Ndfip1 Nedd4 family interacting protein 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ndfip1provided by RGD
Official Full Name: Nedd4 family interacting protein 1provided by RGD
Primary source: RGD:1310053
See related: EnsemblRapid:ENSRNOG00000013562 AllianceGenome:RGD:1310053
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable WW domain binding activity. Predicted to be involved in several processes, including negative regulation of transport; positive regulation of canonical NF-kappaB signal transduction; and positive regulation of protein ubiquitination. Predicted to act upstream of or within several processes, including negative regulation of interleukin-4 production; negative regulation of type 2 immune response; and regulation of lymphocyte activation. Predicted to be located in cell cortex. Predicted to be active in Golgi apparatus; endoplasmic reticulum; and perinuclear region of cytoplasm. Orthologous to human NDFIP1 (Nedd4 family interacting protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 1005.9), Kidney (RPKM 713.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 18p11

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	18	NC_086036.1 (30516931..30567199)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	18	NC_051353.1 (30265808..30316068)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	18	NC_005117.4 (31574759..31625286)

Chromosome 18 - NC_086036.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables WW domain binding	IEA Inferred from Electronic Annotation more info
enables WW domain binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in CD4-positive, alpha-beta T cell proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of CD4-positive, alpha-beta T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in intracellular iron ion homeostasis	IEA Inferred from Electronic Annotation more info
involved_in intracellular iron ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in metal ion transport	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of CD4-positive, alpha-beta T cell proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of CD4-positive, alpha-beta T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of inflammatory response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interleukin-4 production	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of interleukin-4 production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of isotype switching to IgE isotypes	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of isotype switching to IgE isotypes	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein transport	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of protein transport	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transporter activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of type 2 immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of type 2 immune response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info	PubMed
involved_in positive regulation of protein catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein ubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein ubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of isotype switching to IgG isotypes	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of isotype switching to IgG isotypes	ISO Inferred from Sequence Orthology more info
involved_in regulation of lymphocyte differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of lymphocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in regulation of myeloid leukocyte differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of myeloid leukocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in vacuolar transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in cell cortex	IEA Inferred from Electronic Annotation more info
located_in cell cortex	ISO Inferred from Sequence Orthology more info
located_in dendrite	IEA Inferred from Electronic Annotation more info
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endosome membrane	IEA Inferred from Electronic Annotation more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in perinuclear region of cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: NEDD4 family-interacting protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.