Tom1l1 target of myb1 like 1 membrane trafficking protein [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tom1l1provided by RGD
Official Full Name: target of myb1 like 1 membrane trafficking proteinprovided by RGD
Primary source: RGD:1562626
See related: EnsemblRapid:ENSRNOG00000002474 AllianceGenome:RGD:1562626
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Srcasm; RGD1562626
Summary: Predicted to enable clathrin binding activity; protein kinase activator activity; and protein kinase binding activity. Predicted to be involved in negative regulation of mitotic nuclear division; positive regulation of protein phosphorylation; and signal transduction. Predicted to be located in cytosol. Predicted to be active in endosome and membrane. Orthologous to human TOM1L1 (target of myb1 like 1 membrane trafficking protein). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 137.2), Liver (RPKM 107.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q26

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (75961653..76005725, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (75464577..75508304, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (78173847..78219805, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TOM1L1 is a novel protein involved in the FcepsilonRI signal transduction for the generation of cytokines that acts as a Lyn substrate
Title: TOM1L1 is a Lyn substrate involved in FcepsilonRI signaling in mast cells.

Submit: New GeneRIF Correction

General gene information

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Markers

AI408345 (e-PCR)
- UniSTS:250137

RH132697 (e-PCR)
- UniSTS:215980

RH133245 (e-PCR)
- UniSTS:216528

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables SH3 domain binding	IEA Inferred from Electronic Annotation more info
enables clathrin binding	IBA Inferred from Biological aspect of Ancestor more info
enables clathrin binding	IEA Inferred from Electronic Annotation more info
enables clathrin binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activator activity	IEA Inferred from Electronic Annotation more info
enables protein kinase activator activity	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in activation of protein kinase activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of mitotic nuclear division	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of mitotic nuclear division	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein autophosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info
NOT involved_in regulation of DNA biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi stack	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in endosome	ISO Inferred from Sequence Orthology more info
located_in endosome membrane	IEA Inferred from Electronic Annotation more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: TOM1-like protein 1

Names: Src-activating and signaling molecule protein; Target of Myb-like protein 1; target of myb1-like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001253859.1 → NP_001240788.1 TOM1-like protein 1

Status: VALIDATED

Source sequence(s)

BC169112, CK596986, CO568886

UniProtKB/Swiss-Prot

F1LM81

UniProtKB/TrEMBL

B5DFM1

Related

ENSRNOP00000003369.8, ENSRNOT00000003369.8

Conserved Domains (2) summary

cd03565
Location:14 → 154

VHS_Tom1; VHS domain family, Tom1 subfamily; The VHS domain is an essential part of Tom1 (Target of myb1 - retroviral oncogene) protein. The VHS domain has a superhelical structure similar to the structure of the ARM repeats and is present at the very N-termini of ...

cd14237
Location:198 → 289

GAT_TM1L1; GAT domain found in target of Myb-like protein 1 (Tom1L1)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

75961653..76005725 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063268709.1 → XP_063124779.1 TOM1-like protein 1 isoform X1

UniProtKB/TrEMBL

A0A0H2UHB0, B5DFM1
XM_039085577.2 → XP_038941505.1 TOM1-like protein 1 isoform X2

UniProtKB/TrEMBL

B5DFM1

Conserved Domains (2) summary

cd14237
Location:121 → 212

GAT_TM1L1; canonical GAT domain found in target of Myb-like protein 1 (Tom1L1)

cl02544
Location:1 → 73

VHS_ENTH_ANTH; VHS, ENTH and ANTH domain superfamily
XM_039085579.2 → XP_038941507.1 TOM1-like protein 1 isoform X3

Conserved Domains (1) summary

cl03906
Location:1 → 42

GAT_SF; GAT domain found in eukaryotic GGAs, metazoan Tom1-like proteins, metazoan STAMs, fungal Vps27, and similar proteins
XM_039085578.2 → XP_038941506.1 TOM1-like protein 1 isoform X3

Conserved Domains (1) summary

cl03906
Location:1 → 42

GAT_SF; GAT domain found in eukaryotic GGAs, metazoan Tom1-like proteins, metazoan STAMs, fungal Vps27, and similar proteins