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    Klhl28 kelch-like family member 28 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 299103, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Klhl28provided by RGD
    Official Full Name
    kelch-like family member 28provided by RGD
    Primary source
    RGD:1311326
    See related
    EnsemblRapid:ENSRNOG00000004218 AllianceGenome:RGD:1311326
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Btbd5
    Summary
    Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. Orthologous to human KLHL28 (kelch like family member 28). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 95.7), Muscle (RPKM 83.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Klhl28 in Genome Data Viewer
    Location:
    6q24
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (88723624..88755072, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (82987360..83018971, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (86680826..86713370, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 2D, pseudogene 2 Neighboring gene similar to human chromosome 14 open reading frame 28 Neighboring gene TOG array regulator of axonemal microtubules 1 Neighboring gene pre-mRNA processing factor 39 Neighboring gene small nucleolar RNA, C/D box 127

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ubiquitin-like ligase-substrate adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of Cul3-RING ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    kelch-like protein 28
    Names
    BTB (POZ) domain containing 5
    kelch-like 28

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106735.1 → NP_001100205.1  kelch-like protein 28

      See identical proteins and their annotated locations for NP_001100205.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473947
      UniProtKB/TrEMBL
      A6HBS6, D4AC05
      Related
      ENSRNOP00000005821.3, ENSRNOT00000005821.5
      Conserved Domains (2) summary
      PHA03098
      Location:35 → 553
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:423 → 465
      Kelch; KELCH repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      88723624..88755072 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006240135.4 → XP_006240197.1  kelch-like protein 28 isoform X1

      See identical proteins and their annotated locations for XP_006240197.1

      UniProtKB/TrEMBL
      A6HBS6, D4AC05
      Conserved Domains (2) summary
      PHA03098
      Location:35 → 553
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:423 → 465
      Kelch; KELCH repeat [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version

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