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    Lrrc59 leucine rich repeat containing 59 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 287633, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Lrrc59provided by RGD
    Official Full Name
    leucine rich repeat containing 59provided by RGD
    Primary source
    RGD:1305092
    See related
    EnsemblRapid:ENSRNOG00000003524 AllianceGenome:RGD:1305092
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable protein serine/threonine phosphatase activity. Predicted to be involved in intracellular signal transduction. Predicted to be located in endoplasmic reticulum and mitochondrial nucleoid. Predicted to be active in cytoplasm. Orthologous to human LRRC59 (leucine rich repeat containing 59). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 397.7), Thymus (RPKM 363.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Lrrc59 in Genome Data Viewer
    Location:
    10q26
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (80069162..80083820)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (79572295..79586953)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (82352390..82367047)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene acyl-CoA synthetase family member 2 Neighboring gene chondroadherin Neighboring gene uncharacterized LOC102555790 Neighboring gene essential meiotic structure-specific endonuclease 1 Neighboring gene mitochondrial ribosomal protein L27 Neighboring gene xylosyltransferase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Ribosome-binding protein p34 is a member of the leucine-rich-repeat-protein superfamily. Ohsumi T, et al. Biochem J, 1993 Sep 1. PMID 7690545, Free PMC Article
    2. The layered structure of human mitochondrial DNA nucleoids. Bogenhagen DF, et al. J Biol Chem, 2008 Feb 8. PMID 18063578
    3. Identification of novel proteins associated with both alpha-synuclein and DJ-1. Jin J, et al. Mol Cell Proteomics, 2007 May. PMID 16854843
    4. RNF207 exacerbates pathological cardiac hypertrophy via post-translational modification of TAB1. Yuan L, et al. Cardiovasc Res, 2023 Mar 17. PMID 35352799
    5. E-cadherin interactome complexity and robustness resolved by quantitative proteomics. Guo Z, et al. Sci Signal, 2014 Dec 2. PMID 25468996, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC105677

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial nucleoid ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear envelope IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    leucine-rich repeat-containing protein 59
    Names
    protein p34

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008280.1 → NP_001008281.1  leucine-rich repeat-containing protein 59

      See identical proteins and their annotated locations for NP_001008281.1

      Status: PROVISIONAL

      Source sequence(s)
      BC086530
      UniProtKB/Swiss-Prot
      Q5RJR8, Q63742
      UniProtKB/TrEMBL
      A0A8I6AVN3, A6HI59
      Related
      ENSRNOP00000092425.2, ENSRNOT00000105494.2
      Conserved Domains (3) summary
      COG4886
      Location:18 → 120
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00031
      Location:19 → 40
      LRR_1; leucine-rich repeat [structural motif]
      cl30717
      Location:135 → 243
      InfB; Translation initiation factor IF-2, a GTPase [Translation, ribosomal structure and biogenesis]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      80069162..80083820
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5RJR8.1 GenPept UniProtKB/Swiss-Prot:Q5RJR8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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