat and lean mouse adipose tissues identifies novel candidate obesity genes.
    5. Transgenic LGS mice showed enhanced glycogen storage and an mproved glucose tolerance.
      Title: Hepatic overexpression of a constitutively active form of liver glycogen synthase improves glucose homeostasis.
    6. CLOCK regulates the circadian rhythms of hepatic glycogen synthesis through transcriptional activation of Gys2.
      Title: CLOCK regulates circadian rhythms of hepatic glycogen synthesis through transcriptional activation of Gys2.
    7. Mouse enzyme is a novel target of peroxisome proliferator-activated receptor, which is in turn mediated by two response elements.
      Title: Glycogen synthase 2 is a novel target gene of peroxisome proliferator-activated receptors.
    8. The endogenous glycogen synthase in extracts from mouse liver bound specifically to SAPK2b/p38b & was phosphorylated at residues Ser644, Ser652, Thr718 and Ser724.
      Title: Identification of glycogen synthase as a new substrate for stress-activated protein kinase 2b/p38beta.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (3) 
    • Targeted (3)  1 citation

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC29379

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables D-glucose binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in glycogen biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycogen biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glycogen biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in glycogen biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glycogen biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in glycogen metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to glucose ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to glucose ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cell cortex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell cortex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cortical actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cortical actin cytoskeleton ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoskeleton ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    glycogen [starch] synthase, liver
    Names
    glycogen synthase, liver
    NP_001398553.1
    NP_663547.2
    XP_011239885.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001411624.1 → NP_001398553.1  glycogen [starch] synthase, liver isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC142413

    2. NM_145572.3 → NP_663547.2  glycogen [starch] synthase, liver isoform 1

      See identical proteins and their annotated locations for NP_663547.2

      Status: VALIDATED

      Source sequence(s)
      AC142413
      Consensus CDS
      CCDS20683.1
      UniProtKB/Swiss-Prot
      Q3UTY0, Q8VCB3
      Related
      ENSMUSP00000032371.8, ENSMUST00000032371.8
      Conserved Domains (2) summary
      cd03793
      Location:27 → 615
      GT1_Glycogen_synthase_GSY2_like; Glycogen synthase, which is most closely related to the GT1 family of glycosyltransferases, catalyzes the transfer of a glucose molecule from UDP-glucose to a terminal branch of a glycogen molecule, a rate-limit step of glycogen biosynthesis. GSY2, the ...
      pfam05693
      Location:32 → 657
      Glycogen_syn; Glycogen synthase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      142368339..142418856 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011241583.2 → XP_011239885.1  glycogen [starch] synthase, liver isoform X2

      Conserved Domains (1) summary
      pfam05693
      Location:32 → 355
      Glycogen_syn; Glycogen synthase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VCB3.2 GenPept UniProtKB/Swiss-Prot:Q8VCB3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
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