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    Adamts3 ADAM metallopeptidase with thrombospondin type 1, motif 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 305253, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Adamts3provided by RGD
    Official Full Name
    ADAM metallopeptidase with thrombospondin type 1, motif 3provided by RGD
    Primary source
    RGD:1310750
    See related
    EnsemblRapid:ENSRNOG00000027463 AllianceGenome:RGD:1310750
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable metalloendopeptidase activity. Predicted to be involved in several processes, including collagen biosynthetic process; positive regulation of vascular endothelial growth factor signaling pathway; and vascular endothelial growth factor production. Predicted to act upstream of or within in utero embryonic development and protein processing. Predicted to be located in extracellular space. Predicted to be active in extracellular matrix. Human ortholog(s) of this gene implicated in Hennekam syndrome. Orthologous to human ADAMTS3 (ADAM metallopeptidase with thrombospondin type 1 motif 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 61.2), Brain (RPKM 28.9) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Adamts3 in Genome Data Viewer
    Location:
    14p22
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (18515249..18721887)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (18231128..18437771)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (19866278..20072896)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134481731 Neighboring gene uncharacterized LOC134481730 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene neuropeptide FF receptor 2 Neighboring gene GC, vitamin D binding protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Procollagen II amino propeptide processing by ADAMTS-3. Insights on dermatosparaxis. Fernandes RJ, et al. J Biol Chem, 2001 Aug 24. PMID 11408482
    2. CCBE1 enhances lymphangiogenesis via A disintegrin and metalloprotease with thrombospondin motifs-3-mediated vascular endothelial growth factor-C activation. Jeltsch M, et al. Circulation, 2014 May 13. PMID 24552833
    3. Regulation of procollagen amino-propeptide processing during mouse embryogenesis by specialization of homologous ADAMTS proteases: insights on collagen biosynthesis and dermatosparaxis. Le Goff C, et al. Development, 2006 Apr. PMID 16556917
    4. Highly variable penetrance of abnormal phenotypes in embryonic lethal knockout mice. Wilson R, et al. Wellcome Open Res, 2016. PMID 27996060, Free PMC Article
    5. Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). Gonzalez-Begne M, et al. J Proteome Res, 2009 Mar. PMID 19199708, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in collagen biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in extracellular matrix organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within in utero embryonic development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of vascular endothelial growth factor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vascular endothelial growth factor production ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    A disintegrin and metalloproteinase with thrombospondin motifs 3
    Names
    a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 3
    NP_001381638.1
    NP_001381639.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001394709.1 → NP_001381638.1  A disintegrin and metalloproteinase with thrombospondin motifs 3 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/TrEMBL
      A0A8I5ZMX2
      Related
      ENSRNOP00000079355.1, ENSRNOT00000117104.2
      Conserved Domains (7) summary
      smart00209
      Location:554 → 605
      TSP1; Thrombospondin type 1 repeats
      cd04273
      Location:256 → 457
      ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
      pfam05986
      Location:713 → 828
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam01562
      Location:43 → 201
      Pep_M12B_propep; Reprolysin family propeptide
      pfam08686
      Location:1024 → 1052
      PLAC; PLAC (protease and lacunin) domain
      pfam17771
      Location:472 → 540
      ADAM_CR_2; ADAM cysteine-rich domain
      pfam19030
      Location:971 → 1016
      TSP1_ADAMTS; Thrombospondin type 1 domain

    2. NM_001394710.1 → NP_001381639.1  A disintegrin and metalloproteinase with thrombospondin motifs 3 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/TrEMBL
      A0A8I6AA07
      Related
      ENSRNOP00000088066.1, ENSRNOT00000115233.2
      Conserved Domains (7) summary
      smart00209
      Location:554 → 605
      TSP1; Thrombospondin type 1 repeats
      cd04273
      Location:256 → 457
      ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
      pfam05986
      Location:713 → 827
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam01562
      Location:43 → 201
      Pep_M12B_propep; Reprolysin family propeptide
      pfam08686
      Location:1023 → 1051
      PLAC; PLAC (protease and lacunin) domain
      pfam17771
      Location:472 → 540
      ADAM_CR_2; ADAM cysteine-rich domain
      pfam19030
      Location:970 → 1015
      TSP1_ADAMTS; Thrombospondin type 1 domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      18515249..18721887
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001107212.1: Suppressed sequence

      Description
      NM_001107212.1: This RefSeq was removed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    Nucleotide Protein Strain
    Heading Accession and Version

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