Epn3 epsin 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Epn3provided by RGD
Full Name: epsin 3provided by RGD
Primary source: RGD:1306416
See related: EnsemblRapid:ENSRNOG00000003284 AllianceGenome:RGD:1306416
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable EH domain binding activity; clathrin binding activity; and phospholipid binding activity. Predicted to be involved in endocytosis. Predicted to be located in several cellular components, including clathrin-coated pit; cytoplasmic side of plasma membrane; and perinuclear region of cytoplasm. Predicted to be part of clathrin vesicle coat. Predicted to be active in endosome and plasma membrane. Orthologous to human EPN3 (epsin 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 48.6), Lung (RPKM 27.2) and 4 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q26

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (79935857..79946121, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (79438978..79449516, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (82220762..82231200, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables EH domain binding	IEA Inferred from Electronic Annotation more info
enables EH domain binding	ISO Inferred from Sequence Orthology more info
enables clathrin binding	IBA Inferred from Biological aspect of Ancestor more info
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables phospholipid binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in endocytosis	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cell cortex	IEA Inferred from Electronic Annotation more info
part_of clathrin vesicle coat	IBA Inferred from Biological aspect of Ancestor more info
located_in clathrin-coated pit	IEA Inferred from Electronic Annotation more info
located_in clathrin-coated pit	ISO Inferred from Sequence Orthology more info
located_in clathrin-coated vesicle	IEA Inferred from Electronic Annotation more info
located_in clathrin-coated vesicle	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic side of plasma membrane	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic side of plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: epsin-3

Names: EPS-15-interacting protein 3; epsin-3-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001024791.1 → NP_001019962.1 epsin-3

See identical proteins and their annotated locations for NP_001019962.1

Status: PROVISIONAL

Source sequence(s)

BC097500

UniProtKB/Swiss-Prot

Q4V882

Related

ENSRNOP00000004400.4, ENSRNOT00000004400.7

Conserved Domains (2) summary

smart00726
Location:202 → 221

UIM; Ubiquitin-interacting motif

cd03571
Location:19 → 141

ENTH_epsin; ENTH domain, Epsin family; The epsin (Eps15 interactor) N-terminal homology (ENTH) domain is an evolutionarily conserved protein module found primarily in proteins that participate in clathrin-mediated endocytosis. A set of proteins previously designated ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

79935857..79946121 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006247201.5 → XP_006247263.1 epsin-3 isoform X1

See identical proteins and their annotated locations for XP_006247263.1

UniProtKB/TrEMBL

A0A8I6A3U9, A6HI52

Conserved Domains (2) summary

smart00726
Location:202 → 221

UIM; Ubiquitin-interacting motif

cd03571
Location:19 → 141

ENTH_epsin; ENTH domain, Epsin family; The epsin (Eps15 interactor) N-terminal homology (ENTH) domain is an evolutionarily conserved protein module found primarily in proteins that participate in clathrin-mediated endocytosis. A set of proteins previously designated ...
XM_006247203.5 → XP_006247265.1 epsin-3 isoform X2

See identical proteins and their annotated locations for XP_006247265.1

UniProtKB/Swiss-Prot

Q4V882

Conserved Domains (2) summary

smart00726
Location:202 → 221

UIM; Ubiquitin-interacting motif

cd03571
Location:19 → 141

ENTH_epsin; ENTH domain, Epsin family; The epsin (Eps15 interactor) N-terminal homology (ENTH) domain is an evolutionarily conserved protein module found primarily in proteins that participate in clathrin-mediated endocytosis. A set of proteins previously designated ...
XM_006247202.5 → XP_006247264.1 epsin-3 isoform X1

See identical proteins and their annotated locations for XP_006247264.1

UniProtKB/TrEMBL

A0A8I6A3U9, A6HI52

Related

ENSRNOP00000087165.2, ENSRNOT00000117347.2

Conserved Domains (2) summary

smart00726
Location:202 → 221

UIM; Ubiquitin-interacting motif

cd03571
Location:19 → 141

ENTH_epsin; ENTH domain, Epsin family; The epsin (Eps15 interactor) N-terminal homology (ENTH) domain is an evolutionarily conserved protein module found primarily in proteins that participate in clathrin-mediated endocytosis. A set of proteins previously designated ...