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    Ciapin1 cytokine induced apoptosis inhibitor 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 307649, updated on 27-Nov-2024

    Summary

    Official Symbol
    Ciapin1provided by RGD
    Official Full Name
    cytokine induced apoptosis inhibitor 1provided by RGD
    Primary source
    RGD:1549737
    See related
    EnsemblRapid:ENSRNOG00000016234 AllianceGenome:RGD:1549737
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable 2 iron, 2 sulfur cluster binding activity and iron ion binding activity. Predicted to be involved in iron-sulfur cluster assembly. Predicted to act upstream of or within hemopoiesis and negative regulation of apoptotic process. Predicted to be located in mitochondrion; nucleolus; and nucleoplasm. Predicted to be active in cytoplasm. Orthologous to human CIAPIN1 (cytokine induced apoptosis inhibitor 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Adrenal (RPKM 112.2), Heart (RPKM 108.2) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Ciapin1 in Genome Data Viewer
    Location:
    19p13
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (10185955..10199120)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (10179963..10195511)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (10596923..10612414)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene docking protein 4 Neighboring gene RNA polymerase II subunit C Neighboring gene coenzyme Q9 Neighboring gene C-C motif chemokine ligand 17 Neighboring gene aldo-keto reductase family 1 member B1-like

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    General gene information

    Markers

    Clone Names

    • MGC94686

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 2 iron, 2 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables 2 iron, 2 sulfur cluster binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables 2 iron, 2 sulfur cluster binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables 4 iron, 4 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables electron transfer activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables iron ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in hemopoiesis IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within hemopoiesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in iron-sulfur cluster assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in iron-sulfur cluster assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial intermembrane space IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    anamorsin
    Names
    fe-S cluster assembly protein DRE2 homolog

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001007689.1NP_001007690.1  anamorsin

      See identical proteins and their annotated locations for NP_001007690.1

      Status: PROVISIONAL

      Source sequence(s)
      BC083753
      UniProtKB/Swiss-Prot
      Q5XID1
      UniProtKB/TrEMBL
      A0A8I6ASY3, A6JY45
      Related
      ENSRNOP00000021769.3, ENSRNOT00000021769.7
      Conserved Domains (2) summary
      cd02440
      Location:2196
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
      pfam05093
      Location:233301
      CIAPIN1; Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      10185955..10199120
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006255107.5XP_006255169.1  anamorsin isoform X1

      See identical proteins and their annotated locations for XP_006255169.1

      UniProtKB/Swiss-Prot
      Q5XID1
      UniProtKB/TrEMBL
      A0A8I6ASY3, A6JY45
      Conserved Domains (2) summary
      cd02440
      Location:2196
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
      pfam05093
      Location:233301
      CIAPIN1; Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis
    2. XM_006255108.5XP_006255170.1  anamorsin isoform X1

      See identical proteins and their annotated locations for XP_006255170.1

      UniProtKB/Swiss-Prot
      Q5XID1
      UniProtKB/TrEMBL
      A0A8I6ASY3, A6JY45
      Related
      ENSRNOP00000106580.1, ENSRNOT00000172702.1
      Conserved Domains (2) summary
      cd02440
      Location:2196
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
      pfam05093
      Location:233301
      CIAPIN1; Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis
    3. XM_006255106.5XP_006255168.1  anamorsin isoform X1

      See identical proteins and their annotated locations for XP_006255168.1

      UniProtKB/Swiss-Prot
      Q5XID1
      UniProtKB/TrEMBL
      A0A8I6ASY3, A6JY45
      Conserved Domains (2) summary
      cd02440
      Location:2196
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
      pfam05093
      Location:233301
      CIAPIN1; Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis
    4. XM_063277990.1XP_063134060.1  anamorsin isoform X1

      UniProtKB/Swiss-Prot
      Q5XID1
      UniProtKB/TrEMBL
      A6JY45
      Related
      ENSRNOP00000096214.1, ENSRNOT00000116645.2
    5. XM_039097710.2XP_038953638.1  anamorsin isoform X1

      UniProtKB/Swiss-Prot
      Q5XID1
      UniProtKB/TrEMBL
      A0A8I6ASY3, A6JY45
      Conserved Domains (2) summary
      cd02440
      Location:2196
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
      pfam05093
      Location:233301
      CIAPIN1; Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis