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    Plin1 perilipin 1 [ Mus musculus (house mouse) ]

    Gene ID: 103968, updated on 9-Dec-2024

    Summary

    Official Symbol
    Plin1provided by MGI
    Official Full Name
    perilipin 1provided by MGI
    Primary source
    MGI:MGI:1890505
    See related
    Ensembl:ENSMUSG00000030546 AllianceGenome:MGI:1890505
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Peri; Plin; 6030432J05Rik
    Summary
    Acts upstream of or within cellular response to cold and lipid catabolic process. Located in cytosol and lipid droplet. Is expressed in blood vessel and connective tissue. Human ortholog(s) of this gene implicated in familial partial lipodystrophy type 4 and obesity. Orthologous to human PLIN1 (perilipin 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in subcutaneous fat pad adult (RPKM 403.0), mammary gland adult (RPKM 366.1) and 4 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Plin1 in Genome Data Viewer
    Location:
    7 D2; 7 45.11 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (79370912..79382652, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (79721164..79732904, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E551 Neighboring gene TOPBP1-interacting checkpoint and replication regulator Neighboring gene uncharacterized LOC118567517 Neighboring gene kinesin family member 7 Neighboring gene STARR-positive B cell enhancer mm9_chr7:86873152-86873453 Neighboring gene peroxisomal biogenesis factor 11 alpha Neighboring gene WD repeat domain 93

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to cold IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within lipid catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    located_in lipid droplet IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in lipid droplet ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lipid droplet TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    perilipin-1
    Names
    lipid droplet-associated protein
    perilipin A
    perilipin B

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001113471.1NP_001106942.1  perilipin-1

      See identical proteins and their annotated locations for NP_001106942.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      BC037748, BC096685, CJ060785
      Consensus CDS
      CCDS21385.1
      UniProtKB/Swiss-Prot
      Q4V9U2, Q8C0F5, Q8CGN5
      Related
      ENSMUSP00000146028.2, ENSMUST00000205915.2
      Conserved Domains (1) summary
      pfam03036
      Location:14391
      Perilipin; Perilipin family
    2. NM_175640.2NP_783571.2  perilipin-1

      See identical proteins and their annotated locations for NP_783571.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      BC037748, BC096685, BY723040
      Consensus CDS
      CCDS21385.1
      UniProtKB/Swiss-Prot
      Q4V9U2, Q8C0F5, Q8CGN5
      Related
      ENSMUSP00000032762.8, ENSMUST00000032762.14
      Conserved Domains (1) summary
      pfam03036
      Location:14391
      Perilipin; Perilipin family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      79370912..79382652 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011250776.3XP_011249078.1  perilipin-1 isoform X1

      See identical proteins and their annotated locations for XP_011249078.1

      UniProtKB/Swiss-Prot
      Q4V9U2, Q8C0F5, Q8CGN5
      Conserved Domains (1) summary
      pfam03036
      Location:14391
      Perilipin; Perilipin family