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    Hydin Hydin, axonemal central pair apparatus protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 292017, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Hydinprovided by RGD
    Official Full Name
    Hydin, axonemal central pair apparatus proteinprovided by RGD
    Primary source
    RGD:1562254
    See related
    EnsemblRapid:ENSRNOG00000017178 AllianceGenome:RGD:1562254
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in axonemal central apparatus assembly and cilium movement. Predicted to act upstream of or within epithelial cell development; trachea development; and ventricular system development. Predicted to be located in axonemal central pair projection. Predicted to be active in axoneme. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 5. Orthologous to human HYDIN (HYDIN axonemal central pair apparatus protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 65.9), Lung (RPKM 48.8) and 2 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Hydin in Genome Data Viewer
    Location:
    19q12
    Exon count:
    90
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (55146382..55492660)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (38236996..38583271)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (41036507..41379634, complement)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134483364 Neighboring gene cap methyltransferase 2 Neighboring gene uncharacterized LOC134483367 Neighboring gene transfer RNA glycine (anticodon GCC) 10 Neighboring gene transfer RNA glycine (anticodon GCC) 9 Neighboring gene VAC14 component of PIKFYVE complex

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Mutations in Hydin impair ciliary motility in mice. Lechtreck KF, et al. J Cell Biol, 2008 Feb 11. PMID 18250199, Free PMC Article
    2. Hydrocephalus-3, a Murine mutant. II. Changes in the brain extracellular space. McLone DG, et al. Surg Neurol, 1973 Jul. PMID 4732188
    3. Congenital hydrocephalus in hy3 mice is caused by a frameshift mutation in Hydin, a large novel gene. Davy BE, et al. Hum Mol Genet, 2003 May 15. PMID 12719380
    4. The pathophysiology and morphology of murine hydrocephalus in Hy-3 and Ch mutants. Raimondi AJ, et al. Surg Neurol, 1973 Jan. PMID 4784576
    5. Ependymal cilia beating induces an actin network to protect centrioles against shear stress. Mahuzier A, et al. Nat Commun, 2018 Jun 11. PMID 29891944, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. This paper describes a similar gene in mouse.
      Title: Congenital hydrocephalus in hy3 mice is caused by a frameshift mutation in Hydin, a large novel gene.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in axonemal central apparatus assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within axonemal central apparatus assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within brain development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cilium movement IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cilium movement ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within epithelial cell development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within trachea development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within ventricular system development ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in axonemal central apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in axonemal central pair projection ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in axoneme IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    hydrocephalus-inducing protein homolog
    Names
    hydrocephalus inducing

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427650.1 → NP_001414579.1  hydrocephalus-inducing protein homolog

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000019
      UniProtKB/TrEMBL
      A0A0G2JXD6

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      55146382..55492660
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039098232.2 → XP_038954160.1  hydrocephalus-inducing protein homolog isoform X1

      UniProtKB/TrEMBL
      A0A0G2JXD6, F1LSN6
      Related
      ENSRNOP00000023117.7, ENSRNOT00000023117.8
      Conserved Domains (6) summary
      PTZ00121
      Location:2311 → 2616
      PTZ00121; MAEBL; Provisional
      PRK00279
      Location:2249 → 2305
      adk; adenylate kinase; Reviewed
      pfam17380
      Location:2313 → 2460
      DUF5401; Family of unknown function (DUF5401)
      pfam15780
      Location:538 → 637
      ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin
      pfam17213
      Location:2051 → 2275
      Hydin_ADK; Hydin Adenylate kinase-like domain
      cl27657
      Location:227 → 302
      Motile_Sperm; MSP (Major sperm protein) domain

    2. XM_039098235.2 → XP_038954163.1  hydrocephalus-inducing protein homolog isoform X3

      UniProtKB/TrEMBL
      A0A0G2JXD6
      Conserved Domains (6) summary
      PTZ00121
      Location:2265 → 2570
      PTZ00121; MAEBL; Provisional
      PRK00279
      Location:2203 → 2259
      adk; adenylate kinase; Reviewed
      pfam17380
      Location:2267 → 2414
      DUF5401; Family of unknown function (DUF5401)
      pfam15780
      Location:538 → 637
      ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin
      pfam17213
      Location:2005 → 2229
      Hydin_ADK; Hydin Adenylate kinase-like domain
      cl27657
      Location:227 → 302
      Motile_Sperm; MSP (Major sperm protein) domain

    3. XM_039098234.2 → XP_038954162.1  hydrocephalus-inducing protein homolog isoform X2

      UniProtKB/TrEMBL
      A0A0G2JXD6
      Conserved Domains (6) summary
      PTZ00121
      Location:2304 → 2609
      PTZ00121; MAEBL; Provisional
      PRK00279
      Location:2242 → 2298
      adk; adenylate kinase; Reviewed
      pfam17380
      Location:2306 → 2453
      DUF5401; Family of unknown function (DUF5401)
      pfam15780
      Location:531 → 630
      ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin
      pfam17213
      Location:2044 → 2268
      Hydin_ADK; Hydin Adenylate kinase-like domain
      cl27657
      Location:227 → 302
      Motile_Sperm; MSP (Major sperm protein) domain

    4. XM_039098237.2 → XP_038954165.1  hydrocephalus-inducing protein homolog isoform X4

      UniProtKB/TrEMBL
      A0A0G2JXD6
      Conserved Domains (5) summary
      PRK00279
      Location:2249 → 2305
      adk; adenylate kinase; Reviewed
      pfam17380
      Location:2313 → 2460
      DUF5401; Family of unknown function (DUF5401)
      pfam15780
      Location:538 → 637
      ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin
      pfam17213
      Location:2051 → 2275
      Hydin_ADK; Hydin Adenylate kinase-like domain
      cl27657
      Location:227 → 302
      Motile_Sperm; MSP (Major sperm protein) domain

    5. XM_039098239.2 → XP_038954167.1  hydrocephalus-inducing protein homolog isoform X6

      Conserved Domains (5) summary
      PRK00279
      Location:2249 → 2305
      adk; adenylate kinase; Reviewed
      pfam17380
      Location:2313 → 2460
      DUF5401; Family of unknown function (DUF5401)
      pfam15780
      Location:538 → 637
      ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin
      pfam17213
      Location:2051 → 2275
      Hydin_ADK; Hydin Adenylate kinase-like domain
      cl27657
      Location:227 → 302
      Motile_Sperm; MSP (Major sperm protein) domain

    6. XM_063277933.1 → XP_063134003.1  hydrocephalus-inducing protein homolog isoform X9

    7. XM_063277934.1 → XP_063134004.1  hydrocephalus-inducing protein homolog isoform X10

    8. XM_063277935.1 → XP_063134005.1  hydrocephalus-inducing protein homolog isoform X11

    9. XM_039098238.2 → XP_038954166.1  hydrocephalus-inducing protein homolog isoform X5

      UniProtKB/TrEMBL
      A0A0G2JXD6
      Conserved Domains (3) summary
      PRK00279
      Location:1280 → 1336
      adk; adenylate kinase; Reviewed
      pfam17380
      Location:1344 → 1491
      DUF5401; Family of unknown function (DUF5401)
      pfam17213
      Location:1082 → 1306
      Hydin_ADK; Hydin Adenylate kinase-like domain

    10. XM_039098241.2 → XP_038954169.1  hydrocephalus-inducing protein homolog isoform X7

      Conserved Domains (4) summary
      PTZ00121
      Location:745 → 1050
      PTZ00121; MAEBL; Provisional
      PRK00279
      Location:683 → 739
      adk; adenylate kinase; Reviewed
      pfam17380
      Location:747 → 894
      DUF5401; Family of unknown function (DUF5401)
      pfam17213
      Location:485 → 709
      Hydin_ADK; Hydin Adenylate kinase-like domain

    11. XM_063277932.1 → XP_063134002.1  hydrocephalus-inducing protein homolog isoform X8

    Nucleotide Protein Strain
    Heading Accession and Version

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